Genular: Defining Cellular Identity and Function

Details for: Mbd3

Gene ID: 17192

Symbol: Mbd3

Ensembl ID: ENSMUSG00000035478

Description: methyl-CpG binding domain protein 3

Associated with

Chromatin modifying enzymes
(R-MMU-3247509)
Chromatin organization
(R-MMU-4839726)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdacs deacetylate histones
(R-MMU-3214815)
Intracellular signaling by second messengers
(R-MMU-9006925)
Pip3 activates akt signaling
(R-MMU-1257604)
Pten regulation
(R-MMU-6807070)
Regulation of pten gene transcription
(R-MMU-8943724)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through acetylation
(R-MMU-6804758)
Rna polymerase ii transcription
(R-MMU-73857)
Rna polymerase i promoter clearance
(R-MMU-73854)
Rna polymerase i transcription
(R-MMU-73864)
Rna polymerase i transcription initiation
(R-MMU-73762)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by tp53
(R-MMU-3700989)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Chromosome
(GO:0005694)
Cytoplasm
(GO:0005737)
Dna binding
(GO:0003677)
Dna methylation-dependent heterochromatin formation
(GO:0006346)
Heterochromatin
(GO:0000792)
In utero embryonic development
(GO:0001701)
Methyl-cpg binding
(GO:0008327)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Nurd complex
(GO:0016581)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of cell fate specification
(GO:0042659)
Regulation of stem cell differentiation
(GO:2000736)
Tissue development
(GO:0009888)

Other Information

Proteins

Methyl-CpG-binding domain protein 3

Genular Protein ID: 3171380348

Symbol: MBD3_MOUSE

Name: Methyl-CpG-binding domain protein 3

UniProtKB Accession Codes:

Q9Z2D8 Q792D3 Q8CFJ1

Database IDs:

Citations:

PubMed ID: 9774669

Title: Identification and characterization of a family of mammalian methyl-CpG binding proteins.

PubMed ID: 9774669

DOI: 10.1128/mcb.18.11.6538

PubMed ID: 10441743

Title: Genomic structure and chromosomal mapping of the murine and human mbd1, mbd2, mbd3, and mbd4 genes.

PubMed ID: 10441743

DOI: 10.1007/s003359901112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14610093

Title: Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression.

PubMed ID: 14610093

DOI: 10.1074/jbc.m309393200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 30228260

Title: A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.

PubMed ID: 30228260

DOI: 10.1038/s41467-018-06235-9

PubMed ID: 30327463

Title: PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.

PubMed ID: 30327463

DOI: 10.1038/s41467-018-06665-5

Sequence Information:

Length: 285
Mass: 32168
Checksum: E4E57BD48463643F
Sequence:

MERKRWECPA LPQGWEREEV PRRSGLSAGH RDVFYYSPSG KKFRSKPQLA RYLGGSMDLS 
TFDFRTGKML MNKMNKSRQR VRYDSSNQVK GKPDLNTALP VRQTASIFKQ PVTKITNHPS 
NKVKSDPQKA VDQPRQLFWE KKLSGLSAFD IAEELVRTMD LPKGLQGVGP GCTDETLLSA 
IASALHTSTL PITGQLSAAV EKNPGVWLNT AQPLCKAFMV TDDDIRKQEE LVQQVRKRLE 
EALMADMLAH VEELARDGEA PLDKACAEEE EEEEEEEEEP EPERV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mbd3

Associated with

Other Information

Identification and characterization of a family of mammalian methyl-CpG binding proteins. PubMed ID: 9774669

Genomic structure and chromosomal mapping of the murine and human mbd1, mbd2, mbd3, and mbd4 genes. PubMed ID: 10441743

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression. PubMed ID: 14610093

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes. PubMed ID: 30228260

PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex. PubMed ID: 30327463