Genular: Defining Cellular Identity and Function

Details for: Ascl1

Gene ID: 17172

Symbol: Ascl1

Ensembl ID: ENSMUSG00000020052

Description: achaete-scute family bHLH transcription factor 1

Associated with

Adrenal chromaffin cell differentiation
(GO:0061104)
Bhlh transcription factor binding
(GO:0043425)
Carotid body glomus cell differentiation
(GO:0061103)
Cell differentiation
(GO:0030154)
Cell maturation
(GO:0048469)
Central nervous system neuron development
(GO:0021954)
Cerebral cortex development
(GO:0021987)
Chromatin binding
(GO:0003682)
Commitment of neuronal cell to specific neuron type in forebrain
(GO:0021902)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
E-box binding
(GO:0070888)
Enteric nervous system development
(GO:0048484)
Forebrain neuron differentiation
(GO:0021879)
Gabaergic neuron differentiation
(GO:0097154)
Generation of neurons
(GO:0048699)
Identical protein binding
(GO:0042802)
Lung neuroendocrine cell differentiation
(GO:0061100)
Motor neuron migration
(GO:0097475)
Multicellular organism development
(GO:0007275)
Musculoskeletal movement, spinal reflex action
(GO:0050883)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neural precursor cell proliferation
(GO:0061351)
Neuroblast fate determination
(GO:0007400)
Neuroblast proliferation
(GO:0007405)
Neuroendocrine cell differentiation
(GO:0061101)
Neurogenesis
(GO:0022008)
Neuron development
(GO:0048666)
Neuron differentiation
(GO:0030182)
Neuron fate commitment
(GO:0048663)
Neuron fate specification
(GO:0048665)
Noradrenergic neuron development
(GO:0003358)
Noradrenergic neuron fate commitment
(GO:0003359)
Notch signaling pathway
(GO:0007219)
Nucleic acid binding
(GO:0003676)
Nucleus
(GO:0005634)
Olfactory pit development
(GO:0060166)
Oligodendrocyte cell fate commitment
(GO:0021779)
Oligodendrocyte development
(GO:0014003)
Oligodendrocyte differentiation
(GO:0048709)
Parasympathetic nervous system development
(GO:0048486)
Pattern specification process
(GO:0007389)
Peripheral nervous system neuron development
(GO:0048935)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of neural precursor cell proliferation
(GO:2000179)
Positive regulation of neurogenesis
(GO:0050769)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of notch signaling pathway
(GO:0045747)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of cell population proliferation
(GO:0042127)
Regulation of epithelial cell differentiation
(GO:0030856)
Regulation of gene expression
(GO:0010468)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of neurogenesis
(GO:0050767)
Regulation of notch signaling pathway
(GO:0008593)
Regulation of timing of subpallium neuron differentiation
(GO:0060165)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sensory organ development
(GO:0007423)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Spinal cord association neuron differentiation
(GO:0021527)
Spinal cord oligodendrocyte cell differentiation
(GO:0021529)
Spinal cord oligodendrocyte cell fate specification
(GO:0021530)
Stomach neuroendocrine cell differentiation
(GO:0061102)
Subpallium neuron fate commitment
(GO:0060163)
Sympathetic ganglion development
(GO:0061549)
Sympathetic nervous system development
(GO:0048485)
Ventral spinal cord interneuron fate commitment
(GO:0060579)
Vestibular nucleus development
(GO:0021750)

Other Information

Proteins

ASCL1_MOUSE

Genular Protein ID: 1649386401

Symbol: ASCL1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q02067 Q7TNT5

Database IDs:

Citations:

PubMed ID: 8424959

Title: Cloning, sequencing and expression of the mouse mammalian achaete-scute homolog 1 (MASH1).

PubMed ID: 8424959

DOI: 10.1016/0167-4781(93)90076-p

PubMed ID: 8217843

Title: Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system.

PubMed ID: 8217843

DOI: 10.1016/0925-4773(93)90006-j

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1576967

Title: Induction and repression of mammalian achaete-scute homologue (MASH) gene expression during neuronal differentiation of P19 embryonal carcinoma cells.

PubMed ID: 1576967

DOI: 10.1242/dev.114.1.75

PubMed ID: 8221886

Title: Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons.

PubMed ID: 8221886

DOI: 10.1016/0092-8674(93)90381-y

PubMed ID: 16020526

Title: Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord.

PubMed ID: 16020526

DOI: 10.1073/pnas.0504799102

PubMed ID: 17728344

Title: A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.

PubMed ID: 17728344

DOI: 10.1242/dev.005868

PubMed ID: 18173746

Title: Mash1 is required for neuroendocrine cell development in the glandular stomach.

PubMed ID: 18173746

DOI: 10.1111/j.1365-2443.2007.01146.x

PubMed ID: 20107439

Title: Direct conversion of fibroblasts to functional neurons by defined factors.

PubMed ID: 20107439

DOI: 10.1038/nature08797

PubMed ID: 24243019

Title: Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.

PubMed ID: 24243019

DOI: 10.1016/j.cell.2013.09.028

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

PubMed ID: 27281220

Title: Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq.

PubMed ID: 27281220

DOI: 10.1038/nature18323

Sequence Information:

Length: 231
Mass: 24741
Checksum: 454E6937520BD4CA
Sequence:

MESSGKMESG AGQQPQPPQP FLPPAACFFA TAAAAAAAAA AAAQSAQQQQ PQAPPQQAPQ 
LSPVADSQPS GGGHKSAAKQ VKRQRSSSPE LMRCKRRLNF SGFGYSLPQQ QPAAVARRNE 
RERNRVKLVN LGFATLREHV PNGAANKKMS KVETLRSAVE YIRALQQLLD EHDAVSAAFQ 
AGVLSPTISP NYSNDLNSMA GSPVSSYSSD EGSYDPLSPE EQELLDFTNW F

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ascl1

Associated with

Other Information

Cloning, sequencing and expression of the mouse mammalian achaete-scute homolog 1 (MASH1). PubMed ID: 8424959

Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system. PubMed ID: 8217843

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Induction and repression of mammalian achaete-scute homologue (MASH) gene expression during neuronal differentiation of P19 embryonal carcinoma cells. PubMed ID: 1576967

Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. PubMed ID: 8221886

Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord. PubMed ID: 16020526

A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool. PubMed ID: 17728344

Mash1 is required for neuroendocrine cell development in the glandular stomach. PubMed ID: 18173746

Direct conversion of fibroblasts to functional neurons by defined factors. PubMed ID: 20107439

Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. PubMed ID: 24243019

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753

Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq. PubMed ID: 27281220