Genular: Defining Cellular Identity and Function

Details for: Mdm2

Gene ID: 17246

Symbol: Mdm2

Ensembl ID: ENSMUSG00000020184

Description: transformed mouse 3T3 cell double minute 2

Associated with

Akt phosphorylates targets in the cytosol
(R-MMU-198323)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Deubiquitination
(R-MMU-5688426)
G1/s dna damage checkpoints
(R-MMU-69615)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-MMU-399721)
Intracellular signaling by second messengers
(R-MMU-9006925)
Metabolism of proteins
(R-MMU-392499)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Oncogene induced senescence
(R-MMU-2559585)
Oxidative stress induced senescence
(R-MMU-2559580)
P53-dependent g1 dna damage response
(R-MMU-69563)
P53-dependent g1/s dna damage checkpoint
(R-MMU-69580)
Pip3 activates akt signaling
(R-MMU-1257604)
Post-translational protein modification
(R-MMU-597592)
Regulation of runx3 expression and activity
(R-MMU-8941858)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through methylation
(R-MMU-6804760)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Regulation of tp53 degradation
(R-MMU-6804757)
Regulation of tp53 expression and degradation
(R-MMU-6806003)
Rna polymerase ii transcription
(R-MMU-73857)
Signal transduction
(R-MMU-162582)
Stabilization of p53
(R-MMU-69541)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of ubiquitinylation proteins
(R-MMU-3232142)
Trafficking of ampa receptors
(R-MMU-399719)
Transcriptional regulation by runx3
(R-MMU-8878159)
Transcriptional regulation by tp53
(R-MMU-3700989)
Transmission across chemical synapses
(R-MMU-112315)
Ub-specific processing proteases
(R-MMU-5689880)
5s rrna binding
(GO:0008097)
Apoptotic process
(GO:0006915)
Atrial septum development
(GO:0003283)
Atrioventricular valve morphogenesis
(GO:0003181)
Blood vessel development
(GO:0001568)
Blood vessel remodeling
(GO:0001974)
Cell cycle
(GO:0007049)
Disordered domain specific binding
(GO:0097718)
Dna damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
(GO:0006977)
Endocardial cushion morphogenesis
(GO:0003203)
Enzyme binding
(GO:0019899)
Establishment of protein localization
(GO:0045184)
Heart development
(GO:0007507)
Heart valve development
(GO:0003170)
Identical protein binding
(GO:0042802)
Ligase activity
(GO:0016874)
Metal ion binding
(GO:0046872)
Nedd8 ligase activity
(GO:0061663)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of dna damage response, signal transduction by p53 class mediator
(GO:0043518)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of protein processing
(GO:0010955)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
P53 binding
(GO:0002039)
Peroxisome proliferator activated receptor binding
(GO:0042975)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mitotic cell cycle
(GO:0045931)
Positive regulation of muscle cell differentiation
(GO:0051149)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein export from nucleus
(GO:0046827)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein domain specific binding
(GO:0019904)
Protein localization to nucleus
(GO:0034504)
Protein ubiquitination
(GO:0016567)
Proteolysis involved in protein catabolic process
(GO:0051603)
Receptor serine/threonine kinase binding
(GO:0033612)
Regulation of gene expression
(GO:0010468)
Regulation of heart rate
(GO:0002027)
Regulation of protein catabolic process
(GO:0042176)
Ribonucleoprotein complex binding
(GO:0043021)
Sumo transferase activity
(GO:0019789)
Transferase activity
(GO:0016740)
Traversing start control point of mitotic cell cycle
(GO:0007089)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase activity
(GO:0061630)
Ubiquitin protein ligase binding
(GO:0031625)
Ventricular septum development
(GO:0003281)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 ubiquitin-protein ligase Mdm2

Genular Protein ID: 1799322522

Symbol: MDM2_MOUSE

Name: E3 ubiquitin-protein ligase Mdm2

UniProtKB Accession Codes:

P23804 Q61040 Q64330 Q91XK7

Database IDs:

Citations:

PubMed ID: 2026149

Title: Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

PubMed ID: 2026149

DOI: 10.1002/j.1460-2075.1991.tb07676.x

PubMed ID: 8917101

Title: Genomic organization of the mouse double minute 2 gene.

