Genular: Defining Cellular Identity and Function

Details for: Smad6

Gene ID: 17130

Symbol: Smad6

Ensembl ID: ENSMUSG00000036867

Description: SMAD family member 6

Associated with

Signaling by bmp
(R-MMU-201451)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Anatomical structure morphogenesis
(GO:0009653)
Aorta development
(GO:0035904)
Aortic valve morphogenesis
(GO:0003180)
Bmp signaling pathway
(GO:0030509)
Cardiac vascular smooth muscle cell development
(GO:0060948)
Cell-substrate adhesion
(GO:0031589)
Cell differentiation
(GO:0030154)
Chromatin binding
(GO:0003682)
Co-smad binding
(GO:0070410)
Coronary vasculature development
(GO:0060976)
Coronary vasculature morphogenesis
(GO:0060977)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Fat cell differentiation
(GO:0045444)
Golgi apparatus
(GO:0005794)
Heart valve development
(GO:0003170)
Heteromeric smad protein complex
(GO:0071144)
I-smad binding
(GO:0070411)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Metal ion binding
(GO:0046872)
Mitral valve morphogenesis
(GO:0003183)
Negative regulation of activin receptor signaling pathway
(GO:0032926)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of ossification
(GO:0030279)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of smad protein signal transduction
(GO:0060392)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Outflow tract septum morphogenesis
(GO:0003148)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of vasoconstriction
(GO:0045907)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein sequestering activity
(GO:0140311)
Pulmonary valve morphogenesis
(GO:0003184)
R-smad binding
(GO:0070412)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to lipopolysaccharide
(GO:0032496)
Smad protein signal transduction
(GO:0060395)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator complex
(GO:0005667)
Transcription regulator inhibitor activity
(GO:0140416)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Type i activin receptor binding
(GO:0070698)
Type i transforming growth factor beta receptor binding
(GO:0034713)
Ubiquitin protein ligase binding
(GO:0031625)
Ureteric bud development
(GO:0001657)
Vasoconstriction
(GO:0042310)
Ventricular septum development
(GO:0003281)
Zygotic specification of dorsal/ventral axis
(GO:0007352)

Other Information

Proteins

Mothers against decapentaplegic homolog 6

Genular Protein ID: 4092974041

Symbol: SMAD6_MOUSE

Name: Mothers against decapentaplegic homolog 6

UniProtKB Accession Codes:

O35182 Q9CW62

Database IDs:

Citations:

PubMed ID: 9335505

Title: Smad6 inhibits signalling by the TGF-beta superfamily.

PubMed ID: 9335505

DOI: 10.1038/39355

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 14657019

Title: Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7.

PubMed ID: 14657019

DOI: 10.1093/emboj/cdg632

PubMed ID: 15221015

Title: Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

PubMed ID: 15221015

DOI: 10.1038/sj.onc.1207885

PubMed ID: 15496141

Title: NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.

PubMed ID: 15496141

DOI: 10.1042/bj20040738

PubMed ID: 16951688

Title: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1.

PubMed ID: 16951688

DOI: 10.1038/ni1383

PubMed ID: 23747011

Title: Arginine Methylation Initiates BMP-Induced Smad Signaling.

PubMed ID: 23747011

DOI: 10.1016/j.molcel.2013.05.004

PubMed ID: 23610558

Title: Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension.

PubMed ID: 23610558

DOI: 10.1371/journal.pbio.1001538

Sequence Information:

Length: 495
Mass: 53714
Checksum: D9282D42B120C507
Sequence:

MFRSKRSGLV RRLWRSRVVP DREEGSGGGG GVDEDGSLGS RAEPAPRARE GGGCSRSEVR 
SVAPRRPRDA VGPRGAAIAG RRRRTGGLPR PVSESGAGAG GSPLDVAEPG GPGWLPESDC 
ETVTCCLFSE RDAAGAPRDS GDPQARQSPE PEEGGGPRSR EARSRLLLLE QELKTVTYSL 
LKRLKERSLD TLLEAVESRG GVPGGCVLVP RADLRLGGQP APPQLLLGRL FRWPDLQHAV 
ELKPLCGCHS FTAAADGPTV CCNPYHFSRL CGPESPPPPY SRLSPPDQYK PLDLSDSTLS 
YTETEATNSL ITAPGEFSDA SMSPDATKPS HWCSVAYWEH RTRVGRLYAV YDQAVSIFYD 
LPQGSGFCLG QLNLEQRSES VRRTRSKIGF GILLSKEPDG VWAYNRGEHP IFVNSPTLDA 
PGGRALVVRK VPPGYSIKVF DFERSGLLQH ADAAHGPYDP HSVRISFAKG WGPCYSRQFI 
TSCPCWLEIL LNNHR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smad6

Associated with

Other Information

Smad6 inhibits signalling by the TGF-beta superfamily. PubMed ID: 9335505

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7. PubMed ID: 14657019

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). PubMed ID: 15221015

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. PubMed ID: 15496141

Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1. PubMed ID: 16951688

Arginine Methylation Initiates BMP-Induced Smad Signaling. PubMed ID: 23747011

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PubMed ID: 23610558