Genular: Defining Cellular Identity and Function

Details for: Smad7

Gene ID: 17131

Symbol: Smad7

Ensembl ID: ENSMUSG00000025880

Description: SMAD family member 7

Associated with

Deubiquitination
(R-MMU-5688426)
Downregulation of tgf-beta receptor signaling
(R-MMU-2173788)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by bmp
(R-MMU-201451)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-MMU-2173796)
Tgf-beta receptor signaling activates smads
(R-MMU-2173789)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-MMU-2173793)
Ub-specific processing proteases
(R-MMU-5689880)
Activin receptor binding
(GO:0070697)
Adherens junction
(GO:0005912)
Adherens junction assembly
(GO:0034333)
Anatomical structure morphogenesis
(GO:0009653)
Artery morphogenesis
(GO:0048844)
Beta-catenin binding
(GO:0008013)
Cell differentiation
(GO:0030154)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Centrosome
(GO:0005813)
Collagen binding
(GO:0005518)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Fibrillar center
(GO:0001650)
Heteromeric smad protein complex
(GO:0071144)
I-smad binding
(GO:0070411)
Intracellular signal transduction
(GO:0035556)
Metal ion binding
(GO:0046872)
Negative regulation of activin receptor signaling pathway
(GO:0032926)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of chondrocyte proliferation
(GO:1902731)
Negative regulation of ossification
(GO:0030279)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of peptidyl-threonine phosphorylation
(GO:0010801)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of smad protein signal transduction
(GO:0060392)
Negative regulation of t-helper 17 cell differentiation
(GO:2000320)
Negative regulation of t-helper 17 type immune response
(GO:2000317)
Negative regulation of t cell cytokine production
(GO:0002725)
Negative regulation of transcription by competitive promoter binding
(GO:0010944)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Negative regulation of ubiquitin-protein transferase activity
(GO:0051444)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of cell-cell adhesion
(GO:0022409)
Positive regulation of chondrocyte hypertrophy
(GO:1903043)
Protein-containing complex
(GO:0032991)
Protein-containing complex localization
(GO:0031503)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Regulation of cardiac muscle contraction
(GO:0055117)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of epithelial to mesenchymal transition
(GO:0010717)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of transforming growth factor beta receptor signaling pathway
(GO:0017015)
Regulation of ventricular cardiac muscle cell membrane depolarization
(GO:0060373)
Smad protein signal transduction
(GO:0060395)
Transcription corepressor activity
(GO:0003714)
Transcription regulator complex
(GO:0005667)
Transcription regulator inhibitor activity
(GO:0140416)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Type i transforming growth factor beta receptor binding
(GO:0034713)
Ubiquitin ligase-substrate adaptor activity
(GO:1990756)
Ubiquitin protein ligase binding
(GO:0031625)
Ureteric bud development
(GO:0001657)
Ventricular cardiac muscle tissue morphogenesis
(GO:0055010)
Ventricular septum morphogenesis
(GO:0060412)

Other Information

Proteins

Mothers against decapentaplegic homolog 7

Genular Protein ID: 2654133411

Symbol: SMAD7_MOUSE

Name: Mothers against decapentaplegic homolog 7

UniProtKB Accession Codes:

O35253 O88709

Database IDs:

Citations:

PubMed ID: 9335507

Title: Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.

PubMed ID: 9335507

DOI: 10.1038/39369

PubMed ID: 10828018

Title: Smad7 selectively interferes with different pathways of activin signaling and inhibits erythroid leukemia cell differentiation.

PubMed ID: 10828018

PubMed ID: 11278814

Title: Phosphorylation of Smad7 at Ser-249 does not interfere with its inhibitory role in transforming growth factor-beta-dependent signaling but affects Smad7-dependent transcriptional activation.

PubMed ID: 11278814

DOI: 10.1074/jbc.m011019200

PubMed ID: 14657019

Title: Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7.

PubMed ID: 14657019

DOI: 10.1093/emboj/cdg632

PubMed ID: 15221015

Title: Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

PubMed ID: 15221015

DOI: 10.1038/sj.onc.1207885

PubMed ID: 15496141

Title: NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.

PubMed ID: 15496141

DOI: 10.1042/bj20040738

PubMed ID: 23610558

Title: Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension.

PubMed ID: 23610558

DOI: 10.1371/journal.pbio.1001538

Sequence Information:

Length: 426
Mass: 46442
Checksum: BEEE751371C0E0CF
Sequence:

MFRTKRSALV RRLWRSRAPG GEDEEEGVGG GGGGGELRGE GATDGRAYGA GGGGAGRAGC 
CLGKAVRGAK GHHHPHPPTS GAGAAGGAEA DLKALTHSVL KKLKERQLEL LLQAVESRGG 
TRTACLLLPG RLDCRLGPGA PASAQPAQPP SSYSLPLLLC KVFRWPDLRH SSEVKRLCCC 
ESYGKINPEL VCCNPHHLSR LCELESPPPP YSRYPMDFLK PTAGCPDAVP SSAETGGTNY 
LAPGGLSDSQ LLLEPGDRSH WCVVAYWEEK TRVGRLYCVQ EPSLDIFYDL PQGNGFCLGQ 
LNSDNKSQLV QKVRSKIGCG IQLTREVDGV WVYNRSSYPI FIKSATLDNP DSRTLLVHKV 
FPGFSIKAFD YEKAYSLQRP NDHEFMQQPW TGFTVQISFV KGWGQCYTRQ FISSCPCWLE 
VIFNSR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smad7

Associated with

Other Information

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. PubMed ID: 9335507

Smad7 selectively interferes with different pathways of activin signaling and inhibits erythroid leukemia cell differentiation. PubMed ID: 10828018

Phosphorylation of Smad7 at Ser-249 does not interfere with its inhibitory role in transforming growth factor-beta-dependent signaling but affects Smad7-dependent transcriptional activation. PubMed ID: 11278814

Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7. PubMed ID: 14657019

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). PubMed ID: 15221015

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. PubMed ID: 15496141

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PubMed ID: 23610558