Genular: Defining Cellular Identity and Function

Details for: Cd46

Gene ID: 17221

Symbol: Cd46

Ensembl ID: ENSMUSG00000016493

Description: CD46 antigen, complement regulatory protein

Associated with

Complement cascade
(R-MMU-166658)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Regulation of complement cascade
(R-MMU-977606)
Acrosomal vesicle
(GO:0001669)
Basolateral plasma membrane
(GO:0016323)
Cadherin binding
(GO:0045296)
Cell surface
(GO:0009986)
Cytoplasmic vesicle
(GO:0031410)
Endopeptidase activity
(GO:0004175)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Inner acrosomal membrane
(GO:0002079)
Membrane
(GO:0016020)
Negative regulation of complement activation, classical pathway
(GO:0045959)
Negative regulation of gene expression
(GO:0010629)
Plasma membrane
(GO:0005886)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of memory t cell differentiation
(GO:0043382)
Positive regulation of proteolysis
(GO:0045862)
Positive regulation of regulatory t cell differentiation
(GO:0045591)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of transforming growth factor beta production
(GO:0071636)
Regulation of notch signaling pathway
(GO:0008593)
Sequestering of extracellular ligand from receptor
(GO:0035581)
Single fertilization
(GO:0007338)
T cell mediated immunity
(GO:0002456)

Other Information

Proteins

Membrane cofactor protein

Genular Protein ID: 3905567733

Symbol: MCP_MOUSE

Name: Membrane cofactor protein

UniProtKB Accession Codes:

O88174 Q9R0R9

Database IDs:

Citations:

PubMed ID: 9461505

Title: Molecular cloning of a murine homologue of membrane cofactor protein (CD46): preferential expression in testicular germ cells.

PubMed ID: 9461505

DOI: 10.1042/bj3300163

PubMed ID: 9799332

Title: Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1.

PubMed ID: 9799332

DOI: 10.1007/s002510050447

PubMed ID: 10630288

Title: Membrane and secretory forms of mouse membrane cofactor protein (CD46) generated from a single gene through alternative splicing.

PubMed ID: 10630288

DOI: 10.1007/s002510050600

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 12640142

Title: Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm.

PubMed ID: 12640142

DOI: 10.1128/mcb.23.7.2614-2622.2003

Sequence Information:

Length: 365
Mass: 40881
Checksum: 84A4CA8EE165C629
Sequence:

MTAAPLMPDS THPCRRRKSY TFFWCSLGVY AEALLFLLSH LSDACELPRP FEAMELKGTP 
KLFYAVGEKI EYKCKKGYLY LSPYLMIATC EPNHTWVPIS DAGCIKVQCT MLQDPSFGKV 
YYIDGSFSWG ARAKFTCMEG YYVVGMSVLH CVLKGDDEAY WNGYPPHCEK IYCLPPPKIK 
NGTHTLTDIN VFKYHEAVSY SCDPTPGPDK FSLVGTSMIF CAGHNTWSNS PPECKVVKCP 
NPVLQNGRLI SGAGEIFSYQ STVMFECLQG FYMEGSSMVI CSANNSWEPS IPKCLKGPRP 
THPTKPPVYN YTGYPSPREG IFSQELDAWI IALIVITSIV GVFILCLIVL RCFEHRKKTN 
VSAAR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd46

Associated with

Other Information

Molecular cloning of a murine homologue of membrane cofactor protein (CD46): preferential expression in testicular germ cells. PubMed ID: 9461505

Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1. PubMed ID: 9799332

Membrane and secretory forms of mouse membrane cofactor protein (CD46) generated from a single gene through alternative splicing. PubMed ID: 10630288