Genular: Defining Cellular Identity and Function

Details for: Abcc1

Gene ID: 17250

Symbol: Abcc1

Ensembl ID: ENSMUSG00000023088

Description: ATP-binding cassette, sub-family C member 1

Associated with

Abc-family proteins mediated transport
(R-MMU-382556)
Arachidonic acid metabolism
(R-MMU-2142753)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Cobalamin (cbl, vitamin b12) transport and metabolism
(R-MMU-196741)
Cytoprotection by hmox1
(R-MMU-9707564)
Drug adme
(R-MMU-9748784)
Fatty acid metabolism
(R-MMU-8978868)
Heme degradation
(R-MMU-189483)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of porphyrins
(R-MMU-189445)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Metabolism of water-soluble vitamins and cofactors
(R-MMU-196849)
Paracetamol adme
(R-MMU-9753281)
Sphingolipid de novo biosynthesis
(R-MMU-1660661)
Sphingolipid metabolism
(R-MMU-428157)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-MMU-2142691)
Transport of rcbl within the body
(R-MMU-9758890)
Transport of small molecules
(R-MMU-382551)
Abc-type glutathione s-conjugate transporter activity
(GO:0015431)
Abc-type transporter activity
(GO:0140359)
Abc-type vitamin b12 transporter activity
(GO:0015420)
Abc-type xenobiotic transporter activity
(GO:0008559)
Amide transmembrane transporter activity
(GO:0042887)
Apical plasma membrane
(GO:0016324)
Astrocyte differentiation
(GO:0048708)
Atpase-coupled lipid transmembrane transporter activity
(GO:0034040)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Carboxylic acid transmembrane transport
(GO:1905039)
Carboxylic acid transmembrane transporter activity
(GO:0046943)
Cell chemotaxis
(GO:0060326)
Cellular response to amyloid-beta
(GO:1904646)
Cobalamin transport
(GO:0015889)
Cyclic nucleotide transport
(GO:0070729)
Efflux transmembrane transporter activity
(GO:0015562)
Export across plasma membrane
(GO:0140115)
Glial cell differentiation
(GO:0010001)
Glutathione transmembrane transport
(GO:0034775)
Glutathione transmembrane transporter activity
(GO:0034634)
Hydrolase activity
(GO:0016787)
Lateral plasma membrane
(GO:0016328)
Leukotriene transport
(GO:0071716)
Lipid transport
(GO:0006869)
Long-chain fatty acid import across plasma membrane
(GO:0015911)
Long-chain fatty acid transporter activity
(GO:0005324)
Membrane
(GO:0016020)
Nucleotide binding
(GO:0000166)
Phospholipid efflux
(GO:0033700)
Phospholipid translocation
(GO:0045332)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of inflammatory response
(GO:0050729)
Regulation of cellular response to drug
(GO:2001038)
Response to oxidative stress
(GO:0006979)
Response to xenobiotic stimulus
(GO:0009410)
Sphingolipid translocation
(GO:0099039)
Transepithelial transport
(GO:0070633)
Transmembrane transport
(GO:0055085)
Transmembrane transporter activity
(GO:0022857)
Xenobiotic detoxification by transmembrane export across the plasma membrane
(GO:1990961)
Xenobiotic transmembrane transporter activity
(GO:0042910)
Xenobiotic transport
(GO:0042908)
Xenobiotic transport across blood-brain barrier
(GO:1990962)

Other Information

Proteins

ATP-binding cassette sub-family C member 1

Genular Protein ID: 1149581828

Symbol: MRP1_MOUSE

Name: ATP-binding cassette sub-family C member 1

UniProtKB Accession Codes:

O35379

Database IDs:

Citations:

PubMed ID: 8649356

Title: Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter.

PubMed ID: 8649356

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9281595

Title: Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells.

PubMed ID: 9281595

DOI: 10.1124/mol.52.3.344

PubMed ID: 9359705

Title: Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein.

PubMed ID: 9359705

DOI: 10.1038/nm1197-1275

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 36070769

Title: ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP.

