Genular: Defining Cellular Identity and Function

Details for: Mapkapk2

Gene ID: 17164

Symbol: Mapkapk2

Ensembl ID: ENSMUSG00000016528

Description: MAP kinase-activated protein kinase 2

Associated with

Activated tak1 mediates p38 mapk activation
(R-MMU-450302)
Arachidonic acid metabolism
(R-MMU-2142753)
Butyrate response factor 1 (brf1) binds and destabilizes mrna
(R-MMU-450385)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Cellular senescence
(R-MMU-2559583)
Creb phosphorylation
(R-MMU-199920)
Cytokine signaling in immune system
(R-MMU-1280215)
Death receptor signaling
(R-MMU-73887)
Fatty acid metabolism
(R-MMU-8978868)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-17 signaling
(R-MMU-448424)
Map kinase activation
(R-MMU-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-MMU-450282)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of rna
(R-MMU-8953854)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Nuclear events (kinase and transcription factor activation)
(R-MMU-198725)
Oxidative stress induced senescence
(R-MMU-2559580)
P38mapk events
(R-MMU-171007)
Regulation of hsf1-mediated heat shock response
(R-MMU-3371453)
Regulation of mrna stability by proteins that bind au-rich elements
(R-MMU-450531)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Signaling by interleukins
(R-MMU-449147)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by vegf
(R-MMU-194138)
Signalling to erks
(R-MMU-187687)
Signalling to ras
(R-MMU-167044)
Signal transduction
(R-MMU-162582)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-MMU-2142691)
Tnf signaling
(R-MMU-75893)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Tristetraprolin (ttp, zfp36) binds and destabilizes mrna
(R-MMU-450513)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
3'-utr-mediated mrna stabilization
(GO:0070935)
Atp binding
(GO:0005524)
Calcium-dependent protein serine/threonine kinase activity
(GO:0009931)
Calmodulin-dependent protein kinase activity
(GO:0004683)
Calmodulin binding
(GO:0005516)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Dna damage response
(GO:0006974)
Inflammatory response
(GO:0006954)
Inner ear development
(GO:0048839)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Macrophage cytokine production
(GO:0010934)
Macropinocytosis
(GO:0044351)
Mitogen-activated protein kinase binding
(GO:0051019)
Mrna stabilization
(GO:0048255)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
P38mapk cascade
(GO:0038066)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphorylation
(GO:0016310)
Positive regulation of macrophage cytokine production
(GO:0060907)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of interleukin-6 production
(GO:0032675)
Regulation of tumor necrosis factor production
(GO:0032680)
Response to cytokine
(GO:0034097)
Response to lipopolysaccharide
(GO:0032496)
Toll-like receptor signaling pathway
(GO:0002224)
Transferase activity
(GO:0016740)
Tumor necrosis factor production
(GO:0032640)
Vascular endothelial growth factor receptor signaling pathway
(GO:0048010)

Other Information

Proteins

MAP kinase-activated protein kinase 2

Genular Protein ID: 341061082

Symbol: MAPK2_MOUSE

Name: MAP kinase-activated protein kinase 2

UniProtKB Accession Codes:

P49138 Q6P561

Database IDs:

Citations:

PubMed ID: 8262198

Title: The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain.

PubMed ID: 8262198

DOI: 10.1016/0014-5793(93)81628-d

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8093612

Title: Small heat shock proteins are molecular chaperones.

PubMed ID: 8093612

DOI: 10.1016/s0021-9258(18)53882-5

PubMed ID: 7592979

Title: Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.

PubMed ID: 7592979

DOI: 10.1074/jbc.270.45.27213

PubMed ID: 10559880

Title: MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis.

PubMed ID: 10559880

DOI: 10.1038/10061

PubMed ID: 9628873

Title: Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation.

PubMed ID: 9628873

DOI: 10.1093/emboj/17.12.3363

PubMed ID: 12456657

Title: Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.

PubMed ID: 12456657

DOI: 10.1093/emboj/cdf639

PubMed ID: 12052889

Title: Distinct cellular functions of MK2.

PubMed ID: 12052889

DOI: 10.1128/mcb.22.13.4827-4835.2002

PubMed ID: 14688255

Title: MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding.

PubMed ID: 14688255

DOI: 10.1074/jbc.m310486200

PubMed ID: 15850461

Title: The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.

PubMed ID: 15850461

DOI: 10.1042/bj20050387

PubMed ID: 17030606

Title: The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

PubMed ID: 17030606

DOI: 10.1128/mcb.01456-06

PubMed ID: 17906627

Title: The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways.

PubMed ID: 17906627

DOI: 10.1038/ni1517

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20724476

Title: p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.

PubMed ID: 20724476

DOI: 10.1074/jbc.m110.132357

PubMed ID: 21323643

Title: Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.

PubMed ID: 21323643

DOI: 10.1042/bj20101184

Sequence Information:

Length: 386
Mass: 44050
Checksum: ED7827641A826BF3
Sequence:

MLSGSPGQTP PAPFPSPPPP APAQPPPPFP QFHVKSGLQI RKNAITDDYK VTSQVLGLGI 
NGKVLRIFDK RTQQKFALKM LQDCPKARRE VELHWRASQC PHIVHIVDVY ENLYAGRKCL 
LIVMECLDGG ELFSRIQDRG DQAFTEREAS EIMKSIGEAI QYLHSINIAH RDVKPENLLY 
TSKRPNAILK LTDFGFAKET TSHNSLTTPC YTPYYVAPEV LGPEKYDKSC DMWSLGVIMY 
ILLCGYPPFY SNHGLAISPG MKTRIRMGQY EFPNPEWSEV SEEVKMLIRN LLKTEPTQRM 
TITEFMNHPW IMQSTKVPQT PLHTSRVLKE DKERWEDVKE EMTSALATMR VDYEQIKIKK 
IEDASNPLLL KRRKKARAVE DAALAH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mapkapk2

Associated with

Other Information

The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain. PubMed ID: 8262198

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Small heat shock proteins are molecular chaperones. PubMed ID: 8093612

Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif. PubMed ID: 7592979

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. PubMed ID: 10559880

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation. PubMed ID: 9628873

Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. PubMed ID: 12456657

Distinct cellular functions of MK2. PubMed ID: 12052889

MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. PubMed ID: 14688255

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. PubMed ID: 15850461

The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. PubMed ID: 17030606

The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. PubMed ID: 17906627

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins. PubMed ID: 20724476

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation. PubMed ID: 21323643