Genular: Defining Cellular Identity and Function

Details for: Mcl1

Gene ID: 17210

Symbol: Mcl1

Ensembl ID: ENSMUSG00000038612

Description: myeloid cell leukemia sequence 1

Associated with

Apoptotic process
(GO:0006915)
Bcl-2 family protein complex
(GO:0097136)
Bh3 domain binding
(GO:0051434)
Bh domain binding
(GO:0051400)
Cell differentiation
(GO:0030154)
Channel activity
(GO:0015267)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Membrane
(GO:0016020)
Mitochondrial fusion
(GO:0008053)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Multicellular organism development
(GO:0007275)
Negative regulation of anoikis
(GO:2000811)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
(GO:1903378)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of apoptotic process
(GO:0042981)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to cytokine
(GO:0034097)

Other Information

Proteins

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

Genular Protein ID: 3472689175

Symbol: MCL1_MOUSE

Name: Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

UniProtKB Accession Codes:

P97287 D2K6L9 Q3TUS0 Q792P0 Q9CRI4

Database IDs:

Citations:

PubMed ID: 9655929

Title: Up-regulated expression of murine Mcl1/EAT, a bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells.

PubMed ID: 9655929

DOI: 10.1016/s0167-4781(98)00059-1

PubMed ID: 19919825

Title: MCL-1V, a novel mouse antiapoptotic MCL-1 variant, generated by RNA splicing at a non-canonical splicing pair.

PubMed ID: 19919825

DOI: 10.1016/j.bbrc.2009.11.086

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9671497

Title: Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response.

PubMed ID: 9671497

DOI: 10.1128/mcb.18.8.4883

PubMed ID: 16543145

Title: Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.

PubMed ID: 16543145

DOI: 10.1016/j.molcel.2006.02.009

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21546903

Title: Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins.

PubMed ID: 21546903

DOI: 10.1038/cdd.2011.47

PubMed ID: 21502331

Title: Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells.

PubMed ID: 21502331

DOI: 10.1084/jem.20101192

PubMed ID: 27013495

Title: The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.

PubMed ID: 27013495

DOI: 10.15252/embr.201541392

PubMed ID: 15550399

Title: Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

PubMed ID: 15550399

DOI: 10.1074/jbc.m411434200

PubMed ID: 18589438

Title: Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1.

PubMed ID: 18589438

DOI: 10.1016/j.jmb.2008.05.071

Sequence Information:

Length: 331
Mass: 35217
Checksum: E4FD369DB0EC6723
Sequence:

MFGLRRNAVI GLNLYCGGAS LGAGGGSPAG ARLVAEEAKA RREGGGEAAL LPGARVVARP 
PPVGAEDPDV TASAERRLHK SPGLLAVPPE EMAASAAAAI VSPEEELDGC EPEAIGKRPA 
VLPLLERVSE AAKSSGADGS LPSTPPPPEE EEDDLYRQSL EIISRYLREQ ATGSKDSKPL 
GEAGAAGRRA LETLRRVGDG VQRNHETAFQ GMLRKLDIKN EGDVKSFSRV MVHVFKDGVT 
NWGRIVTLIS FGAFVAKHLK SVNQESFIEP LAETITDVLV RTKRDWLVKQ RGWDGFVEFF 
HVQDLEGGIR NVLLAFAGVA GVGAGLAYLI R

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mcl1

Associated with

Other Information

Up-regulated expression of murine Mcl1/EAT, a bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells. PubMed ID: 9655929

MCL-1V, a novel mouse antiapoptotic MCL-1 variant, generated by RNA splicing at a non-canonical splicing pair. PubMed ID: 19919825

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. PubMed ID: 9671497

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. PubMed ID: 16543145

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. PubMed ID: 21546903

Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. PubMed ID: 21502331

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. PubMed ID: 27013495

Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. PubMed ID: 15550399

Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1. PubMed ID: 18589438