Genular: Defining Cellular Identity and Function

Details for: Ltbp3

Gene ID: 16998

Symbol: Ltbp3

Ensembl ID: ENSMUSG00000024940

Description: latent transforming growth factor beta binding protein 3

Associated with

Elastic fibre formation
(R-MMU-1566948)
Extracellular matrix organization
(R-MMU-1474244)
Molecules associated with elastic fibres
(R-MMU-2129379)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Tgf-beta receptor signaling activates smads
(R-MMU-2173789)
Bone mineralization
(GO:0030282)
Bone morphogenesis
(GO:0060349)
Bone remodeling
(GO:0046849)
Calcium ion binding
(GO:0005509)
Chondrocyte differentiation
(GO:0002062)
Collagen-containing extracellular matrix
(GO:0062023)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Growth factor binding
(GO:0019838)
Lung saccule development
(GO:0060430)
Negative regulation of bone mineralization
(GO:0030502)
Negative regulation of chondrocyte differentiation
(GO:0032331)
Positive regulation of bone resorption
(GO:0045780)
Positive regulation of mesenchymal stem cell differentiation
(GO:2000741)
Positive regulation of mesenchymal stem cell proliferation
(GO:1902462)
Skeletal system development
(GO:0001501)
Transforming growth factor beta activation
(GO:0036363)
Transforming growth factor beta binding
(GO:0050431)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)

Other Information

Proteins

Latent-transforming growth factor beta-binding protein 3

Genular Protein ID: 1749293337

Symbol: LTBP3_MOUSE

Name: Latent-transforming growth factor beta-binding protein 3

UniProtKB Accession Codes:

Q61810 F8VQ06 Q8BNQ6

Database IDs:

Citations:

PubMed ID: 7730318

Title: Isolation of a novel latent transforming growth factor-beta binding protein gene (LTBP-3).

PubMed ID: 7730318

DOI: 10.1074/jbc.270.17.10147

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 9602168

Title: 8-cysteine TGF-BP structural motifs are the site of covalent binding between mouse LTBP-3, LTBP-2, and latent TGF-beta 1.

PubMed ID: 9602168

DOI: 10.1016/s0167-4838(98)00003-x

PubMed ID: 12062452

Title: Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion.

PubMed ID: 12062452

DOI: 10.1016/s0014-5793(02)02648-0

PubMed ID: 10743502

Title: Latent transforming growth factor-beta binding proteins (LTBPs) -- structural extracellular matrix proteins for targeting TGF-beta action.

PubMed ID: 10743502

DOI: 10.1016/s1359-6101(99)00010-6

PubMed ID: 11104663

Title: The latent transforming growth factor beta binding protein (LTBP) family.

PubMed ID: 11104663

DOI: 10.1042/bj3520601

Sequence Information:

Length: 1253
Mass: 134363
Checksum: C773F38FD65F186E
Sequence:

MPGPRGAAHG LAPAMRQAGA LGLLALLLLA LLGPGGGAEG GPAGERGTGG GGALARERFK 
VVFAPVICKR TCLKGQCRDS CQQGSNMTLI GENGHSTDTL TGSGFRVVVC PLPCMNGGQC 
SSRNQCLCPP DFTGRFCQVP AAGTGAGTGS SGPGLARTGA MSTGPLPPLA PEGESVASKH 
AIYAVQVIAD PPGPGEGPPA QHAAFLVPLG PGQISAEVQA PPPVVNVRVH HPPEASVQVH 
RIEGPNAEGP ASSQHLLPHP KPQHPRPPTQ KPLGRCFQDT LPKQPCGSNP LPGLTKQEDC 
CGSIGTAWGQ SKCHKCPQLQ YTGVQKPGPV RGEVGADCPQ GYKRLNSTHC QDINECAMPG 
MCRHGDCLNN PGSYRCVCPP GHSLGPSRTQ CIADKPEEKS LCFRLVSTEH QCQHPLTTRL 
TRQLCCCSVG KAWGARCQRC PADGTAAFKE ICPAGKGYHI LTSHQTLTIQ GESDFSLFLH 
PDGPPKPQQL PESPSRAPPL EDTEEERGVT MDPPVSEERS VQQSHPTTTT SPPRPYPELI 
SRPSPPTFHR FLPDLPPSRS AVEIAPTQVT ETDECRLNQN ICGHGQCVPG PSDYSCHCNA 
GYRSHPQHRY CVDVNECEAE PCGPGKGICM NTGGSYNCHC NRGYRLHVGA GGRSCVDLNE 
CTKPHLCGDG GFCINFPGHY KCNCYPGYRL KASRPPICED IDECRDPSTC PDGKCENKPG 
SFKCIACQPG YRSQGGGACR DVNECSEGTP CSPGWCENLP GSYRCTCAQG YEPAQDGLSC 
IDVDECEAGK VCQDGICTNT PGSFQCQCLS GYHLSRDRSR CEDIDECDFP AACIGGDCIN 
TNGSYRCLCP QGHRLVGGRK CQDIDECSQD PGLCLPHGAC ENLQGSYVCV CDEGFTLTQD 
QHGCEEVEQP HHKKECYLNF DDTVFCDSVL ATNVTQQECC CSLGAGWGDH CEIYPCPVYS 
SAEFHSLCPD GKGYTQDNNI VNYGIPAHRD IDECILFGAE ICKEGKCVNT QPGYECYCKQ 
GFYYDGNLLE CVDVDECLDE SNCRNGVCEN TRGGYRCACT PPAEYSPAQR QCLSPEEMEH 
APERREVCWG QRGEDGMCMG PLAGPALTFD DCCCRQGRGW GTQCRPCPPR GTGSQCPTSQ 
SESNSFWDTS PLLLGKSPRD EDSSEEDSDE CRCVSGRCVP RPGGAVCECP GGFQLDASRA 
RCVDIDECRE LNQRGLLCKS ERCVNTSGSF RCVCKAGFTR SRPHGACVPQ RRR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ltbp3

Associated with

Other Information

Isolation of a novel latent transforming growth factor-beta binding protein gene (LTBP-3). PubMed ID: 7730318

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

8-cysteine TGF-BP structural motifs are the site of covalent binding between mouse LTBP-3, LTBP-2, and latent TGF-beta 1. PubMed ID: 9602168

Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. PubMed ID: 12062452

Latent transforming growth factor-beta binding proteins (LTBPs) -- structural extracellular matrix proteins for targeting TGF-beta action. PubMed ID: 10743502

The latent transforming growth factor beta binding protein (LTBP) family. PubMed ID: 11104663