Details for: Mapkapk5
Associated with
Other Information
Genular Protein ID: 1586872421
Symbol: MAPK5_MOUSE
Name: MAP kinase-activated protein kinase 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9480836
Title: MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase.
PubMed ID: 9480836
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14560018
Title: Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.
PubMed ID: 14560018
PubMed ID: 15538386
Title: Scaffolding by ERK3 regulates MK5 in development.
PubMed ID: 15538386
PubMed ID: 15577943
Title: Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway.
PubMed ID: 15577943
PubMed ID: 16973613
Title: Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5.
PubMed ID: 16973613
PubMed ID: 17997833
Title: Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity.
PubMed ID: 17997833
PubMed ID: 17254968
Title: PRAK is essential for ras-induced senescence and tumor suppression.
PubMed ID: 17254968
PubMed ID: 17947239
Title: Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5.
PubMed ID: 17947239
PubMed ID: 18248330
Title: The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5.
PubMed ID: 18248330
DOI: 10.1042/bj20071369
PubMed ID: 18268017
Title: Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes.
PubMed ID: 18268017
PubMed ID: 18720373
Title: Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5.
PubMed ID: 18720373
DOI: 10.1002/jcp.21560
PubMed ID: 19473979
Title: Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif.
PubMed ID: 19473979
PubMed ID: 20640477
Title: The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor.
PubMed ID: 20640477
PubMed ID: 20734105
Title: Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function.
PubMed ID: 20734105
PubMed ID: 21575178
Title: Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation.
PubMed ID: 21575178
PubMed ID: 21336308
Title: Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.
PubMed ID: 21336308
DOI: 10.1038/ncb2168
Sequence Information:
- Length: 473
- Mass: 54152
- Checksum: 45441A735075B247
- Sequence:
MSEDSDMEKA IKETSILEEY SINWTQKLGA GISGPVRVCV KKSTQERFAL KILLDRPKAR NEVRLHMMCA THPNIVQIIE VFANSVQFPH ESSPRARLLI VMEMMEGGEL FHRISQHRHF TEKQASQVTK QIALALQHCH LLNIAHRDLK PENLLFKDNS LDAPVKLCDF GFAKVDQGDL MTPQFTPYYV APQVLEAQRR HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP FYSKHHSRTI PKDMRKKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK PLHSVNNPIL RKRKLLGTKP KDGIYIHDHE NGTEDSNVAL EKLRDVIAQC ILPQAGKGEN EDEKLNEVMQ EAWKYNRECK LLRDALQSFS WNGRGFTDKV DRLKLAEVVK QVIEEQTLPH EPQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.