Details for: Lyn
Associated with
Other Information
Genular Protein ID: 2528956011
Symbol: LYN_MOUSE
Name: Tyrosine-protein kinase Lyn
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1710766
Title: Alternatively spliced murine lyn mRNAs encode distinct proteins.
PubMed ID: 1710766
PubMed ID: 2017160
Title: Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus.
PubMed ID: 2017160
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2482828
Title: The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family.
PubMed ID: 2482828
PubMed ID: 1702903
Title: Association of B cell antigen receptor with protein tyrosine kinase Lyn.
PubMed ID: 1702903
PubMed ID: 8168489
Title: Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity.
PubMed ID: 8168489
PubMed ID: 15335855
Title: B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn.
PubMed ID: 15335855
PubMed ID: 7513017
Title: Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling.
PubMed ID: 7513017
PubMed ID: 8183901
Title: Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha.
PubMed ID: 8183901
PubMed ID: 8128248
Title: Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit.
PubMed ID: 8128248
PubMed ID: 7585947
Title: Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease.
PubMed ID: 7585947
PubMed ID: 7584145
Title: Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice.
PubMed ID: 7584145
PubMed ID: 7782294
Title: Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways.
PubMed ID: 7782294
PubMed ID: 8530369
Title: Autophosphorylation induces autoactivation and a decrease in the Src homology 2 domain accessibility of the Lyn protein kinase.
PubMed ID: 8530369
PubMed ID: 8621063
Title: Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase.
PubMed ID: 8621063
PubMed ID: 9064343
Title: Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice.
PubMed ID: 9064343
PubMed ID: 8629002
Title: Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.
PubMed ID: 8629002
PubMed ID: 9252121
Title: Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.
PubMed ID: 9252121
PubMed ID: 9036984
Title: Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells.
PubMed ID: 9036984
PubMed ID: 9573010
Title: Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.
PubMed ID: 9573010
PubMed ID: 9601638
Title: Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes.
PubMed ID: 9601638
PubMed ID: 9480991
Title: Inhibition of the B cell by CD22: a requirement for Lyn.
PubMed ID: 9480991
PubMed ID: 9547345
Title: A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals.
PubMed ID: 9547345
PubMed ID: 9469421
Title: Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation.
PubMed ID: 9469421
PubMed ID: 9590210
Title: The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation.
PubMed ID: 9590210
PubMed ID: 10594694
Title: Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings.
PubMed ID: 10594694
PubMed ID: 10415030
Title: CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells.
PubMed ID: 10415030
PubMed ID: 10327049
Title: Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1.
PubMed ID: 10327049
PubMed ID: 10672044
Title: Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common betac subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis.
PubMed ID: 10672044
PubMed ID: 10640270
Title: Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling.
PubMed ID: 10640270
PubMed ID: 11007759
Title: Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity.
PubMed ID: 11007759
PubMed ID: 11435302
Title: Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.
PubMed ID: 11435302
PubMed ID: 11672542
Title: Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.
PubMed ID: 11672542
PubMed ID: 11517336
Title: Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis.
PubMed ID: 11517336
PubMed ID: 12486102
Title: Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity.
PubMed ID: 12486102
DOI: 10.1084/jem.20020515
PubMed ID: 12077122
Title: Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase.
PubMed ID: 12077122
PubMed ID: 12681493
Title: Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells(1).
PubMed ID: 12681493
PubMed ID: 12874221
Title: The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
PubMed ID: 12874221
PubMed ID: 14726379
Title: Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors.
PubMed ID: 14726379
PubMed ID: 15304502
Title: Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl.
PubMed ID: 15304502
PubMed ID: 14525964
Title: The Src kinase Lyn is a negative regulator of mast cell proliferation.
PubMed ID: 14525964
DOI: 10.1189/jlb.0503224
PubMed ID: 16116174
Title: The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation.
PubMed ID: 16116174
PubMed ID: 16034130
Title: Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity.
PubMed ID: 16034130
PubMed ID: 16272347
Title: Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.
PubMed ID: 16272347
PubMed ID: 16249387
Title: LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.
PubMed ID: 16249387
PubMed ID: 16684964
Title: Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.
PubMed ID: 16684964
PubMed ID: 16731527
Title: Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation.
PubMed ID: 16731527
PubMed ID: 17233630
Title: Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets.
PubMed ID: 17233630
DOI: 10.1042/bj20061618
PubMed ID: 17640867
Title: Leupaxin negatively regulates B cell receptor signaling.
PubMed ID: 17640867
PubMed ID: 18034455
Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
PubMed ID: 18034455
DOI: 10.1021/pr0701254
PubMed ID: 19064729
Title: Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation.
PubMed ID: 19064729
PubMed ID: 19144319
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
PubMed ID: 19144319
PubMed ID: 19492092
Title: Erythropoietin down-regulates stem cell factor receptor (Kit) expression in the leukemic proerythroblast: role of Lyn kinase.
PubMed ID: 19492092
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20644716
Title: Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production.
PubMed ID: 20644716
PubMed ID: 20189992
Title: An important role of the SRC family kinase Lyn in stimulating platelet granule secretion.
PubMed ID: 20189992
PubMed ID: 20385881
Title: Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1.
PubMed ID: 20385881
PubMed ID: 22496641
Title: CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex.
PubMed ID: 22496641
PubMed ID: 28098138
Title: SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages.
