Genular: Defining Cellular Identity and Function

Details for: Lta

Gene ID: 16992

Symbol: Lta

Ensembl ID: ENSMUSG00000024402

Description: lymphotoxin A

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-MMU-5676594)
Tnfs bind their physiological receptors
(R-MMU-5669034)
Cytokine activity
(GO:0005125)
Defense response to gram-positive bacterium
(GO:0050830)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Humoral immune response
(GO:0006959)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Lymph node development
(GO:0048535)
Membrane
(GO:0016020)
Negative regulation of fibroblast proliferation
(GO:0048147)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of chronic inflammatory response to antigenic stimulus
(GO:0002876)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of humoral immune response mediated by circulating immunoglobulin
(GO:0002925)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Tumor necrosis factor receptor binding
(GO:0005164)
Type ii interferon production
(GO:0032609)

Other Information

Proteins

Lymphotoxin-alpha

Genular Protein ID: 3513156394

Symbol: TNFB_MOUSE

Name: Lymphotoxin-alpha

UniProtKB Accession Codes:

P09225

Database IDs:

Citations:

PubMed ID: 3684584

Title: Nucleotide sequence of the murine TNF locus, including the TNF-alpha (tumor necrosis factor) and TNF-beta (lymphotoxin) genes.

PubMed ID: 3684584

DOI: 10.1093/nar/15.21.9083

PubMed ID: 3490653

Title: The genes for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) are tandemly arranged on chromosome 17 of the mouse.

PubMed ID: 3490653

DOI: 10.1093/nar/14.19.7713

PubMed ID: 3588316

Title: The murine tumor necrosis factor-beta (lymphotoxin) gene sequence.

PubMed ID: 3588316

DOI: 10.1093/nar/15.9.3937

PubMed ID: 2884262

Title: Cloning and expression of murine lymphotoxin cDNA.

PubMed ID: 2884262

PubMed ID: 2885372

Title: Mouse lymphotoxin and tumor necrosis factor: structural analysis of the cloned genes, physical linkage, and chromosomal position.

PubMed ID: 2885372

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 3147435

Title: Induction of tumor necrosis factor-alpha and -beta and interferon-gamma mRNA by interleukin 2 in murine lymphocytic cell lines.

PubMed ID: 3147435

PubMed ID: 1700275

Title: RNA processing is a limiting step for murine tumor necrosis factor beta expression in response to interleukin-2.

PubMed ID: 1700275

DOI: 10.1128/mcb.10.11.5865-5875.1990

Sequence Information:

Length: 202
Mass: 21999
Checksum: F496F83C685950D3
Sequence:

MTLLGRLHLL RVLGTPPVFL LGLLLALPLG AQGLSGVRFS AARTAHPLPQ KHLTHGILKP 
AAHLVGYPSK QNSLLWRAST DRAFLRHGFS LSNNSLLIPT SGLYFVYSQV VFSGESCSPR 
AIPTPIYLAH EVQLFSSQYP FHVPLLSAQK SVYPGLQGPW VRSMYQGAVF LLSKGDQLST 
HTDGISHLHF SPSSVFFGAF AL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lta

Associated with

Other Information

Nucleotide sequence of the murine TNF locus, including the TNF-alpha (tumor necrosis factor) and TNF-beta (lymphotoxin) genes. PubMed ID: 3684584

The genes for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) are tandemly arranged on chromosome 17 of the mouse. PubMed ID: 3490653

The murine tumor necrosis factor-beta (lymphotoxin) gene sequence. PubMed ID: 3588316

Cloning and expression of murine lymphotoxin cDNA. PubMed ID: 2884262

Mouse lymphotoxin and tumor necrosis factor: structural analysis of the cloned genes, physical linkage, and chromosomal position. PubMed ID: 2885372

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. PubMed ID: 14656967

Induction of tumor necrosis factor-alpha and -beta and interferon-gamma mRNA by interleukin 2 in murine lymphocytic cell lines. PubMed ID: 3147435

RNA processing is a limiting step for murine tumor necrosis factor beta expression in response to interleukin-2. PubMed ID: 1700275