Genular: Defining Cellular Identity and Function

Details for: Lrp6

Gene ID: 16974

Symbol: Lrp6

Ensembl ID: ENSMUSG00000030201

Description: low density lipoprotein receptor-related protein 6

Associated with

Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
Negative regulation of tcf-dependent signaling by wnt ligand antagonists
(R-MMU-3772470)
Regulation of fzd by ubiquitination
(R-MMU-4641263)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Anterior/posterior pattern specification
(GO:0009952)
Apolipoprotein binding
(GO:0034185)
Axis elongation
(GO:0003401)
Bone remodeling
(GO:0046849)
Canonical wnt signaling pathway
(GO:0060070)
Cardiac muscle tissue morphogenesis
(GO:0055008)
Cell migration involved in gastrulation
(GO:0042074)
Cerebellum morphogenesis
(GO:0021587)
Cerebral cortex cell migration
(GO:0021795)
Cerebral cortex development
(GO:0021987)
Chemical synaptic transmission
(GO:0007268)
Convergent extension
(GO:0060026)
Coreceptor activity
(GO:0015026)
Dorsal/ventral axis specification
(GO:0009950)
Embryonic camera-type eye morphogenesis
(GO:0048596)
Embryonic digit morphogenesis
(GO:0042733)
Embryonic forelimb morphogenesis
(GO:0035115)
Embryonic hindlimb morphogenesis
(GO:0035116)
Embryonic limb morphogenesis
(GO:0030326)
Embryonic pattern specification
(GO:0009880)
Embryonic retina morphogenesis in camera-type eye
(GO:0060059)
Endocytosis
(GO:0006897)
External genitalia morphogenesis
(GO:0035261)
Fat cell differentiation
(GO:0045444)
Forebrain development
(GO:0030900)
Forebrain generation of neurons
(GO:0021872)
Forebrain radial glial cell differentiation
(GO:0021861)
Formation of radial glial scaffolds
(GO:0021943)
Frizzled binding
(GO:0005109)
Gastrulation with mouth forming second
(GO:0001702)
Generation of neurons
(GO:0048699)
Heart looping
(GO:0001947)
Identical protein binding
(GO:0042802)
Kinase inhibitor activity
(GO:0019210)
Limb morphogenesis
(GO:0035108)
Low-density lipoprotein particle receptor activity
(GO:0005041)
Mesenchymal cell proliferation
(GO:0010463)
Mesodermal cell migration
(GO:0008078)
Midbrain-hindbrain boundary development
(GO:0030917)
Midbrain development
(GO:0030901)
Morphogenesis of an epithelium
(GO:0002009)
Multicellular organism development
(GO:0007275)
Negative regulation of developmental process
(GO:0051093)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of smooth muscle cell apoptotic process
(GO:0034392)
Neural crest cell differentiation
(GO:0014033)
Neural crest formation
(GO:0014029)
Neural tube closure
(GO:0001843)
Neural tube development
(GO:0021915)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Outflow tract morphogenesis
(GO:0003151)
Pericardium morphogenesis
(GO:0003344)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of bone resorption
(GO:0045780)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of ossification
(GO:0045778)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Post-anal tail morphogenesis
(GO:0036342)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of anatomical structure morphogenesis
(GO:0022603)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of epithelial cell proliferation
(GO:0050678)
Response to folic acid
(GO:0051593)
Retina morphogenesis in camera-type eye
(GO:0060042)
Roof of mouth development
(GO:0060021)
Signaling receptor binding
(GO:0005102)
Skeletal system morphogenesis
(GO:0048705)
Somitogenesis
(GO:0001756)
Thalamus development
(GO:0021794)
Toxin transmembrane transporter activity
(GO:0019534)
Wnt-protein binding
(GO:0017147)
Wnt receptor activity
(GO:0042813)
Wnt signaling pathway
(GO:0016055)
Wnt signaling pathway involved in forebrain neuroblast division
(GO:0021874)

Other Information

Proteins

Low-density lipoprotein receptor-related protein 6
A0A0R4J0A9_MOUSE

Genular Protein ID: 1677911194

Symbol: LRP6_MOUSE

Name: Low-density lipoprotein receptor-related protein 6

UniProtKB Accession Codes:

O88572

Database IDs:

Citations:

PubMed ID: 9704021

Title: Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.

PubMed ID: 9704021

DOI: 10.1006/bbrc.1998.9061

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12581525

Title: Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.

PubMed ID: 12581525

DOI: 10.1016/s0092-8674(03)00045-x

PubMed ID: 12573468

Title: Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons.

PubMed ID: 12573468

DOI: 10.1016/s0168-0102(02)00226-2

PubMed ID: 15142971

Title: The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.

PubMed ID: 15142971

DOI: 10.1242/dev.01137

PubMed ID: 16543246

Title: Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.

PubMed ID: 16543246

DOI: 10.1074/jbc.m508324200

PubMed ID: 17376403

Title: GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway.

