Genular: Defining Cellular Identity and Function

Details for: Smad3

Gene ID: 17127

Symbol: Smad3

Ensembl ID: ENSMUSG00000032402

Description: SMAD family member 3

Associated with

Deubiquitination
(R-MMU-5688426)
Developmental biology
(R-MMU-1266738)
Downregulation of smad2/3:smad4 transcriptional activity
(R-MMU-2173795)
Downregulation of tgf-beta receptor signaling
(R-MMU-2173788)
Foxo-mediated transcription
(R-MMU-9614085)
Foxo-mediated transcription of cell cycle genes
(R-MMU-9617828)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Runx3 regulates cdkn1a transcription
(R-MMU-8941855)
Signaling by activin
(R-MMU-1502540)
Signaling by nodal
(R-MMU-1181150)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-MMU-2173796)
Tgf-beta receptor signaling activates smads
(R-MMU-2173789)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-MMU-2173793)
Transcriptional regulation by runx3
(R-MMU-8878159)
Ub-specific processing proteases
(R-MMU-5689880)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Anatomical structure morphogenesis
(GO:0009653)
Apoptotic process
(GO:0006915)
Beta-catenin binding
(GO:0008013)
Bhlh transcription factor binding
(GO:0043425)
Cell population proliferation
(GO:0008283)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Co-smad binding
(GO:0070410)
Collagen binding
(GO:0005518)
Dead/h-box rna helicase binding
(GO:0017151)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity
(GO:0001217)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Embryonic pattern specification
(GO:0009880)
Endoderm development
(GO:0007492)
Enzyme binding
(GO:0019899)
Gastrulation
(GO:0007369)
Heart looping
(GO:0001947)
I-smad binding
(GO:0070411)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Immune system development
(GO:0002520)
In utero embryonic development
(GO:0001701)
Jnk cascade
(GO:0007254)
Liver development
(GO:0001889)
Mapk cascade
(GO:0000165)
Mesoderm formation
(GO:0001707)
Metal ion binding
(GO:0046872)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear glucocorticoid receptor binding
(GO:0035259)
Nuclear mineralocorticoid receptor binding
(GO:0031962)
Nuclear receptor binding
(GO:0016922)
Osteoblast development
(GO:0002076)
Osteoblast differentiation
(GO:0001649)
Phosphatase binding
(GO:0019902)
Positive regulation of gene expression
(GO:0010628)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
R-smad binding
(GO:0070412)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to hypoxia
(GO:0001666)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Skeletal system development
(GO:0001501)
Somitogenesis
(GO:0001756)
Sterol response element binding
(GO:0032810)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transcription corepressor binding
(GO:0001222)
Transforming growth factor beta receptor binding
(GO:0005160)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase binding
(GO:0031625)
Ureteric bud development
(GO:0001657)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Mothers against decapentaplegic homolog 3

Genular Protein ID: 2988312707

Symbol: SMAD3_MOUSE

Name: Mothers against decapentaplegic homolog 3

UniProtKB Accession Codes:

Q8BUN5 O09064 O09144 O14510 O35273 Q8BX84 Q92940 Q93002 Q9GKR4

Database IDs:

Citations:

PubMed ID: 10331191

Title: Cloning and studies of the mouse cDNA encoding Smad3.

PubMed ID: 10331191

DOI: 10.1292/jvms.61.213

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9380693

Title: Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells.

PubMed ID: 9380693

DOI: 10.1073/pnas.94.20.10669

PubMed ID: 10559937

Title: Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response.

PubMed ID: 10559937

DOI: 10.1038/12971

PubMed ID: 10681527

Title: Identification and characterization of a PDZ protein that interacts with activin types II receptors.

PubMed ID: 10681527

DOI: 10.1074/jbc.275.8.5485

PubMed ID: 11094085

Title: Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.

PubMed ID: 11094085

DOI: 10.1128/mcb.20.24.9346-9355.2000

PubMed ID: 11585338

Title: The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis.

