Details for: Ascl2

Gene ID: 17173

Symbol: Ascl2

Ensembl ID: ENSMUSG00000009248

Description: achaete-scute family bHLH transcription factor 2

Associated with

  • Bhlh transcription factor binding
    (GO:0043425)
  • Cell differentiation
    (GO:0030154)
  • Chorionic trophoblast cell development
    (GO:0060719)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • E-box binding
    (GO:0070888)
  • In utero embryonic development
    (GO:0001701)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of schwann cell proliferation
    (GO:0010626)
  • Negative regulation of t-helper 1 cell differentiation
    (GO:0045626)
  • Negative regulation of t-helper 2 cell differentiation
    (GO:0045629)
  • Negative regulation of t-helper 17 cell differentiation
    (GO:2000320)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nervous system development
    (GO:0007399)
  • Neuron differentiation
    (GO:0030182)
  • Nucleus
    (GO:0005634)
  • Placenta development
    (GO:0001890)
  • Positive regulation of t cell migration
    (GO:2000406)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of neurogenesis
    (GO:0050767)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sensory organ development
    (GO:0007423)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Spongiotrophoblast differentiation
    (GO:0060708)
  • Stem cell population maintenance
    (GO:0019827)
  • T follicular helper cell differentiation
    (GO:0061470)

Other Information

Genular Protein ID: 3257489223

Symbol: ASCL2_MOUSE

Name: Achaete-scute homolog 2

UniProtKB Accession Codes:

O35885 Q9WUJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 34 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 2 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 9175731

Title: The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts.

PubMed ID: 9175731

DOI: 10.1093/hmg/6.6.859

PubMed ID: 10495277

Title: Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation.

PubMed ID: 10495277

DOI: 10.1016/s0925-4773(99)00158-6

PubMed ID: 10915772

Title: Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse.

PubMed ID: 10915772

DOI: 10.1093/hmg/9.12.1829

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7773285

Title: Genomic imprinting of Mash2, a mouse gene required for trophoblast development.

PubMed ID: 7773285

DOI: 10.1038/ng0395-235

PubMed ID: 8090202

Title: Essential role of Mash-2 in extraembryonic development.

PubMed ID: 8090202

DOI: 10.1038/371333a0

PubMed ID: 9622625

Title: Mash2 is expressed in oogenesis and preimplantation development but is not required for blastocyst formation.

PubMed ID: 9622625

DOI: 10.1016/s0925-4773(98)00051-3

PubMed ID: 10611232

Title: The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms.

PubMed ID: 10611232

DOI: 10.1128/mcb.20.2.530-541.2000

PubMed ID: 24463518

Title: Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.

PubMed ID: 24463518

DOI: 10.1038/nature12910

PubMed ID: 25620640

Title: Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.

PubMed ID: 25620640

DOI: 10.1016/j.stem.2014.12.006

PubMed ID: 29500235

Title: Intrinsic DNA binding properties demonstrated for lineage-specifying basic helix-loop-helix transcription factors.

PubMed ID: 29500235

DOI: 10.1101/gr.224360.117

Sequence Information:

  • Length: 263
  • Mass: 27784
  • Checksum: 9FA907B436E1BA2E
  • Sequence:
    • MEAHLDWYGV PGLQEASDAC PRESCSSALP EAREGANVHF PPHPVPREHF SCAAPELVAG 
AQGLNASLMD GGALPRLMPT SSGVAGACAA RRRQASPELL RCSRRRRSGA TEASSSSAAV 
ARRNERERNR VKLVNLGFQA LRQHVPHGGA NKKLSKVETL RSAVEYIRAL QRLLAEHDAV 
RAALAGGLLT PATPPSDECA QPSASPASAS LSCASTSPSP DRLGCSEPTS PRSAYSSEES 
SCEGELSPME QELLDFSSWL GGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.