Genular: Defining Cellular Identity and Function

Details for: Il1rl1

Gene ID: 17082

Symbol: Il1rl1

Ensembl ID: ENSMUSG00000026069

Description: interleukin 1 receptor-like 1

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-33 signaling
(R-MMU-9014843)
Intracellular signaling by second messengers
(R-MMU-9006925)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Signaling by interleukins
(R-MMU-449147)
Cell surface
(GO:0009986)
Cytosol
(GO:0005829)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Focal adhesion
(GO:0005925)
Hydrolase activity
(GO:0016787)
Inflammatory response
(GO:0006954)
Interleukin-1 receptor activity
(GO:0004908)
Interleukin-33 binding
(GO:0002113)
Interleukin-33 receptor activity
(GO:0002114)
Interleukin-33-mediated signaling pathway
(GO:0038172)
Macrophage differentiation
(GO:0030225)
Nad+ nucleotidase, cyclic adp-ribose generating
(GO:0061809)
Nadp+ nucleosidase activity
(GO:0050135)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of t-helper 1 type immune response
(GO:0002826)
Negative regulation of type ii interferon production
(GO:0032689)
Plasma membrane
(GO:0005886)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-5 production
(GO:0032754)
Positive regulation of macrophage activation
(GO:0043032)
Protein binding
(GO:0005515)
Signal transduction
(GO:0007165)

Other Information

Proteins

Interleukin-1 receptor-like 1
Q5D095_MOUSE

Genular Protein ID: 2529717765

Symbol: ILRL1_MOUSE

Name: Interleukin-1 receptor-like 1

UniProtKB Accession Codes:

P14719 Q05208

Database IDs:

Citations:

PubMed ID: 2532153

Title: A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor.

PubMed ID: 2532153

DOI: 10.1016/0014-5793(89)81679-5

PubMed ID: 1832015

Title: Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping.

PubMed ID: 1832015

DOI: 10.1016/0167-4781(91)90029-l

PubMed ID: 2527364

Title: Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen.

PubMed ID: 2527364

DOI: 10.1073/pnas.86.15.5708

PubMed ID: 7916701

Title: Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1.

PubMed ID: 7916701

DOI: 10.1016/0014-5793(93)81333-u

PubMed ID: 8131748

Title: Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor.

PubMed ID: 8131748

DOI: 10.1002/j.1460-2075.1994.tb06367.x

PubMed ID: 17675517

Title: IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex.

PubMed ID: 17675517

DOI: 10.4049/jimmunol.179.4.2551

PubMed ID: 18003919

Title: IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells.

PubMed ID: 18003919

DOI: 10.1073/pnas.0705939104

PubMed ID: 18450470

Title: The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33.

PubMed ID: 18450470

DOI: 10.1016/j.cyto.2008.03.008

PubMed ID: 20200353

Title: The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells.

PubMed ID: 20200353

DOI: 10.1182/blood-2009-10-247411

PubMed ID: 21349253

Title: Production and functions of IL-33 in the central nervous system.

PubMed ID: 21349253

DOI: 10.1016/j.brainres.2011.02.045

PubMed ID: 22660580

Title: F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation.

PubMed ID: 22660580

DOI: 10.1038/ni.2341

PubMed ID: 29045903

Title: HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33.

PubMed ID: 29045903

DOI: 10.1016/j.immuni.2017.09.015

PubMed ID: 34644537

Title: IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.

PubMed ID: 34644537

DOI: 10.1016/j.immuni.2021.09.010

PubMed ID: 28930661

Title: IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor.

PubMed ID: 28930661

DOI: 10.1016/j.immuni.2017.08.004

Sequence Information:

Length: 567
Mass: 64801
Checksum: 9228CE227D95B0BC
Sequence:

MIDRQRMGLW ALAILTLPMY LTVTEGSKSS WGLENEALIV RCPQRGRSTY PVEWYYSDTN 
ESIPTQKRNR IFVSRDRLKF LPARVEDSGI YACVIRSPNL NKTGYLNVTI HKKPPSCNIP 
DYLMYSTVRG SDKNFKITCP TIDLYNWTAP VQWFKNCKAL QEPRFRAHRS YLFIDNVTHD 
DEGDYTCQFT HAENGTNYIV TATRSFTVEE KGFSMFPVIT NPPYNHTMEV EIGKPASIAC 
SACFGKGSHF LADVLWQINK TVVGNFGEAR IQEEEGRNES SSNDMDCLTS VLRITGVTEK 
DLSLEYDCLA LNLHGMIRHT IRLRRKQPID HRSIYYIVAG CSLLLMFINV LVIVLKVFWI 
EVALFWRDIV TPYKTRNDGK LYDAYIIYPR VFRGSAAGTH SVEYFVHHTL PDVLENKCGY 
KLCIYGRDLL PGQDAATVVE SSIQNSRRQV FVLAPHMMHS KEFAYEQEIA LHSALIQNNS 
KVILIEMEPL GEASRLQVGD LQDSLQHLVK IQGTIKWRED HVADKQSLSS KFWKHVRYQM 
PVPERASKTA SVAAPLSGKA CLDLKHF

Genular Protein ID: 2775956587

Symbol: Q5D095_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5D095

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 337
Mass: 38502
Checksum: 7574372722486926
Sequence:

MIDRQRMGLW ALAILTLPMY LTVTEGSKSS WGLENEALIV RCPQRGRSTY PVEWYYSDTN 
ESIPTQKRNR IFVSRDRLKF LPARVEDSGI YACVIRSPNL NKTGYLNVTI HKKPPSCNIP 
DYLMYSTVRG SDKNFKITCP TIDLYNWTAP VQWFKNCKAL QEPRFRAHRS YLFIDNVTHD 
DEGDYTCQFT HAENGTNYIV TATRSFTVEE KGFSMFPVIT NPPYNHTMEV EIGKPASIAC 
SACFGKGSHF LADVLWQINK TVVGNFGEAR IQEEEGRNES SSNDMDCLTS VLRITGVTEK 
DLSLEYDCLA LNLHGMIRHT IRLRRKQPSK ECPSHIA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Il1rl1

Associated with

Other Information

A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor. PubMed ID: 2532153

Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping. PubMed ID: 1832015

Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen. PubMed ID: 2527364

Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1. PubMed ID: 7916701

Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor. PubMed ID: 8131748

IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. PubMed ID: 17675517

IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. PubMed ID: 18003919

The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33. PubMed ID: 18450470

The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells. PubMed ID: 20200353

Production and functions of IL-33 in the central nervous system. PubMed ID: 21349253

F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. PubMed ID: 22660580

HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33. PubMed ID: 29045903

IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. PubMed ID: 34644537

IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor. PubMed ID: 28930661

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073