PubMed ID: 36070769

DOI: 10.1016/j.immuni.2022.08.006

Sequence Information:

Length: 1528
Mass: 171185
Checksum: 68FD13667D61DBBB
Sequence:

MALRSFCSAD GSDPLWDWNV TWHTSNPDFT KCFQNTVLTW VPCFYLWSCF PLYFFYLSRH 
DRGYIQMTHL NKTKTALGFF LWIICWADLF YSFWERSQGV LRAPVLLVSP TLLGITMLLA 
TFLIQLERRK GVQSSGIMLT FWLVALLCAL AILRSKIISA LKKDAHVDVF RDSTFYLYFT 
LVLVQLVLSC FSDCSPLFSE TVHDRNPCPE SSASFLSRIT FWWITGMMVH GYRQPLESSD 
LWSLNKEDTS EEVVPVLVNN WKKECDKSRK QPVRIVYAPP KDPSKPKGSS QLDVNEEVEA 
LIVKSPHKDR EPSLFKVLYK TFGPYFLMSF LYKALHDLMM FAGPKILELI INFVNDREAP 
DWQGYFYTAL LFVSACLQTL ALHQYFHICF VSGMRIKTAV VGAVYRKALL ITNAARKSST 
VGEIVNLMSV DAQRFMDLAT YINMIWSAPL QVILALYFLW LSLGPSVLAG VAVMILMVPL 
NAVMAMKTKT YQVAHMKSKD NRIKLMNEIL NGIKVLKLYA WELAFQDKVM SIRQEELKVL 
KKSAYLAAVG TFTWVCTPFL VALSTFAVFV TVDERNILDA KKAFVSLALF NILRFPLNIL 
PMVISSIVQA SVSLKRLRIF LSHEELEPDS IERRSIKSGE GNSITVKNAT FTWARGEPPT 
LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG HVTLKGSVAY VPQQAWIQND 
SLRENILFGH PLQENYYKAV MEACALLPDL EILPSGDRTE IGEKGVNLSG GQKQRVSLAR 
AVYSNSDIYL FDDPLSAVDA HVGKHIFEKV VGPMGLLKNK TRILVTHGIS YLPQVDVIIV 
MSGGKISEMG SYQELLDRDG AFAEFLRTYA NAEQDLASED DSVSGSGKES KPVENGMLVT 
DTVGKHLQRH LSNSSSHSGD TSQQHSSIAE LQKAGAKEET WKLMEADKAQ TGQVQLSVYW 
NYMKAIGLFI TFLSIFLFLC NHVSALASNY WLSLWTDDPP VVNGTQANRN FRLSVYGALG 
ILQGAAIFGY SMAVSIGGIF ASRRLHLDLL YNVLRSPMSF FERTPSGNLV NRFSKELDTV 
DSMIPQVIKM FMGSLFSVIG AVIIILLATP IAAVIIPPLG LVYFFVQRFY VASSRQLKRL 
ESVSRSPVYS HFNETLLGVS VIRAFEEQER FIHQSDLKVD ENQKAYYPSI VANRWLAVRL 
ECVGNCIVLF AALFAVISRH SLSAGLVGLS VSYSLQITAY LNWLVRMSSE METNIVAVER 
LKEYSETEKE APWQIQETAP PSTWPHSGRV EFRDYCLRYR EDLDLVLKHI NVTIEGGEKV 
GIVGRTGAGK SSLTLGLFRI NESAEGEIII DGVNIAKIGL HNLRFKITII PQDPVLFSGS 
LRMNLDPFSQ YSDEEVWMAL ELAHLKGFVS ALPDKLNHEC AEGGENLSVG QRQLVCLARA 
LLRKTKILVL DEATAAVDLE TDNLIQSTIR TQFEDCTVLT IAHRLNTIMD YTRVIVLDKG 
EVRECGAPSE LLQQRGIFYS MAKDAGLV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Abcc1

Associated with

Other Information

Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter. PubMed ID: 8649356

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. PubMed ID: 9281595

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. PubMed ID: 9359705

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP. PubMed ID: 36070769