Genular: Defining Cellular Identity and Function

Details for: Maf

Gene ID: 17132

Symbol: Maf

Ensembl ID: ENSMUSG00000055435

Description: MAF bZIP transcription factor

Associated with

Cell development
(GO:0048468)
Cytokine production
(GO:0001816)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Identical protein binding
(GO:0042802)
Inner ear development
(GO:0048839)
Lens development in camera-type eye
(GO:0002088)
Lens fiber cell differentiation
(GO:0070306)
Megakaryocyte differentiation
(GO:0030219)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of chondrocyte differentiation
(GO:0032330)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)

Other Information

Proteins

Transcription factor Maf

Genular Protein ID: 3040148976

Symbol: MAF_MOUSE

Name: Transcription factor Maf

UniProtKB Accession Codes:

P54843 Q3V1Z2 Q4QY62

Database IDs:

Citations:

PubMed ID: 7799931

Title: The maf proto-oncogene stimulates transcription from multiple sites in a promoter that directs Purkinje neuron-specific gene expression.

PubMed ID: 7799931

DOI: 10.1128/mcb.15.1.246

PubMed ID: 14707122

Title: Mafs, Prox1, and Pax6 can regulate chicken betaB1-crystallin gene expression.

PubMed ID: 14707122

DOI: 10.1074/jbc.m312414200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 9070273

Title: USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity.

PubMed ID: 9070273

DOI: 10.1006/bbrc.1997.6097

PubMed ID: 9566892

Title: c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation.

PubMed ID: 9566892

DOI: 10.1128/mcb.18.5.2729

PubMed ID: 10403649

Title: The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines.

PubMed ID: 10403649

DOI: 10.1016/s1074-7613(00)80073-4

PubMed ID: 10383433

Title: Regulation of lens fiber cell differentiation by transcription factor c-Maf.

PubMed ID: 10383433

DOI: 10.1074/jbc.274.27.19254

PubMed ID: 10097114

Title: Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development.

PubMed ID: 10097114

DOI: 10.1073/pnas.96.7.3781

PubMed ID: 10603348

Title: Regulation of mouse lens fiber cell development and differentiation by the Maf gene.

PubMed ID: 10603348

DOI: 10.1242/dev.127.2.307

PubMed ID: 11943779

Title: CREB-binding protein/p300 co-activation of crystallin gene expression.

PubMed ID: 11943779

DOI: 10.1074/jbc.m201821200

PubMed ID: 14512017

Title: Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development.

PubMed ID: 14512017

DOI: 10.1016/s0012-1606(03)00324-5

PubMed ID: 15249232

Title: Developmental contribution of c-maf in the kidney: distribution and developmental study of c-maf mRNA in normal mice kidney and histological study of c-maf knockout mice kidney and liver.

PubMed ID: 15249232

DOI: 10.1016/j.bbrc.2004.05.222

PubMed ID: 17823980

Title: c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells.

PubMed ID: 17823980

DOI: 10.1002/eji.200636979

PubMed ID: 17897790

Title: CD13/APN transcription is regulated by the proto-oncogene c-Maf via an atypical response element.

PubMed ID: 17897790

DOI: 10.1016/j.gene.2007.08.010

PubMed ID: 17901057

Title: Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression.

PubMed ID: 17901057

DOI: 10.1074/jbc.m702795200

PubMed ID: 19143053

Title: A new MAFia in cancer.

PubMed ID: 19143053

DOI: 10.1038/nrc2460

Sequence Information:

Length: 370
Mass: 38435
Checksum: 1E8722C8287AAAC9
Sequence:

MASELAMNNS DLPTSPLAME YVNDFDLMKF EVKKEPVETD RIISQCGRLI AGGSLSSTPM 
STPCSSVPPS PSFSAPSPGS GSEQKAHLED YYWMTGYPQQ LNPEALGFSP EDAVEALISN 
SHQLQGGFDG YARGAQQLAA AAGAGAGASL GGSGEEMGPA AAVVSAVIAA AAAQSGAAPH 
YHHHHHHAAG HHHHPTAGAP GAAGGASASA SGAGGAGGGG PASAGGGGGG GGGGGTAGAG 
GALHPHHAAG GLHFDDRFSD EQLVTMSVRE LNRQLRGVSK EEVIRLKQKR RTLKNRGYAQ 
SCRFKRVQQR HVLESEKNQL LQQVDHLKQE ISRLVRERDA YKEKYEKLVS NGFRENGSSS 
DNPSSPEFFM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Maf

Associated with

Other Information

The maf proto-oncogene stimulates transcription from multiple sites in a promoter that directs Purkinje neuron-specific gene expression. PubMed ID: 7799931

Mafs, Prox1, and Pax6 can regulate chicken betaB1-crystallin gene expression. PubMed ID: 14707122

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity. PubMed ID: 9070273

c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation. PubMed ID: 9566892

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. PubMed ID: 10403649

Regulation of lens fiber cell differentiation by transcription factor c-Maf. PubMed ID: 10383433

Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development. PubMed ID: 10097114

Regulation of mouse lens fiber cell development and differentiation by the Maf gene. PubMed ID: 10603348

CREB-binding protein/p300 co-activation of crystallin gene expression. PubMed ID: 11943779

Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development. PubMed ID: 14512017

Developmental contribution of c-maf in the kidney: distribution and developmental study of c-maf mRNA in normal mice kidney and histological study of c-maf knockout mice kidney and liver. PubMed ID: 15249232

c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells. PubMed ID: 17823980

CD13/APN transcription is regulated by the proto-oncogene c-Maf via an atypical response element. PubMed ID: 17897790

Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression. PubMed ID: 17901057

A new MAFia in cancer. PubMed ID: 19143053