PubMed ID: 17376403

DOI: 10.1016/j.bbrc.2007.03.019

PubMed ID: 17698587

Title: Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor.

PubMed ID: 17698587

DOI: 10.1128/mcb.00773-07

PubMed ID: 19857465

Title: Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling.

PubMed ID: 19857465

DOI: 10.1016/j.bbrc.2009.10.113

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 15469977

Title: Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis.

PubMed ID: 15469977

DOI: 10.1242/dev.01405

PubMed ID: 18505367

Title: Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd.

PubMed ID: 18505367

DOI: 10.1359/jbmr.080512

Sequence Information:

Length: 1613
Mass: 180255
Checksum: 3C2ABC8EEEB17622
Sequence:

MGAVLRSLLA CSFCVLLRAA PLLLYANRRD LRLVDATNGK ENATIVVGGL EDAAAVDFVF 
GHGLIYWSDV SEEAIKRTEF NKSESVQNVV VSGLLSPDGL ACDWLGEKLY WTDSETNRIE 
VSNLDGSLRK VLFWQELDQP RAIALDPSSG FMYWTDWGEV PKIERAGMDG SSRFVIINTE 
IYWPNGLTLD YQERKLYWAD AKLNFIHKSN LDGTNRQAVV KGSLPHPFAL TLFEDTLYWT 
DWNTHSILAC NKYTGEGLRE IHSNIFSPMD IHAFSQQRQP NATNPCGIDN GGCSHLCLMS 
PVKPFYQCAC PTGVKLMENG KTCKDGATEL LLLARRTDLR RISLDTPDFT DIVLQLEDIR 
HAIAIDYDPV EGYIYWTDDE VRAIRRSFID GSGSQFVVTA QIAHPDGIAV DWVARNLYWT 
DTGTDRIEVT RLNGTMRKIL ISEDLEEPRA IVLDPMVGYM YWTDWGEIPK IERAALDGSD 
RVVLVNTSLG WPNGLALDYD EGTIYWGDAK TDKIEVMNTD GTGRRVLVED KIPHIFGFTL 
LGDYVYWTDW QRRSIERVHK RSAEREVIID QLPDLMGLKA TSVHRVIGSN PCAEDNGGCS 
HLCLYRPQGL RCACPIGFEL IGDMKTCIVP EAFLLFSRRA DIRRISLETN NNNVAIPLTG 
VKEASALDFD VTDNRIYWTD ISLKTISRAF MNGSALEHVV EFGLDYPEGM AVDWLGKNLY 
WADTGTNRIE VSKLDGQHRQ VLVWKDLDSP RALALDPAEG FMYWTEWGGK PKIDRAAMDG 
SERTTLVPNV GRANGLTIDY AKRRLYWTDL DTNLIESSDM LGLNREVIAD DLPHPFGLTQ 
YQDYIYWTDW SRRSIERANK TSGQNRTIIQ GHLDYVMDIL VFHSSRQAGW NECASSNGHC 
SHLCLAVPVG GFVCGCPAHY SLNADNRTCS APSTFLLFSQ KSAINRMVID EQQSPDIILP 
IHSLRNVRAI DYDPLDKQLY WIDSRQNSIR KAHEDGGQGF NVVANSVANQ NLEIQPYDLS 
IDIYSRYIYW TCEATNVIDV TRLDGRSVGV VLKGEQDRPR AIVVNPEKGY MYFTNLQERS 
PKIERAALDG TEREVLFFSG LSKPIALALD SKLGKLFWAD SDLRRIESSD LSGANRIVLE 
DSNILQPVGL TVFENWLYWI DKQQQMIEKI DMTGREGRTK VQARIAQLSD IHAVKELNLQ 
EYRQHPCAQD NGGCSHICLV KGDGTTRCSC PMHLVLLQDE LSCGEPPTCS PQQFTCFTGD 
IDCIPVAWRC DGFTECEDHS DELNCPVCSE SQFQCASGQC IDGALRCNGD ANCQDKSDEK 
NCEVLCLIDQ FRCANGQCVG KHKKCDHSVD CSDRSDELDC YPTEEPAPQA TNTVGSVIGV 
IVTIFVSGTI YFICQRMLCP RMKGDGETMT NDYVVHSPAS VPLGYVPHPS SLSGSLPGMS 
RGKSMISSLS IMGGSSGPPY DRAHVTGASS SSSSSTKGTY FPAILNPPPS PATERSHYTM 
EFGYSSNSPS THRSYSYRPY SYRHFAPPTT PCSTDVCDSD YAPSRRMTSV ATAKGYTSDV 
NYDSEPVPPP PTPRSQYLSA EENYESCPPS PYTERSYSHH LYPPPPSPCT DSS

Genular Protein ID: 2243619382

Symbol: A0A0R4J0A9_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J0A9

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1613
Mass: 180309
Checksum: 0E7EA6B84421F481
Sequence:

