Genular: Defining Cellular Identity and Function

Details for: Mcm2

Gene ID: 17216

Symbol: Mcm2

Ensembl ID: ENSMUSG00000002870

Description: minichromosome maintenance complex component 2

Associated with

Activation of atr in response to replication stress
(R-MMU-176187)
Activation of the pre-replicative complex
(R-MMU-68962)
Assembly of the pre-replicative complex
(R-MMU-68867)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Dna replication pre-initiation
(R-MMU-69002)
G1/s transition
(R-MMU-69206)
G2/m checkpoints
(R-MMU-69481)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Orc1 removal from chromatin
(R-MMU-68949)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
3'-5' dna helicase activity
(GO:0043138)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Cellular response to interleukin-4
(GO:0071353)
Chromatin
(GO:0000785)
Chromosome
(GO:0005694)
Cmg complex
(GO:0071162)
Cochlea development
(GO:0090102)
Cytoplasm
(GO:0005737)
Dna binding
(GO:0003677)
Dna duplex unwinding
(GO:0032508)
Dna replication
(GO:0006260)
Dna replication initiation
(GO:0006270)
Dna replication origin binding
(GO:0003688)
Dna unwinding involved in dna replication
(GO:0006268)
Double-strand break repair via break-induced replication
(GO:0000727)
Enzyme binding
(GO:0019899)
Helicase activity
(GO:0004386)
Histone binding
(GO:0042393)
Hydrolase activity
(GO:0016787)
Mcm complex
(GO:0042555)
Metal ion binding
(GO:0046872)
Mitotic dna replication initiation
(GO:1902975)
Negative regulation of dna helicase activity
(GO:1905775)
Nuclear origin of replication recognition complex
(GO:0005664)
Nucleoplasm
(GO:0005654)
Nucleosome assembly
(GO:0006334)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Premeiotic dna replication
(GO:0006279)
Single-stranded dna binding
(GO:0003697)
Single-stranded dna helicase activity
(GO:0017116)

Other Information

Proteins

DNA replication licensing factor MCM2

Genular Protein ID: 2332559829

Symbol: MCM2_MOUSE

Name: DNA replication licensing factor MCM2

UniProtKB Accession Codes:

P97310 O08971 O89057 Q8C2R0

Database IDs:

Citations:

PubMed ID: 9077461

Title: Mouse MCM proteins: complex formation and transportation to the nucleus.

PubMed ID: 9077461

DOI: 10.1046/j.1365-2443.1996.840284.x

PubMed ID: 9371513

Title: Clone 10d/BM28 (CDCL1), an early S-phase protein, is an important growth regulator of melanoma.

PubMed ID: 9371513

PubMed ID: 14621295

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 14621295

DOI: 10.1093/dnares/10.4.167

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9798653

Title: Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis.

PubMed ID: 9798653

DOI: 10.1016/s0161-5890(98)00031-5

PubMed ID: 10567526

Title: Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity.

PubMed ID: 10567526

DOI: 10.1128/mcb.19.12.8003

PubMed ID: 10517317

Title: Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes.

PubMed ID: 10517317

DOI: 10.1007/s004380051078

PubMed ID: 11278932

Title: Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1.

PubMed ID: 11278932

DOI: 10.1074/jbc.m011556200

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 17622165

Title: A differential phosphoproteomic analysis of retinoic acid-treated P19 cells.

PubMed ID: 17622165

DOI: 10.1021/pr070122r

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 904
Mass: 102078
Checksum: 7B61C13DAD1CAC58
Sequence:

MAESSESLSA SSPARQRRRI SDPLTSSPGR SSRRADALTS SPGRDLPPFE DESEGLLGTE 
GPMEEEEDGE ELIGDGMERD YRPIPELDVY EAEGLALDDE DVEELTASQR EAAERTMRQR 
DREAGRGLGR MRRGLLYDSS EEDEERPARK RRHVERATED GEEDEEMIES IENLEDLKGH 
SVREWVSMAG PRLEIHHRFK NFLRTHVDSH GHNVFKERIS DMCKENRESL VVNYEDLAAR 
EHVLAYFLPE APAELLQIFD EAALEVVLAM YPKYDRITNH IHVRISHLPL VEELRSLRQL 
HLNQLIRTSG VVTSCTGVLP QLSMVKYNCS KCNFVLGPFC QSQNQEVKPG SCPECQSAGP 
FEINMEETIY QNYQRIRIQE SPGKVAAGRL PRSKDAILLA DLVDSCKPGD EIELTGIYHN 
NYDGSLNTAN GFPVFATIIL ANHVAKKDNK VAVGELTDED VKMITGLSKD QQIGEKIFAS 
IAPSIYGHED IKRGLALALF GGEPKNPGGK HKVRGDINVL LCGDPGTAKS QFLKYIEKVS 
SRAIFTTGQG ASAVGLTAYV QRHPVSREWT LEAGALVLAD RGVCLIDEFD KMNDQDRTSI 
HEAMEQQSIS ISKAGIVTSL QARCTVIAAA NPIGGRYDPS LTFSENVDLT EPIISRFDVL 
CVVRDTVDPV QDEMLARFVV GSHVRHHPSN KKDEGLTNGG TLEPAMPNTY GVEPLPQEVL 
KKYIIYAKER VRPKLNQMDQ DKVARMYSDL RKESMATGSI PITVRHIESM IRMAEAHARM 
HLRDYVMEDD VNMAIRVMME SFIDTQKFSV MRSMRKTFAR YLSFRRDNND LLLFILKQLV 
AEQVTYQRNR FGAQQDTIEI PEKDLMDKAR QINIHNLSAF YDSDLFKFNK FSRDLKRKLI 
LQQF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mcm2

Associated with

Other Information

Mouse MCM proteins: complex formation and transportation to the nucleus. PubMed ID: 9077461

Clone 10d/BM28 (CDCL1), an early S-phase protein, is an important growth regulator of melanoma. PubMed ID: 9371513

Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 14621295

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. PubMed ID: 9798653

Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity. PubMed ID: 10567526

Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes. PubMed ID: 10517317

Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1. PubMed ID: 11278932

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

A differential phosphoproteomic analysis of retinoic acid-treated P19 cells. PubMed ID: 17622165

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079