PubMed ID: 11585338

DOI: 10.1359/jbmr.2001.16.10.1754

PubMed ID: 12370310

Title: Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.

PubMed ID: 12370310

DOI: 10.1128/mcb.22.21.7633-7644.2002

PubMed ID: 14617288

Title: Role of Smad3 in the hormonal modulation of in vivo wound healing responses.

PubMed ID: 14617288

DOI: 10.1046/j.1524-475x.2003.11614.x

PubMed ID: 14755691

Title: A LIM protein, Hic-5, functions as a potential coactivator for Sp1.

PubMed ID: 14755691

DOI: 10.1002/jcb.10754

PubMed ID: 15356634

Title: Cytoplasmic PML function in TGF-beta signalling.

PubMed ID: 15356634

DOI: 10.1038/nature02783

PubMed ID: 15221015

Title: Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

PubMed ID: 15221015

DOI: 10.1038/sj.onc.1207885

PubMed ID: 15496141

Title: NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.

PubMed ID: 15496141

DOI: 10.1042/bj20040738

PubMed ID: 16115198

Title: Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein.

PubMed ID: 16115198

DOI: 10.1111/j.1365-2443.2005.00887.x

PubMed ID: 17467076

Title: PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue.

PubMed ID: 17467076

DOI: 10.1016/j.bbamcr.2007.03.016

PubMed ID: 18039968

Title: Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.

PubMed ID: 18039968

DOI: 10.1242/dev.000026

PubMed ID: 19106105

Title: FoxL2 and Smad3 coordinately regulate follistatin gene transcription.

PubMed ID: 19106105

DOI: 10.1074/jbc.m806676200

PubMed ID: 21145499

Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.

PubMed ID: 21145499

DOI: 10.1016/j.devcel.2010.11.012

PubMed ID: 21035443

Title: Loss of Smad3 gives rise to poor soft callus formation and accelerates early fracture healing.

PubMed ID: 21035443

DOI: 10.1016/j.yexmp.2010.10.011

PubMed ID: 22781750

Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.

PubMed ID: 22781750

DOI: 10.1016/j.cellsig.2012.07.003

PubMed ID: 17341133

Title: Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover.

PubMed ID: 17341133

DOI: 10.1371/journal.pbio.0050067

Sequence Information:

Length: 425
Mass: 48081
Checksum: 46DF5E8B371321AC
Sequence:

MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE LEKAITTQNV 
NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELRAMELCE FAFNMKKDEV 
CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF PPLDDYSHSI PENTNFPAGI EPQSNIPETP 
PPGYLSEDGE TSDHQMNHSM DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL 
NQRVGETFHA SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG 
GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA LLAQSVNQGF 
EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL NGPLQWLDKV LTQMGSPSIR 
CSSVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smad3

Associated with

Other Information

Cloning and studies of the mouse cDNA encoding Smad3. PubMed ID: 10331191

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. PubMed ID: 9380693

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. PubMed ID: 10559937

Identification and characterization of a PDZ protein that interacts with activin types II receptors. PubMed ID: 10681527

Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. PubMed ID: 11094085

The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. PubMed ID: 11585338

Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. PubMed ID: 12370310

Role of Smad3 in the hormonal modulation of in vivo wound healing responses. PubMed ID: 14617288

A LIM protein, Hic-5, functions as a potential coactivator for Sp1. PubMed ID: 14755691

Cytoplasmic PML function in TGF-beta signalling. PubMed ID: 15356634

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). PubMed ID: 15221015

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. PubMed ID: 15496141

Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein. PubMed ID: 16115198

PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue. PubMed ID: 17467076

Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination. PubMed ID: 18039968

FoxL2 and Smad3 coordinately regulate follistatin gene transcription. PubMed ID: 19106105

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. PubMed ID: 21145499

Loss of Smad3 gives rise to poor soft callus formation and accelerates early fracture healing. PubMed ID: 21035443

Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway. PubMed ID: 22781750

Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover. PubMed ID: 17341133