MGAVLRSLLA CSFCVLLRAA PLLLYANRRD LRLVDATNGK ENATIVVGGL EDAAAVDFVF 
GHGLIYWSDV SEEAIKRTEF NKTESVQNVV VSGLLSPDGL ACDWLGEKLY WTDSETNRIE 
VSNLDGSLRK VLFWQELDQP RAIALDPSSG FMYWTDWGEV PKIERAGMDG SSRFVIINTE 
IYWPNGLTLD YQERKLYWAD AKLNFIHKSN LDGTNRQAVV KGSLPHPFAL TLFEDTLYWT 
DWNTHSILAC NKYTGEGLRE IHSNIFSPMD IHAFSQQRQP NATNPCGIDN GGCSHLCLMS 
PVKPFYQCAC PTGVKLLENG KTCKDGATEL LLLARRTDLR RISLDTPDFT DIVLQLEDIR 
HAIAIDYDPV EGYIYWTDDE VRAIRRSFID GSGSQFVVTA QIAHPDGIAV DWVARNLYWT 
DTGTDRIEVT RLNGTMRKIL ISEDLEEPRA IVLDPMVGYM YWTDWGEIPK IERAALDGSD 
RVVLVNTSLG WPNGLALDYD EGTIYWGDAK TDKIEVMNTD GTGRRVLVED KIPHIFGFTL 
LGDYVYWTDW QRRSIERVHK RSAEREVIID QLPDLMGLKA TSVHRIIGSN PCAEDNGGCS 
HLCLYRPQGL RCACPIGFEL ISDMKTCIVP EAFLLFSRRA DIRRISLETN NNNVAIPLTG 
VKEASALDFD VTDNRIYWTD ISLKTISRAF MNGSALEHVV EFGLDYPEGM AVDWLGKNLY 
WADTGTNRIE VSKLDGQHRQ VLVWKDLDSP RALALDPAEG FMYWTEWGGK PKIDRAAMDG 
SERTTLVPNV GRANGLTIDY AKRRLYWTDL DTNLIESSDM LGLNREVIAD DLPHPFGLTQ 
YQDYIYWTDW SRRSIERANK TSGQNRTIIQ GHLDYVMDIL VFHSSRQAGW NECASSNGHC 
SHLCLAVPVG GFVCGCPAHY SLNADNRTCS APTTFLLFSQ KSAINRMVID EQQSPDIILP 
IHSLRNVRAI DYDPLDKQLY WIDSRQNSIR KAHEDGGQGF NVVANSVANQ NLEIQPYDLS 
IDIYSRYIYW TCEATNVIDV TRLDGRSVGV VLKGEQDRPR AIVVNPEKGY MYFTNLQERS 
PKIERAALDG TEREVLFFSG LSKPIALALD SKLGKLFWAD SDLRRIESSD LSGANRIVLE 
DSNILQPVGL TVFENWLYWI DKQQQMIEKI DMTGREGRTK VQARIAQLSD IHAVKELNLQ 
EYRQHPCAQD NGGCSHICLV KGDGTTRCSC PMHLVLLQDE LSCGEPPTCS PQQFTCFTGD 
IDCIPVAWRC DGFTECEDHS DELNCPVCSE SQFQCASGQC IDGALRCNGD ANCQDKSDEK 
NCEVLCLIDQ FRCANGQCVG KHKKCDHSVD CSDRSDELDC YPTEEPAPQA TNTVGSVIGV 
IVTIFVSGTI YFICQRMLCP RMKGDGETMT NDYVVHSPAS VPLGYVPHPS SLSGSLPGMS 
RGKSMISSLS IMGGSSGPPY DRAHVTGASS SSSSSTKGTY FPAILNPPPS PATERSHYTM 
EFGYSSNSPS THRSYSYRPY SYRHFAPPTT PCSTDVCDSD YAPSRRMTSV ATAKGYTSDV 
NYDSEPVPPP PTPRSQYLSA EENYESCPPS PYTERSYSHH LYPPPPSPCT DSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lrp6

Associated with

Other Information

Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family. PubMed ID: 9704021

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. PubMed ID: 12581525

Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons. PubMed ID: 12573468

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. PubMed ID: 15142971

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. PubMed ID: 16543246

GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway. PubMed ID: 17376403

Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor. PubMed ID: 17698587

Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling. PubMed ID: 19857465

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. PubMed ID: 31073040

Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. PubMed ID: 15469977

Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd. PubMed ID: 18505367

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 9704021

PubMed ID: 15489334

PubMed ID: 12581525

PubMed ID: 12573468

PubMed ID: 15142971

PubMed ID: 16543246

PubMed ID: 17376403

PubMed ID: 17698587

PubMed ID: 19857465

PubMed ID: 21183079

PubMed ID: 31073040

PubMed ID: 15469977

PubMed ID: 18505367

PubMed ID: 19468303

PubMed ID: 21183079