Details for: Smad6

Gene ID: 17130

Symbol: Smad6

Ensembl ID: ENSMUSG00000036867

Description: SMAD family member 6

Associated with

Other Information

Genular Protein ID: 4092974041

Symbol: SMAD6_MOUSE

Name: Mothers against decapentaplegic homolog 6

UniProtKB Accession Codes:

O35182 Q9CW62

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 55 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9335505

Title: Smad6 inhibits signalling by the TGF-beta superfamily.

PubMed ID: 9335505

DOI: 10.1038/39355

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 14657019

Title: Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7.

PubMed ID: 14657019

DOI: 10.1093/emboj/cdg632

PubMed ID: 15221015

Title: Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

PubMed ID: 15221015

DOI: 10.1038/sj.onc.1207885

PubMed ID: 15496141

Title: NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.

PubMed ID: 15496141

DOI: 10.1042/bj20040738

PubMed ID: 16951688

Title: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1.

PubMed ID: 16951688

DOI: 10.1038/ni1383

PubMed ID: 23747011

Title: Arginine Methylation Initiates BMP-Induced Smad Signaling.

PubMed ID: 23747011

DOI: 10.1016/j.molcel.2013.05.004

PubMed ID: 23610558

Title: Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension.

PubMed ID: 23610558

DOI: 10.1371/journal.pbio.1001538

Sequence Information:

  • Length: 495
  • Mass: 53714
  • Checksum: D9282D42B120C507
  • Sequence:
    • MFRSKRSGLV RRLWRSRVVP DREEGSGGGG GVDEDGSLGS RAEPAPRARE GGGCSRSEVR 
SVAPRRPRDA VGPRGAAIAG RRRRTGGLPR PVSESGAGAG GSPLDVAEPG GPGWLPESDC 
ETVTCCLFSE RDAAGAPRDS GDPQARQSPE PEEGGGPRSR EARSRLLLLE QELKTVTYSL 
LKRLKERSLD TLLEAVESRG GVPGGCVLVP RADLRLGGQP APPQLLLGRL FRWPDLQHAV 
ELKPLCGCHS FTAAADGPTV CCNPYHFSRL CGPESPPPPY SRLSPPDQYK PLDLSDSTLS 
YTETEATNSL ITAPGEFSDA SMSPDATKPS HWCSVAYWEH RTRVGRLYAV YDQAVSIFYD 
LPQGSGFCLG QLNLEQRSES VRRTRSKIGF GILLSKEPDG VWAYNRGEHP IFVNSPTLDA 
PGGRALVVRK VPPGYSIKVF DFERSGLLQH ADAAHGPYDP HSVRISFAKG WGPCYSRQFI 
TSCPCWLEIL LNNHR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.