Genular: Defining Cellular Identity and Function

Details for: Cma1

Gene ID: 17228

Symbol: Cma1

Ensembl ID: ENSMUSG00000022225

Description: chymase 1, mast cell

Associated with

Activation of matrix metalloproteinases
(R-MMU-1592389)
Degradation of the extracellular matrix
(R-MMU-1474228)
Extracellular matrix organization
(R-MMU-1474244)
Metabolism of angiotensinogen to angiotensins
(R-MMU-2022377)
Metabolism of proteins
(R-MMU-392499)
Peptide hormone metabolism
(R-MMU-2980736)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by scf-kit
(R-MMU-1433557)
Signal transduction
(R-MMU-162582)
Basement membrane disassembly
(GO:0034769)
Cytokine precursor processing
(GO:0140447)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytosol
(GO:0005829)
Endopeptidase activity
(GO:0004175)
Extracellular matrix disassembly
(GO:0022617)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hydrolase activity
(GO:0016787)
Intracellular anatomical structure
(GO:0005622)
Intracellular membrane-bounded organelle
(GO:0043231)
Peptidase activity
(GO:0008233)
Peptide binding
(GO:0042277)
Positive regulation of angiogenesis
(GO:0045766)
Protein catabolic process
(GO:0030163)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Regulation of inflammatory response
(GO:0050727)
Secretory granule
(GO:0030141)
Serine-type endopeptidase activity
(GO:0004252)
Serine-type peptidase activity
(GO:0008236)

Other Information

Proteins

Chymase
A4QPC5_MOUSE

Genular Protein ID: 2417228168

Symbol: CMA1_MOUSE

Name: Chymase

UniProtKB Accession Codes:

P21844 Q9R1F0

Database IDs:

Citations:

PubMed ID: 1939089

Title: Molecular cloning of the mouse mast cell protease-5 gene. A novel secretory granule protease expressed early in the differentiation of serosal mast cells.

PubMed ID: 1939089

DOI: 10.1016/s0021-9258(18)54925-5

PubMed ID: 2060576

Title: Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases.

PubMed ID: 2060576

DOI: 10.1002/eji.1830210706

PubMed ID: 1376147

Title: Molecular cloning and characterization of mouse mast cell chymases.

PubMed ID: 1376147

DOI: 10.1016/0167-4838(92)90340-j

PubMed ID: 11398967

Title: Characterization of the gene encoding mouse mast cell protease 8 (mMCP-8), and a comparative analysis of hematopoietic serine protease genes.

PubMed ID: 11398967

DOI: 10.1007/s002510100316

PubMed ID: 2326280

Title: Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases.

PubMed ID: 2326280

DOI: 10.1073/pnas.87.8.3230

PubMed ID: 1527387

Title: Translation and granule localization of mouse mast cell protease-5. Immunodetection with specific antipeptide Ig.

PubMed ID: 1527387

Sequence Information:

Length: 247
Mass: 27586
Checksum: 24C290CF61237DC7
Sequence:

MHLLTLHLLL LLLGSSTKAG EIIGGTECIP HSRPYMAYLE IVTSENYLSA CSGFLIRRNF 
VLTAAHCAGR SITVLLGAHN KTSKEDTWQK LEVEKQFLHP KYDENLVVHD IMLLKLKEKA 
KLTLGVGTLP LSANFNFIPP GRMCRAVGWG RTNVNEPASD TLQEVKMRLQ EPQACKHFTS 
FRHNSQLCVG NPKKMQNVYK GDSGGPLLCA GIAQGIASYV HRNAKPPAVF TRISHYRPWI 
NKILREN

Genular Protein ID: 4080904407

Symbol: A4QPC5_MOUSE

Name: N/A

UniProtKB Accession Codes:

A4QPC5

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 260
Mass: 29051
Checksum: 82EE5946794ACC21
Sequence:

MKPAAALRRP SERMHLLTLH LLLLLLGSST KAGEIIGGTE CIPHSRPYMA YLEIVTSENY 
LSACSGFLIR RNFVLTAAHC AGRSITVLLG AHNKTSKEDT WQKLEVEKQF LHPKYDENLV 
VHDIMLLKLK EKAKLTLGVG TLPLSANFNF IPPGRMCRAV GWGRTNVNEP ASDTLQEVKM 
RLQEPQACKH FTSFRHNSQL CVGNPKKMQN VYKGDSGGPL LCAGIAQGIA SYVHRNAKPP 
AVFTRISHYR PWINKILREN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cma1

Associated with

Other Information

Molecular cloning of the mouse mast cell protease-5 gene. A novel secretory granule protease expressed early in the differentiation of serosal mast cells. PubMed ID: 1939089

Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases. PubMed ID: 2060576

Molecular cloning and characterization of mouse mast cell chymases. PubMed ID: 1376147

Characterization of the gene encoding mouse mast cell protease 8 (mMCP-8), and a comparative analysis of hematopoietic serine protease genes. PubMed ID: 11398967

Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. PubMed ID: 2326280

Translation and granule localization of mouse mast cell protease-5. Immunodetection with specific antipeptide Ig. PubMed ID: 1527387

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303