PubMed ID: 8917101

DOI: 10.1016/0378-1119(96)00151-5

PubMed ID: 8660994

Title: The organization and expression of the mdm2 gene.

PubMed ID: 8660994

DOI: 10.1006/geno.1996.0210

PubMed ID: 10075719

Title: Multiple murine double minute gene 2 (MDM2) proteins are induced by ultraviolet light.

PubMed ID: 10075719

DOI: 10.1074/jbc.274.12.8161

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10713175

Title: Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

PubMed ID: 10713175

DOI: 10.1128/mcb.20.7.2517-2528.2000

PubMed ID: 10611322

Title: Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.

PubMed ID: 10611322

DOI: 10.1073/pnas.96.26.14973

PubMed ID: 10906133

Title: A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2.

PubMed ID: 10906133

DOI: 10.1074/jbc.m004252200

PubMed ID: 11588219

Title: Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.

PubMed ID: 11588219

DOI: 10.1126/science.1063866

PubMed ID: 14642282

Title: Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.

PubMed ID: 14642282

DOI: 10.1016/s0896-6273(03)00687-1

PubMed ID: 15195100

Title: PML regulates p53 stability by sequestering Mdm2 to the nucleolus.

PubMed ID: 15195100

DOI: 10.1038/ncb1147

PubMed ID: 17110379

Title: A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.

PubMed ID: 17110379

DOI: 10.1074/jbc.m609612200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21804542

Title: Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.

PubMed ID: 21804542

DOI: 10.1038/nm.2392

PubMed ID: 25088421

Title: Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons.

PubMed ID: 25088421

DOI: 10.1016/j.celrep.2014.06.056

PubMed ID: 25751059

Title: BAI1 regulates spatial learning and synaptic plasticity in the hippocampus.

PubMed ID: 25751059

DOI: 10.1172/jci74603

PubMed ID: 30879903

Title: MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network.

PubMed ID: 30879903

DOI: 10.1016/j.molcel.2019.02.012

Sequence Information:

Length: 489
Mass: 54558
Checksum: 4ABF489A82038DF4
Sequence:

MCNTNMSVST EGAASTSQIP ASEQETLVRP KPLLLKLLKS VGAQNDTYTM KEIIFYIGQY 
IMTKRLYDEK QQHIVYCSND LLGDVFGVPS FSVKEHRKIY AMIYRNLVAV SQQDSGTSLS 
ESRRQPEGGS DLKDPLQAPP EEKPSSSDLI SRLSTSSRRR SISETEENTD ELPGERHRKR 
RRSLSFDPSL GLCELREMCS GGSSSSSSSS SESTETPSHQ DLDDGVSEHS GDCLDQDSVS 
DQFSVEFEVE SLDSEDYSLS DEGHELSDED DEVYRVTVYQ TGESDTDSFE GDPEISLADY 
WKCTSCNEMN PPLPSHCKRC WTLRENWLPD DKGKDKVEIS EKAKLENSAQ AEEGLDVPDG 
KKLTENDAKE PCAEEDSEEK AEQTPLSQES DDYSQPSTSS SIVYSSQESV KELKEETQDK 
DESVESSFSL NAIEPCVICQ GRPKNGCIVH GKTGHLMSCF TCAKKLKKRN KPCPVCRQPI 
QMIVLTYFN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mdm2

Associated with

Other Information

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. PubMed ID: 2026149

Genomic organization of the mouse double minute 2 gene. PubMed ID: 8917101

The organization and expression of the mdm2 gene. PubMed ID: 8660994

Multiple murine double minute gene 2 (MDM2) proteins are induced by ultraviolet light. PubMed ID: 10075719

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. PubMed ID: 10713175

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. PubMed ID: 10611322

A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. PubMed ID: 10906133

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. PubMed ID: 11588219

Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. PubMed ID: 14642282

PML regulates p53 stability by sequestering Mdm2 to the nucleolus. PubMed ID: 15195100

A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. PubMed ID: 17110379

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. PubMed ID: 21804542

Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons. PubMed ID: 25088421

BAI1 regulates spatial learning and synaptic plasticity in the hippocampus. PubMed ID: 25751059

MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network. PubMed ID: 30879903