PubMed ID: 28098138
DOI: 10.1038/ncomms14133
PubMed ID: 15489917
Title: Src-family kinases in B-cell development and signaling.
PubMed ID: 15489917
PubMed ID: 15664155
Title: Lyn tyrosine kinase: accentuating the positive and the negative.
PubMed ID: 15664155
PubMed ID: 15220000
Title: Src-family kinases: rheostats of immune cell signaling.
PubMed ID: 15220000
PubMed ID: 19290919
Title: Multiple roles of Lyn kinase in myeloid cell signaling and function.
PubMed ID: 19290919
PubMed ID: 18984583
Title: Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state.
PubMed ID: 18984583
Sequence Information:
- Length: 512
- Mass: 58812
- Checksum: FDA1D21CC90C50EC
- Sequence:
MGCIKSKRKD NLNDDEVDSK TQPVRNTDRT IYVRDPTSNK QQRPVPEFHL LPGQRFQTKD PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLSSKRE GFIPSNYVAK VNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DYDPMHGDVI KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQSDGLCR RLEKACISPK PQKPWDKDAW EIPRESIKLV KKLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD KLVRLYAVVT KEEPIYIITE FMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMSALSQGY RMPRMENCPD ELYDIMKMCW KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP
Genular Protein ID: 1355222647
Symbol: Q3U6Q5_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10349636
Title: High-efficiency full-length cDNA cloning.
PubMed ID: 10349636
PubMed ID: 11042159
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
PubMed ID: 11042159
DOI: 10.1101/gr.145100
PubMed ID: 11076861
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
PubMed ID: 11076861
DOI: 10.1101/gr.152600
PubMed ID: 11217851
Title: Functional annotation of a full-length mouse cDNA collection.
PubMed ID: 11217851
DOI: 10.1038/35055500
PubMed ID: 12466851
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
PubMed ID: 12466851
DOI: 10.1038/nature01266
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16141073
Title: Antisense Transcription in the Mammalian Transcriptome.
PubMed ID: 16141073
Sequence Information:
- Length: 491
- Mass: 56285
- Checksum: 2C82015D510B1F59
- Sequence:
MGCIKSKRKD NLNDDEVDSK TQPVPEFHLL PGQRFQTKDP EEQGDIVVAL YPYDGIHPDD LSFKKGEKMK VLEEHGEWWK AKSLSSKREG FIPSNYVAKV NTLETEEWFF KDITRKDAER QLLAPGNSAG AFLIRESETL KGSFSLSVRD YDPMHGDVIK HYKIRSLDNG GYYISPRITF PCISDMIKHY QKQSDGLCRR LEKACISPKP QKPWDKDAWE IPRESIKLVK KLGAGQFGEV WMGYYNNSTK VAVKTLKPGT MSVQAFLEEA NLMKTLQHDK LVRLYAVVTK EEPIYIITEF MAKGSLLDFL KSDEGGKVLL PKLIDFSAQI AEGMAYIERK NYIHRDLRAA NVLVSESLMC KIADFGLARV IEDNEYTARE GAKFPIKWTA PEAINFGCFT IKSDVWSFGI LLYEIVTYGK IPYPGRTNAD VMSALSQGYR MPRMENCPDE LYDIMKMCWK EKAEERPTFD YLQSVLDDFY TATEGQYQQQ P
Genular Protein ID: 2708329609
Symbol: Q8CEI0_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10349636
Title: High-efficiency full-length cDNA cloning.
PubMed ID: 10349636
PubMed ID: 11042159
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
PubMed ID: 11042159
DOI: 10.1101/gr.145100
PubMed ID: 11076861
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
PubMed ID: 11076861
DOI: 10.1101/gr.152600
PubMed ID: 11217851
Title: Functional annotation of a full-length mouse cDNA collection.
PubMed ID: 11217851
DOI: 10.1038/35055500
PubMed ID: 12466851
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
PubMed ID: 12466851
DOI: 10.1038/nature01266
PubMed ID: 16141073
Title: Antisense Transcription in the Mammalian Transcriptome.
PubMed ID: 16141073
Sequence Information:
- Length: 491
- Mass: 56310
- Checksum: 2C86DB46AA4B6AAB
- Sequence:
MGCIKSKRKD NLNDDEVDSK TQPVPEFHLL PGQRFQTKDP EEQGDIVVAL YPYDGIHPDD LSFKKGEKMK VLEEHGEWWK AKSLSSKREG FIPSNYVAKV NTLETEEWFF KDITRKDSER QLLAPGNSAG AFLIRESETL KGSFSLSVRD YDPMHGDVIK HYKIRSLDNG GYYISPRITF PCISDMIKHY QKQSDGLCRR LEKACISPKP QKPWDKDAWE IPRESIKLVK KLGAGQFGEV WMGYYNNSTK VAVKTLKPGT MSVQAFLEEA NLMKTLQHDK LVRLYAVVTK EEPIYIITEF MAKGSLLDFL KSDEGGKVLL PKLIDFSAQI AEGMAYIERK NYIHRDLRAA NVLVSESLMC KIADFGLARV IEDNEYTARE GAKFPIKWTA PEAINFGCFT IKSDVWSFGI LLYEIVTYGK IPYPGRTNAD VMSALSQGYR MPRMENCPDE LYDIMKMCWK EKAQERPTFD YLQSVLDDFY TATEGHYQQQ P
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.