Genular: Defining Cellular Identity and Function

Details for: Smad5

Gene ID: 17129

Symbol: Smad5

Ensembl ID: ENSMUSG00000021540

Description: SMAD family member 5

Associated with

Signaling by bmp
(R-MMU-201451)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Anatomical structure morphogenesis
(GO:0009653)
Angiogenesis
(GO:0001525)
Bmp signaling pathway
(GO:0030509)
Bone development
(GO:0060348)
Cardiac muscle contraction
(GO:0060048)
Cartilage development
(GO:0051216)
Cell differentiation
(GO:0030154)
Cellular response to organic cyclic compound
(GO:0071407)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dead/h-box rna helicase binding
(GO:0017151)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Erythrocyte differentiation
(GO:0030218)
Germ cell development
(GO:0007281)
Heteromeric smad protein complex
(GO:0071144)
I-smad binding
(GO:0070411)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Mullerian duct regression
(GO:0001880)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of fas signaling pathway
(GO:1902045)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Osteoblast fate commitment
(GO:0002051)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)
Smad protein signal transduction
(GO:0060395)
Transcription regulator complex
(GO:0005667)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Ubiquitin protein ligase binding
(GO:0031625)
Ureteric bud development
(GO:0001657)

Other Information

Proteins

Mothers against decapentaplegic homolog 5

Genular Protein ID: 1225080863

Symbol: SMAD5_MOUSE

Name: Mothers against decapentaplegic homolog 5

UniProtKB Accession Codes:

P97454 P70341 Q810K0

Database IDs:

Citations:

PubMed ID: 8799132

Title: Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.

PubMed ID: 8799132

DOI: 10.1073/pnas.93.17.8940

PubMed ID: 9076683

Title: The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation.

PubMed ID: 9076683

DOI: 10.1016/s0925-4773(96)00629-6

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10079220

Title: Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5.

PubMed ID: 10079220

DOI: 10.1242/dev.126.8.1571

PubMed ID: 10708952

Title: Functions of mammalian Smad genes as revealed by targeted gene disruption in mice.

PubMed ID: 10708952

DOI: 10.1016/s1359-6101(99)00028-3

PubMed ID: 12370310

Title: Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.

PubMed ID: 12370310

DOI: 10.1128/mcb.22.21.7633-7644.2002

PubMed ID: 12393578

Title: Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis.

PubMed ID: 12393578

DOI: 10.1182/blood-2002-02-0398

PubMed ID: 15221015

Title: Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

PubMed ID: 15221015

DOI: 10.1038/sj.onc.1207885

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21239498

Title: Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.

PubMed ID: 21239498

DOI: 10.1074/jbc.m110.179127

PubMed ID: 26304548

Title: Structural basis for the Smad5 MH1 domain to recognize different DNA sequences.

PubMed ID: 26304548

DOI: 10.1093/nar/gkv848

Sequence Information:

Length: 465
Mass: 52172
Checksum: D66B638DA76BC20B
Sequence:

MTSMASLFSF TSPAVKRLLG WKQGDEEEKW AEKAVDALVK KLKKKKGAME ELEKALSSPG 
QPSKCVTIPR SLDGRLQVSH RKGLPHVIYC RVWRWPDLQS HHELKPLDIC EFPFGSKQKE 
VCINPYHYKR VESPVLPPVL VPRHNEFNPQ HSLLVQFRNL SHNEPHMPQN ATFPDSFHQP 
NNAPFPLSPN SPYPPSPASS TYPNSPASSG PGSPFQLPAD TPPPAYMPPD DQMAPDNSQP 
MDTSSNMIPQ TMPSISSRDV QPVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT 
DPSNNKSRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC 
NFHHGFHPTT VCKIPSSCSL KIFNNQEFAQ LLAQSVNHGF EAVYELTKMC TIRMSFVKGW 
GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPLNP ISSVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smad5

Associated with

Other Information

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. PubMed ID: 8799132

The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation. PubMed ID: 9076683

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. PubMed ID: 10079220

Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. PubMed ID: 10708952

Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. PubMed ID: 12370310

Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis. PubMed ID: 12393578

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). PubMed ID: 15221015

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway. PubMed ID: 21239498

Structural basis for the Smad5 MH1 domain to recognize different DNA sequences. PubMed ID: 26304548