Genular: Defining Cellular Identity and Function

Details for: Lta4h

Gene ID: 16993

Symbol: Lta4h

Ensembl ID: ENSMUSG00000015889

Description: leukotriene A4 hydrolase

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Biosynthesis of aspirin-triggered d-series resolvins
(R-MMU-9020265)
Biosynthesis of d-series resolvins
(R-MMU-9018676)
Biosynthesis of dha-derived spms
(R-MMU-9018677)
Biosynthesis of e-series 18(r)-resolvins
(R-MMU-9023661)
Biosynthesis of e-series 18(s)-resolvins
(R-MMU-9018896)
Biosynthesis of epa-derived spms
(R-MMU-9018679)
Biosynthesis of protectins
(R-MMU-9018681)
Biosynthesis of specialized proresolving mediators (spms)
(R-MMU-9018678)
Fatty acid metabolism
(R-MMU-8978868)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Neutrophil degranulation
(R-MMU-6798695)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-MMU-2142691)
Aminopeptidase activity
(GO:0004177)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Epoxide hydrolase activity
(GO:0004301)
Hydrolase activity
(GO:0016787)
Leukotriene-a4 hydrolase activity
(GO:0004463)
Leukotriene biosynthetic process
(GO:0019370)
Leukotriene metabolic process
(GO:0006691)
Metal ion binding
(GO:0046872)
Metalloaminopeptidase activity
(GO:0070006)
Metallopeptidase activity
(GO:0008237)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Peptide catabolic process
(GO:0043171)
Protein binding
(GO:0005515)
Protein metabolic process
(GO:0019538)
Proteolysis
(GO:0006508)
Tripeptide aminopeptidase activity
(GO:0045148)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Leukotriene A-4 hydrolase

Genular Protein ID: 2353744721

Symbol: LKHA4_MOUSE

Name: Leukotriene A-4 hydrolase

UniProtKB Accession Codes:

P24527 Q3UY71 Q8VDR8

Database IDs:

Citations:

PubMed ID: 1710117

Title: Molecular cloning and expression of mouse leukotriene A4 hydrolase cDNA.

PubMed ID: 1710117

DOI: 10.1016/0006-291x(91)90459-k

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1881903

Title: Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis.

PubMed ID: 1881903

DOI: 10.1073/pnas.88.17.7620

PubMed ID: 9287304

Title: Mutation of tyrosine 383 in leukotriene A4 hydrolase allows conversion of leukotriene A4 into 5S,6S-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid. Implications for the epoxide hydrolase mechanism.

PubMed ID: 9287304

DOI: 10.1074/jbc.272.37.23057

PubMed ID: 10586081

Title: Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice.

PubMed ID: 10586081

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20813919

Title: A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.

PubMed ID: 20813919

DOI: 10.1126/science.1190594

Sequence Information:

Length: 611
Mass: 69051
Checksum: CCF8D30F6FA9721E
Sequence:

MPEVADTCSL ASPASVCRTQ HLHLRCSVDF ARRTLTGTAA LTVQSQEENL RSLTLDTKDL 
TIEKVVINGQ EVKYTLGESQ GYKGSPMEIS LPIALSKNQE IVIEISFETS PKSSALQWLT 
PEQTSGKQHP YLFSQCQAIH CRAILPCQDT PSVKLTYTAE VSVPKELVAL MSAIRDGEAP 
DPEDPSRKIY RFNQRVPIPC YLIALVVGAL ESRQIGPRTL VWSEKEQVEK SANEFSETES 
MLKIAEDLGG PYVWGQYDLL VLPPSFPYGG MENPCLTFVT PTLLAGDKSL SNVIAHEISH 
SWTGNLVTNK TWDHFWLNEG HTVYLERHIC GRLFGEKFRH FHALGGWGEL QNTIKTFGES 
HPFTKLVVDL KDVDPDVAYS SIPYEKGFAL LFYLEQLLGG PEVFLGFLKA YVKKFSYQSV 
TTDDWKSFLY SHFKDKVDLL NQVDWNTWLY APGLPPVKPN YDVTLTNACI ALSQRWVTAK 
EEDLSSFSIA DLKDLSSHQL NEFLAQVLQK APLPLGHIKR MQEVYNFNAI NNSEIRFRWL 
RLCIQSKWEE AIPLALKMAT EQGRMKFTRP LFKDLAAFDK SHDQAVHTYQ EHKASMHPVT 
AMLVGRDLKV D

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lta4h

Associated with

Other Information

Molecular cloning and expression of mouse leukotriene A4 hydrolase cDNA. PubMed ID: 1710117

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis. PubMed ID: 1881903

Mutation of tyrosine 383 in leukotriene A4 hydrolase allows conversion of leukotriene A4 into 5S,6S-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid. Implications for the epoxide hydrolase mechanism. PubMed ID: 9287304

Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. PubMed ID: 10586081

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation. PubMed ID: 20813919