Genular: Defining Cellular Identity and Function

Details for: Smad4

Gene ID: 17128

Symbol: Smad4

Ensembl ID: ENSMUSG00000024515

Description: SMAD family member 4

Associated with

Deubiquitination
(R-MMU-5688426)
Developmental biology
(R-MMU-1266738)
Downregulation of smad2/3:smad4 transcriptional activity
(R-MMU-2173795)
Foxo-mediated transcription
(R-MMU-9614085)
Foxo-mediated transcription of cell cycle genes
(R-MMU-9617828)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Runx2 regulates bone development
(R-MMU-8941326)
Runx3 regulates cdkn1a transcription
(R-MMU-8941855)
Signaling by activin
(R-MMU-1502540)
Signaling by bmp
(R-MMU-201451)
Signaling by nodal
(R-MMU-1181150)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-MMU-2173796)
Tgf-beta receptor signaling activates smads
(R-MMU-2173789)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-MMU-2173793)
Transcriptional regulation by runx2
(R-MMU-8878166)
Transcriptional regulation by runx3
(R-MMU-8878159)
Ub-specific processing proteases
(R-MMU-5689880)
Anatomical structure morphogenesis
(GO:0009653)
Anterior/posterior pattern specification
(GO:0009952)
Atrioventricular valve formation
(GO:0003190)
Axon guidance
(GO:0007411)
Brainstem development
(GO:0003360)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cardiac septum development
(GO:0003279)
Cell population proliferation
(GO:0008283)
Chromatin binding
(GO:0003682)
Collagen binding
(GO:0005518)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Endoderm development
(GO:0007492)
Epithelial cell migration
(GO:0010631)
Epithelial to mesenchymal transition
(GO:0001837)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Female gonad development
(GO:0008585)
Filamin binding
(GO:0031005)
Gastrulation
(GO:0007369)
Gastrulation with mouth forming second
(GO:0001702)
I-smad binding
(GO:0070411)
Identical protein binding
(GO:0042802)
Intracellular iron ion homeostasis
(GO:0006879)
In utero embryonic development
(GO:0001701)
Kidney development
(GO:0001822)
Left ventricular cardiac muscle tissue morphogenesis
(GO:0003220)
Male gonad development
(GO:0008584)
Mesoderm development
(GO:0007498)
Metal ion binding
(GO:0046872)
Negative regulation of cardiac muscle hypertrophy
(GO:0010614)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Osteoblast differentiation
(GO:0001649)
Outflow tract septum morphogenesis
(GO:0003148)
Ovarian follicle development
(GO:0001541)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of cell proliferation involved in heart valve morphogenesis
(GO:0003251)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gene expression
(GO:0010628)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
R-smad binding
(GO:0070412)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to hypoxia
(GO:0001666)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Single fertilization
(GO:0007338)
Smad binding
(GO:0046332)
Spermatogenesis
(GO:0007283)
Sulfate binding
(GO:0043199)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transcription corepressor binding
(GO:0001222)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)

Other Information

Proteins

Mothers against decapentaplegic homolog 4

Genular Protein ID: 109902833

Symbol: SMAD4_MOUSE

Name: Mothers against decapentaplegic homolog 4

UniProtKB Accession Codes:

P97471 Q6GTP6 Q9CW56

Database IDs:

Citations:

PubMed ID: 9166592

Title: Sequence and chromosomal mapping of the mouse homolog (Madh4) of the human DPC4/MADH4 gene.

PubMed ID: 9166592

DOI: 10.1007/s003359900465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 12370310

Title: Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.

PubMed ID: 12370310

DOI: 10.1128/mcb.22.21.7633-7644.2002

PubMed ID: 15329343

Title: SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer.

PubMed ID: 15329343

DOI: 10.1242/dev.01344

PubMed ID: 16115198

Title: Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein.

PubMed ID: 16115198

DOI: 10.1111/j.1365-2443.2005.00887.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21145499

Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.

PubMed ID: 21145499

DOI: 10.1016/j.devcel.2010.11.012

PubMed ID: 24076600

Title: BMP signaling controls muscle mass.

PubMed ID: 24076600

DOI: 10.1038/ng.2772

PubMed ID: 20147459

Title: Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-beta effectors.

PubMed ID: 20147459

DOI: 10.1093/nar/gkq046

Sequence Information:

Length: 551
Mass: 60342
Checksum: 4FBDF5DED4442F86
Sequence:

MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA 
ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD 
LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPSMLVKDE YVHDFEGQPS LPTEGHSIQT 
IQHPPSNRAS TETYSAPALL APAESNATST TNFPNIPVAS TSQPASILAG SHSEGLLQIA 
SGPQPGQQQN GFTAQPATYH HNSTTTWTGS RTAPYTPNLP HHQNGHLQHH PPMPPHPGHY 
WPVHNELAFQ PPISNHPAPE YWCSIAYFEM DVQVGETFKV PSSCPVVTVD GYVDPSGGDR 
FCLGQLSNVH RTEAIERARL HIGKGVQLEC KGEGDVWVRC LSDHAVFVQS YYLDREAGRA 
PGDAVHKIYP SAYIKVFDLR QCHRQMQQQA ATAQAAAAAQ AAAVAGNIPG PGSVGGIAPA 
ISLSAAAGIG VDDLRRLCIL RMSFVKGWGP DYPRQSIKET PCWIEIHLHR ALQLLDEVLH 
TMPIADPQPL D

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smad4

Associated with

Other Information

Sequence and chromosomal mapping of the mouse homolog (Madh4) of the human DPC4/MADH4 gene. PubMed ID: 9166592

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. PubMed ID: 12370310

SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer. PubMed ID: 15329343

Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein. PubMed ID: 16115198

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. PubMed ID: 21145499

BMP signaling controls muscle mass. PubMed ID: 24076600

Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-beta effectors. PubMed ID: 20147459