Genular: Defining Cellular Identity and Function

Details for: Smad2

Gene ID: 17126

Symbol: Smad2

Ensembl ID: ENSMUSG00000024563

Description: SMAD family member 2

Associated with

Deubiquitination
(R-MMU-5688426)
Developmental biology
(R-MMU-1266738)
Downregulation of smad2/3:smad4 transcriptional activity
(R-MMU-2173795)
Downregulation of tgf-beta receptor signaling
(R-MMU-2173788)
Foxo-mediated transcription
(R-MMU-9614085)
Foxo-mediated transcription of cell cycle genes
(R-MMU-9617828)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by activin
(R-MMU-1502540)
Signaling by nodal
(R-MMU-1181150)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-MMU-2173796)
Tgf-beta receptor signaling activates smads
(R-MMU-2173789)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-MMU-2173793)
Ub-specific processing proteases
(R-MMU-5689880)
Activin receptor signaling pathway
(GO:0032924)
Adrenal gland development
(GO:0030325)
Anatomical structure morphogenesis
(GO:0009653)
Anterior/posterior pattern specification
(GO:0009952)
Aortic valve morphogenesis
(GO:0003180)
Cell differentiation
(GO:0030154)
Cell fate commitment
(GO:0045165)
Cell population proliferation
(GO:0008283)
Chromatin binding
(GO:0003682)
Co-smad binding
(GO:0070410)
Determination of left/right asymmetry in lateral mesoderm
(GO:0003140)
Disordered domain specific binding
(GO:0097718)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Embryonic pattern specification
(GO:0009880)
Endocardial cushion morphogenesis
(GO:0003203)
Endoderm development
(GO:0007492)
Endoderm formation
(GO:0001706)
Gastrulation
(GO:0007369)
Heart development
(GO:0007507)
I-smad binding
(GO:0070411)
Identical protein binding
(GO:0042802)
Insulin secretion
(GO:0030073)
Intracellular signal transduction
(GO:0035556)
In utero embryonic development
(GO:0001701)
Lung development
(GO:0030324)
Mesoderm formation
(GO:0001707)
Metal ion binding
(GO:0046872)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Nodal signaling pathway
(GO:0038092)
Organ growth
(GO:0035265)
Pancreas development
(GO:0031016)
Paraxial mesoderm morphogenesis
(GO:0048340)
Pattern specification process
(GO:0007389)
Phosphatase binding
(GO:0019902)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Pulmonary valve morphogenesis
(GO:0003184)
R-smad binding
(GO:0070412)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transforming growth factor beta receptor signaling pathway
(GO:0017015)
Response to glucose
(GO:0009749)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Smad binding
(GO:0046332)
Tau protein binding
(GO:0048156)
Transforming growth factor beta receptor binding
(GO:0005160)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Type i transforming growth factor beta receptor binding
(GO:0034713)
Ubiquitin protein ligase binding
(GO:0031625)
Ureteric bud development
(GO:0001657)
Zygotic specification of dorsal/ventral axis
(GO:0007352)

Other Information

Proteins

Mothers against decapentaplegic homolog 2

Genular Protein ID: 342958402

Symbol: SMAD2_MOUSE

Name: Mothers against decapentaplegic homolog 2

UniProtKB Accession Codes:

Q62432 Q6GU18 Q6VP00 Q9D8P6

Database IDs:

Citations:

PubMed ID: 8756346

Title: A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

PubMed ID: 8756346

DOI: 10.1101/gad.10.15.1880

PubMed ID: 9328171

Title: Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1): candidates for murine lung tumor resistance and suppressor genes.

PubMed ID: 9328171

DOI: 10.1093/carcin/18.9.1751

PubMed ID: 14701940

Title: Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells.

PubMed ID: 14701940

DOI: 10.1210/me.2003-0264

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10708952

Title: Functions of mammalian Smad genes as revealed by targeted gene disruption in mice.

PubMed ID: 10708952

DOI: 10.1016/s1359-6101(99)00028-3

PubMed ID: 12370310

Title: Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.

PubMed ID: 12370310

DOI: 10.1128/mcb.22.21.7633-7644.2002

PubMed ID: 15356634

Title: Cytoplasmic PML function in TGF-beta signalling.

PubMed ID: 15356634

DOI: 10.1038/nature02783

PubMed ID: 15221015

Title: Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

PubMed ID: 15221015

DOI: 10.1038/sj.onc.1207885

PubMed ID: 15630024

Title: Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.

PubMed ID: 15630024

DOI: 10.1101/gad.1243205

PubMed ID: 12672795

Title: Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation.

PubMed ID: 12672795

DOI: 10.1074/jbc.m300075200

PubMed ID: 10681527

Title: Identification and characterization of a PDZ protein that interacts with activin types II receptors.

PubMed ID: 10681527

DOI: 10.1074/jbc.275.8.5485

PubMed ID: 11094085

Title: Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.

PubMed ID: 11094085

DOI: 10.1128/mcb.20.24.9346-9355.2000

PubMed ID: 15496141

Title: NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.

PubMed ID: 15496141

DOI: 10.1042/bj20040738

PubMed ID: 17341133

Title: Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover.

PubMed ID: 17341133

DOI: 10.1371/journal.pbio.0050067

PubMed ID: 21145499

Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.

PubMed ID: 21145499

DOI: 10.1016/j.devcel.2010.11.012

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22781750

Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.

PubMed ID: 22781750

DOI: 10.1016/j.cellsig.2012.07.003

PubMed ID: 33548622

Title: Effects of transforming growth factor-beta1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level.

PubMed ID: 33548622

DOI: 10.1016/j.bbrc.2021.01.076

Sequence Information:

Length: 467
Mass: 52266
Checksum: 31A2A36D463DB3E9
Sequence:

MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE 
LEKAITTQNC NTKCVTIPST CSEIWGLSTA NTVDQWDTTG LYSFSEQTRS LDGRLQVSHR 
KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV 
PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS 
MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY ELNQRVGETF HASQPSLTVD 
GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL SDSAIFVQSP 
NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK 
GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smad2

Associated with

Other Information

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. PubMed ID: 8756346

Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1): candidates for murine lung tumor resistance and suppressor genes. PubMed ID: 9328171

Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells. PubMed ID: 14701940

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. PubMed ID: 10708952

Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. PubMed ID: 12370310

Cytoplasmic PML function in TGF-beta signalling. PubMed ID: 15356634

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). PubMed ID: 15221015

Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile. PubMed ID: 15630024

Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation. PubMed ID: 12672795

Identification and characterization of a PDZ protein that interacts with activin types II receptors. PubMed ID: 10681527

Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. PubMed ID: 11094085

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. PubMed ID: 15496141

Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover. PubMed ID: 17341133

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. PubMed ID: 21145499

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway. PubMed ID: 22781750

Effects of transforming growth factor-beta1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level. PubMed ID: 33548622