Genular: Defining Cellular Identity and Function

Details for: Blnk

Gene ID: 17060

Symbol: Blnk

Ensembl ID: ENSMUSG00000061132

Description: B cell linker

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-MMU-983695)
Immune system
(R-MMU-168256)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
B cell activation
(GO:0042113)
B cell receptor signaling pathway
(GO:0050853)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular signal transduction
(GO:0035556)
Lipid binding
(GO:0008289)
Membrane
(GO:0016020)
Phospholipase binding
(GO:0043274)
Plasma membrane
(GO:0005886)
Positive regulation of gene expression
(GO:0010628)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein tyrosine kinase binding
(GO:1990782)
Sh2 domain binding
(GO:0042169)
Signaling adaptor activity
(GO:0035591)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

B-cell linker protein

Genular Protein ID: 1500924877

Symbol: BLNK_MOUSE

Name: B-cell linker protein

UniProtKB Accession Codes:

Q9QUN3 O88504

Database IDs:

Citations:

PubMed ID: 9697839

Title: BLNK: a central linker protein in B cell activation.

PubMed ID: 9697839

DOI: 10.1016/s1074-7613(00)80591-9

PubMed ID: 9705962

Title: SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation.

PubMed ID: 9705962

DOI: 10.1084/jem.188.4.791

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11449366

Title: Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha.

PubMed ID: 11449366

DOI: 10.1002/1521-4141(200107)31:7<2126::aid-immu2126>3.0.co;2-o

PubMed ID: 11859098

Title: Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Igalpha.

PubMed ID: 11859098

DOI: 10.4049/jimmunol.168.5.2127

PubMed ID: 11909947

Title: The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.

PubMed ID: 11909947

DOI: 10.1128/mcb.22.8.2524-2535.2002

PubMed ID: 12761551

Title: Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia.

PubMed ID: 12761551

DOI: 10.1038/nature01608

PubMed ID: 18369315

Title: The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.

PubMed ID: 18369315

DOI: 10.1038/emboj.2008.62

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

PubMed ID: 28290451

Title: Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP.

PubMed ID: 28290451

DOI: 10.1038/icb.2017.10

Sequence Information:

Length: 457
Mass: 50671
Checksum: 66C93D4FDDF9D260
Sequence:

MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMDKIKKLK VKGPPSVPRR DYALDSPADE 
EEQWSDDFDS DYENPDEHSD SEMYVMPAEE TGDDSYEPPP AEQQTRVVHP ALPFTRGEYV 
DNRSSQRHSP PFSKTLPSKP SWPSAKARLA STLPAPNSLQ KPQVPPKPKD LLEDEADYVV 
PVEDNDENYI HPRESSPPPA EKAPMVNRST KPNSSSKHMS PPGTVAGRNS GVWDSKSSLP 
AAPSPLPRAG KKPATPLKTT PVPPLPNASN VCEEKPVPAE RHRGSSHRQD TVQSPVFPPT 
QKPVHQKPVP LPRFPEAGSP AADGPFHSFP FNSTFADQEA ELLGKPWYAG ACDRKSAEEA 
LHRSNKDGSF LIRKSSGHDS KQPYTLVAFF NKRVYNIPVR FIEATKQYAL GKKKNGEEYF 
GSVVEIVNSH QHNPLVLIDS QNNTKDSTRL KYAVKVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Blnk

Associated with

Other Information

BLNK: a central linker protein in B cell activation. PubMed ID: 9697839

SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation. PubMed ID: 9705962

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha. PubMed ID: 11449366

Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Igalpha. PubMed ID: 11859098

The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. PubMed ID: 11909947

Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia. PubMed ID: 12761551

The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. PubMed ID: 18369315

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling. PubMed ID: 21930792

Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP. PubMed ID: 28290451