Genular: Defining Cellular Identity and Function

Details for: Ly96

Gene ID: 17087

Symbol: Ly96

Ensembl ID: ENSMUSG00000025779

Description: lymphocyte antigen 96

Associated with

Activation of irf3, irf7 mediated by tbk1, ikbke
(R-MMU-936964)
Apoptosis
(R-MMU-109581)
Caspase activation via death receptors in the presence of ligand
(R-MMU-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-MMU-5357769)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Heme signaling
(R-MMU-9707616)
Ikk complex recruitment mediated by rip1
(R-MMU-937041)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Irak2 mediated activation of tak1 complex upon tlr7/8 or 9 stimulation
(R-MMU-975163)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Programmed cell death
(R-MMU-5357801)
Regulation of tlr by endogenous ligand
(R-MMU-5686938)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Traf6-mediated induction of tak1 complex within tlr4 complex
(R-MMU-937072)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Trif-mediated programmed cell death
(R-MMU-2562578)
Cellular response to lipopolysaccharide
(GO:0071222)
Detection of lipopolysaccharide
(GO:0032497)
Extracellular region
(GO:0005576)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Lipopolysaccharide binding
(GO:0001530)
Lipopolysaccharide immune receptor activity
(GO:0001875)
Lipopolysaccharide receptor complex
(GO:0046696)
Plasma membrane
(GO:0005886)
Positive regulation of lipopolysaccharide-mediated signaling pathway
(GO:0031666)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Response to lipopolysaccharide
(GO:0032496)
Toll-like receptor 4 binding
(GO:0035662)
Toll-like receptor 4 signaling pathway
(GO:0034142)
Toll-like receptor signaling pathway
(GO:0002224)

Other Information

Proteins

Genular Protein ID: 2365839849

Symbol: LY96_MOUSE

Name: Lymphocyte antigen 96

UniProtKB Accession Codes:

Q9JHF9

Database IDs:

Citations:

PubMed ID: 10891475

Title: ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice.

PubMed ID: 10891475

PubMed ID: 10725698

Title: Cell surface expression and lipopolysaccaride signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages.

PubMed ID: 10725698

DOI: 10.4049/jimmunol.164.7.3471

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 20133493

Title: Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells.

PubMed ID: 20133493

DOI: 10.1093/intimm/dxq005

PubMed ID: 24380872

Title: The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.

PubMed ID: 24380872

DOI: 10.1093/intimm/dxt071

PubMed ID: 17803912

Title: Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran.

PubMed ID: 17803912

DOI: 10.1016/j.cell.2007.08.002

PubMed ID: 22532668

Title: Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2.

PubMed ID: 22532668

DOI: 10.1073/pnas.1201193109

Sequence Information:

Length: 160
Mass: 18394
Checksum: E224D17E5D5429E2
Sequence:

MLPFILFSTL LSPILTESEK QQWFCNSSDA IISYSYCDHL KFPISISSEP CIRLRGTNGF 
VHVEFIPRGN LKYLYFNLFI SVNSIELPKR KEVLCHGHDD DYSFCRALKG ETVNTSIPFS 
FEGILFPKGH YRCVAEAIAG DTEEKLFCLN FTIIHRRDVN

Genular Protein ID: 4065590552

Symbol: Q64HC9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q64HC9

Database IDs:

Sequence Information:

Length: 142
Mass: 16236
Checksum: 8078CB7D98E7207F
Sequence:

MLPFILFSTL LSPILTESEK QQWFCNSSDA IISYSYCDHL KFPISISSEP CVRLRGTNGF 
VHVEFIPKLP KRKEVLCHGH DDDYSFCRAL KGETVNTSIP FSFEGILFPK GHYRCVAEAI 
AGDTEEKLFC LNFTIIHRRD VN

Genular Protein ID: 3653116779

Symbol: A0A087WQZ9_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A087WQZ9

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 142
Mass: 16250
Checksum: 0BE8D5928616CF61
Sequence:

MLPFILFSTL LSPILTESEK QQWFCNSSDA IISYSYCDHL KFPISISSEP CIRLRGTNGF 
VHVEFIPKLP KRKEVLCHGH DDDYSFCRAL KGETVNTSIP FSFEGILFPK GHYRCVAEAI 
AGDTEEKLFC LNFTIIHRRD VN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ly96

Associated with

Other Information

ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice. PubMed ID: 10891475

Cell surface expression and lipopolysaccaride signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. PubMed ID: 10725698

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. PubMed ID: 20133493

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane. PubMed ID: 24380872

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. PubMed ID: 17803912

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2. PubMed ID: 22532668

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 10891475

PubMed ID: 10725698

PubMed ID: 16141072

PubMed ID: 20133493

PubMed ID: 24380872

PubMed ID: 17803912

PubMed ID: 22532668

PubMed ID: 19468303