Genular: Defining Cellular Identity and Function

Details for: Smad1

Gene ID: 17125

Symbol: Smad1

Ensembl ID: ENSMUSG00000031681

Description: SMAD family member 1

Associated with

Deubiquitination
(R-MMU-5688426)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Runx2 regulates bone development
(R-MMU-8941326)
Signaling by bmp
(R-MMU-201451)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by runx2
(R-MMU-8878166)
Ub-specific processing proteases
(R-MMU-5689880)
Anatomical structure morphogenesis
(GO:0009653)
Bmp signaling pathway
(GO:0030509)
Bone development
(GO:0060348)
Cardiac muscle cell proliferation
(GO:0060038)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Cartilage development
(GO:0051216)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Cellular response to organic cyclic compound
(GO:0071407)
Chromatin
(GO:0000785)
Co-smad binding
(GO:0070410)
Cytoplasm
(GO:0005737)
Dead/h-box rna helicase binding
(GO:0017151)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Gamete generation
(GO:0007276)
Heteromeric smad protein complex
(GO:0071144)
Hindbrain development
(GO:0030902)
Homeostatic process
(GO:0042592)
Homomeric smad protein complex
(GO:0071142)
I-smad binding
(GO:0070411)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Mapk cascade
(GO:0000165)
Mesodermal cell fate commitment
(GO:0001710)
Metal ion binding
(GO:0046872)
Midbrain development
(GO:0030901)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of muscle cell differentiation
(GO:0051148)
Nuclear inner membrane
(GO:0005637)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Ossification
(GO:0001503)
Osteoblast differentiation
(GO:0001649)
Osteoblast fate commitment
(GO:0002051)
Positive regulation of cartilage development
(GO:0061036)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of sprouting angiogenesis
(GO:1903672)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Primary mirna binding
(GO:0070878)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Smad protein signal transduction
(GO:0060395)
Transcription by rna polymerase ii
(GO:0006366)
Transcription regulator complex
(GO:0005667)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Ubiquitin protein ligase binding
(GO:0031625)
Ureteric bud development
(GO:0001657)

Other Information

Proteins

Mothers against decapentaplegic homolog 1

Genular Protein ID: 2695485088

Symbol: SMAD1_MOUSE

Name: Mothers against decapentaplegic homolog 1

UniProtKB Accession Codes:

P70340 P70442 Q6GT95 Q9CYK6

Database IDs:

Citations:

PubMed ID: 8799132

Title: Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.

PubMed ID: 8799132

DOI: 10.1073/pnas.93.17.8940

PubMed ID: 9076678

Title: Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse.

PubMed ID: 9076678

DOI: 10.1016/s0925-4773(96)00622-3

PubMed ID: 11111041

Title: Characterization of the mouse Smad1 gene and its expression pattern in adult mouse tissues.

PubMed ID: 11111041

DOI: 10.1016/s0378-1119(00)00396-6

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11094085

Title: Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.

PubMed ID: 11094085

DOI: 10.1128/mcb.20.24.9346-9355.2000

PubMed ID: 11566864

Title: Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation.

PubMed ID: 11566864

DOI: 10.1242/dev.128.18.3609

PubMed ID: 12370310

Title: Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.

PubMed ID: 12370310

DOI: 10.1128/mcb.22.21.7633-7644.2002

PubMed ID: 15329343

Title: SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer.

PubMed ID: 15329343

DOI: 10.1242/dev.01344

PubMed ID: 16115198

Title: Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein.

PubMed ID: 16115198

DOI: 10.1111/j.1365-2443.2005.00887.x

PubMed ID: 16801560

Title: Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells.

PubMed ID: 16801560

DOI: 10.1073/pnas.0506945103

PubMed ID: 18160706

Title: Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling.

PubMed ID: 18160706

DOI: 10.1128/mcb.01038-07

PubMed ID: 21420501

Title: Smad1 plays an essential role in bone development and postnatal bone formation.

PubMed ID: 21420501

DOI: 10.1016/j.joca.2011.03.004

PubMed ID: 21239498

Title: Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.

PubMed ID: 21239498

DOI: 10.1074/jbc.m110.179127

PubMed ID: 25755279

Title: Nuclear export of Smads by RanBP3L regulates bone morphogenetic protein signaling and mesenchymal stem cell differentiation.

PubMed ID: 25755279

DOI: 10.1128/mcb.00121-15

PubMed ID: 20147459

Title: Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-beta effectors.

PubMed ID: 20147459

DOI: 10.1093/nar/gkq046

PubMed ID: 34995814

Title: The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells.

PubMed ID: 34995814

DOI: 10.1016/j.cdev.2021.203763

PubMed ID: 35594155

Title: EGR1 plays an important role in BMP9-mediated osteoblast differentiation by promoting SMAD1/5 phosphorylation.

PubMed ID: 35594155

DOI: 10.1002/1873-3468.14407

Sequence Information:

Length: 465
Mass: 52157
Checksum: 07A56FBEE79A1C2A
Sequence:

MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE LEKALSCPGQ 
PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH HELKPLECCE FPFGSKQKEV 
CINPYHYKRV ESPVLPPVLV PRHSEYNPQH SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN 
SHPFPHSPNS SYPNSPGGSS STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMAQDGSQ 
PMDTNMMAPP LPAEISRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT 
DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC 
NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF ETVYELTKMC TIRMSFVKGW 
GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPHNP ISSVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smad1

Associated with

Other Information

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. PubMed ID: 8799132

Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse. PubMed ID: 9076678

Characterization of the mouse Smad1 gene and its expression pattern in adult mouse tissues. PubMed ID: 11111041

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. PubMed ID: 11094085

Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. PubMed ID: 11566864

Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. PubMed ID: 12370310

SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer. PubMed ID: 15329343

Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein. PubMed ID: 16115198

Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. PubMed ID: 16801560

Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling. PubMed ID: 18160706

Smad1 plays an essential role in bone development and postnatal bone formation. PubMed ID: 21420501

Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway. PubMed ID: 21239498

Nuclear export of Smads by RanBP3L regulates bone morphogenetic protein signaling and mesenchymal stem cell differentiation. PubMed ID: 25755279

Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-beta effectors. PubMed ID: 20147459

The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells. PubMed ID: 34995814

EGR1 plays an important role in BMP9-mediated osteoblast differentiation by promoting SMAD1/5 phosphorylation. PubMed ID: 35594155