Details for: Mdk

Gene ID: 17242

Symbol: Mdk

Ensembl ID: ENSMUSG00000027239

Description: midkine

Associated with

  • Mdk and ptn in alk signaling
    (R-MMU-9851151)
  • Signaling by alk
    (R-MMU-201556)
  • Signaling by receptor tyrosine kinases
    (R-MMU-9006934)
  • Signal transduction
    (R-MMU-162582)
  • Adrenal gland development
    (GO:0030325)
  • Behavioral fear response
    (GO:0001662)
  • Cell differentiation
    (GO:0030154)
  • Cell migration
    (GO:0016477)
  • Cell projection
    (GO:0042995)
  • Cerebellar granular layer development
    (GO:0021681)
  • Cerebral cortex development
    (GO:0021987)
  • Chondroitin sulfate binding
    (GO:0035374)
  • Cytoskeleton organization
    (GO:0007010)
  • Defecation
    (GO:0030421)
  • Dentate gyrus development
    (GO:0021542)
  • Estrous cycle
    (GO:0044849)
  • Extracellular region
    (GO:0005576)
  • Glial cell projection elongation
    (GO:0106091)
  • Growth factor activity
    (GO:0008083)
  • Heparan sulfate binding
    (GO:1904399)
  • Heparin binding
    (GO:0008201)
  • Hippocampus development
    (GO:0021766)
  • Intracellular signal transduction
    (GO:0035556)
  • Leukocyte chemotaxis involved in inflammatory response
    (GO:0002232)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cardiac muscle cell apoptotic process
    (GO:0010667)
  • Negative regulation of cell adhesion
    (GO:0007162)
  • Negative regulation of epithelial cell apoptotic process
    (GO:1904036)
  • Negative regulation of inflammatory response to wounding
    (GO:0106015)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of ossification
    (GO:0030279)
  • Negative regulation of regulatory t cell differentiation
    (GO:0045590)
  • Oogenesis
    (GO:0048477)
  • Positive regulation of artery morphogenesis
    (GO:1905653)
  • Positive regulation of blood vessel branching
    (GO:1905555)
  • Positive regulation of cartilage development
    (GO:0061036)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of cell division
    (GO:0051781)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of hepatocyte proliferation
    (GO:2000347)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of inflammatory response to wounding
    (GO:0106016)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of keratinocyte proliferation
    (GO:0010838)
  • Positive regulation of leukocyte adhesion to vascular endothelial cell
    (GO:1904996)
  • Positive regulation of leukocyte cell-cell adhesion
    (GO:1903039)
  • Positive regulation of leukocyte chemotaxis
    (GO:0002690)
  • Positive regulation of macrophage chemotaxis
    (GO:0010759)
  • Positive regulation of neural precursor cell proliferation
    (GO:2000179)
  • Positive regulation of neuron migration
    (GO:2001224)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of neutrophil chemotaxis
    (GO:0090023)
  • Positive regulation of neutrophil extravasation
    (GO:2000391)
  • Positive regulation of oligodendrocyte differentiation
    (GO:0048714)
  • Positive regulation of smooth muscle cell chemotaxis
    (GO:0071673)
  • Positive regulation of substrate adhesion-dependent cell spreading
    (GO:1900026)
  • Positive regulation of t cell differentiation
    (GO:0045582)
  • Positive regulation of vascular endothelial cell proliferation
    (GO:1905564)
  • Protein binding
    (GO:0005515)
  • Regulation of behavior
    (GO:0050795)
  • Regulation of bone remodeling
    (GO:0046850)
  • Regulation of chondrocyte differentiation
    (GO:0032330)
  • Response to auditory stimulus
    (GO:0010996)
  • Response to wounding
    (GO:0009611)
  • Short-term memory
    (GO:0007614)
  • T cell activation involved in immune response
    (GO:0002286)
  • Tissue regeneration
    (GO:0042246)

Other Information

Genular Protein ID: 2645968628

Symbol: MK_MOUSE

Name: Retinoic acid-induced differentiation factor

UniProtKB Accession Codes:

P12025

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 6 Ensembl 4 GO 63 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2345177

Title: Structure of a retinoic acid-responsive gene, MK, which is transiently activated during the differentiation of embryonal carcinoma cells and the mid-gestation period of mouse embryogenesis.

PubMed ID: 2345177

DOI: 10.1016/s0021-9258(19)38868-4

PubMed ID: 2355021

Title: A retinoic acid-responsive gene, MK, found in the teratocarcinoma system. Heterogeneity of the transcript and the nature of the translation product.

PubMed ID: 2355021

DOI: 10.1016/s0021-9258(18)87013-2

PubMed ID: 3355557

Title: cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis.

PubMed ID: 3355557

DOI: 10.1016/s0006-291x(88)80505-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8827451

Title: Midkine, a heparin-binding growth/differentiation factor, exhibits nerve cell adhesion and guidance activity for neurite outgrowth in vitro.

PubMed ID: 8827451

DOI: 10.1093/oxfordjournals.jbchem.a021361

PubMed ID: 9089390

Title: Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine.

PubMed ID: 9089390

PubMed ID: 10096022

Title: Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour.

PubMed ID: 10096022

DOI: 10.1046/j.1365-2443.1998.00231.x

PubMed ID: 10212223

Title: A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta.

PubMed ID: 10212223

DOI: 10.1074/jbc.274.18.12474

PubMed ID: 10978312

Title: Neuronal cell adhesion, mediated by the heparin-binding neuroregulatory factor midkine, is specifically inhibited by chondroitin sulfate E. Structural ans functional implications of the over-sulfated chondroitin sulfate.

PubMed ID: 10978312

DOI: 10.1074/jbc.m002538200

PubMed ID: 10683378

Title: Neointima formation in a restenosis model is suppressed in midkine-deficient mice.

PubMed ID: 10683378

DOI: 10.1172/jci7208

PubMed ID: 12084985

Title: Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth.

PubMed ID: 12084985

DOI: 10.1023/a:1016042303253

PubMed ID: 15509530

Title: Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.

PubMed ID: 15509530

DOI: 10.1016/s0002-9440(10)63417-7

PubMed ID: 15482347

Title: The role of midkine and pleiotrophin in liver regeneration.

PubMed ID: 15482347

DOI: 10.1111/j.1478-3231.2004.0990.x

PubMed ID: 17015789

Title: Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction.

PubMed ID: 17015789

DOI: 10.1161/circulationaha.106.632273

PubMed ID: 17121547

Title: Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors.

PubMed ID: 17121547

DOI: 10.1111/j.1365-2443.2006.01028.x

PubMed ID: 16901907

Title: Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells.

PubMed ID: 16901907

DOI: 10.1074/jbc.m602228200

PubMed ID: 17230638

Title: Midkine, a heparin-binding growth factor, is expressed in neural precursor cells and promotes their growth.

PubMed ID: 17230638

DOI: 10.1111/j.1471-4159.2006.04138.x

PubMed ID: 16619002

Title: Mice doubly deficient in the midkine and pleiotrophin genes exhibit deficits in the expression of beta-tectorin gene and in auditory response.

PubMed ID: 16619002

DOI: 10.1038/labinvest.3700428

PubMed ID: 19060126

Title: Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction.

PubMed ID: 19060126

DOI: 10.1152/ajpheart.00733.2008

PubMed ID: 20200993

Title: Increased trabecular bone formation in mice lacking the growth factor midkine.

PubMed ID: 20200993

DOI: 10.1002/jbmr.75

PubMed ID: 21185956

Title: Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading.

PubMed ID: 21185956

DOI: 10.1016/j.bone.2010.12.019

PubMed ID: 22323540

Title: Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells.

PubMed ID: 22323540

DOI: 10.4049/jimmunol.1102346

PubMed ID: 24458438

Title: The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via beta2 integrins (CD11/CD18).

PubMed ID: 24458438

DOI: 10.1182/blood-2013-06-510875

PubMed ID: 25551381

Title: Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice.

PubMed ID: 25551381

DOI: 10.1371/journal.pone.0116282

PubMed ID: 28183532

Title: Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis.

PubMed ID: 28183532

DOI: 10.1016/j.ajpath.2016.12.006

PubMed ID: 29233575

Title: Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3.

PubMed ID: 29233575

DOI: 10.1016/j.ebiom.2017.11.020

Sequence Information:

  • Length: 140
  • Mass: 15434
  • Checksum: DAE31FEC94B29CF7
  • Sequence:
    • MQHRGFFLLA LLALLVVTSA VAKKKEKVKK GSECSEWTWG PCTPSSKDCG MGFREGTCGA 
QTQRVHCKVP CNWKKEFGAD CKYKFESWGA CDGSTGTKAR QGTLKKARYN AQCQETIRVT 
KPCTSKTKSK TKAKKGKGKD

Genular Protein ID: 2563377385

Symbol: Q2LEK5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q2LEK5

Database IDs:

AGR 1 ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 InterPro 5 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1

Sequence Information:

  • Length: 86
  • Mass: 9461
  • Checksum: 4EC63CDDB23FE839
  • Sequence:
    • MQHRGFFLLA LLALLVVTSA VAKKKEKVKK GSECSEWTWG PCTPSSKDCG MGFREGTCGA 
QTQRVHCKVP CNWKKEFGAK KGKGKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.