Genular: Defining Cellular Identity and Function

Details for: Mecp2

Gene ID: 17257

Symbol: Mecp2

Ensembl ID: ENSMUSG00000031393

Description: methyl CpG binding protein 2

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Regulation of mecp2 expression and activity
(R-MMU-9022692)
Rna polymerase ii transcription
(R-MMU-73857)
Transcriptional regulation by mecp2
(R-MMU-8986944)
Adult locomotory behavior
(GO:0008344)
Associative learning
(GO:0008306)
Behavioral fear response
(GO:0001662)
Biogenic amine metabolic process
(GO:0006576)
Brain development
(GO:0007420)
Cardiolipin metabolic process
(GO:0032048)
Catecholamine secretion
(GO:0050432)
Cell population proliferation
(GO:0008283)
Cellular response to potassium ion
(GO:0035865)
Cerebellum development
(GO:0021549)
Chemical synaptic transmission
(GO:0007268)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Dendrite development
(GO:0016358)
Dna binding
(GO:0003677)
Double-stranded methylated dna binding
(GO:0010385)
Embryo development
(GO:0009790)
Enzyme binding
(GO:0019899)
Epigenetic regulation of gene expression
(GO:0040029)
Four-way junction dna binding
(GO:0000400)
Gene expression
(GO:0010467)
Glial cell proliferation
(GO:0014009)
Glucocorticoid metabolic process
(GO:0008211)
Glutamine metabolic process
(GO:0006541)
Heterochromatin formation
(GO:0031507)
Histone deacetylase binding
(GO:0042826)
Histone reader activity
(GO:0140566)
Identical protein binding
(GO:0042802)
Inositol metabolic process
(GO:0006020)
Learning
(GO:0007612)
Long-term memory
(GO:0007616)
Memory
(GO:0007613)
Methyl-cpg binding
(GO:0008327)
Molecular adaptor activity
(GO:0060090)
Molecular condensate scaffold activity
(GO:0140693)
Mrna binding
(GO:0003729)
Multicellular organismal response to stress
(GO:0033555)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of astrocyte differentiation
(GO:0048712)
Negative regulation of blood vessel endothelial cell migration
(GO:0043537)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system process involved in regulation of systemic arterial blood pressure
(GO:0001976)
Neuromuscular process controlling posture
(GO:0050884)
Neuron differentiation
(GO:0030182)
Neuron maturation
(GO:0042551)
Neuron projection development
(GO:0031175)
Notch signaling pathway
(GO:0007219)
Nucleic acid binding
(GO:0003676)
Phosphatidylcholine metabolic process
(GO:0046470)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of synaptic plasticity
(GO:0031915)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Post-embryonic development
(GO:0009791)
Promoter-specific chromatin binding
(GO:1990841)
Proprioception
(GO:0019230)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein localization
(GO:0008104)
Regulation of dna methylation
(GO:0044030)
Regulation of gene expression
(GO:0010468)
Regulation of respiratory gaseous exchange by nervous system process
(GO:0002087)
Regulation of synapse organization
(GO:0050807)
Regulation of synaptic plasticity
(GO:0048167)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Response to cocaine
(GO:0042220)
Response to hypoxia
(GO:0001666)
Sensory perception of pain
(GO:0019233)
Sirna binding
(GO:0035197)
Social behavior
(GO:0035176)
Startle response
(GO:0001964)
Synapse assembly
(GO:0007416)
Transcription corepressor activity
(GO:0003714)
Transcription factor binding
(GO:0008134)
Unmethylated cpg binding
(GO:0045322)
Ventricular system development
(GO:0021591)
Visual learning
(GO:0008542)

Other Information

Proteins

Methyl-CpG-binding protein 2

Genular Protein ID: 3875199594

Symbol: MECP2_MOUSE

Name: Methyl-CpG-binding protein 2

UniProtKB Accession Codes:

Q9Z2D6 B1AUZ2 B1AUZ3 Q3TYG1

Database IDs:

Citations:

PubMed ID: 9774669

Title: Identification and characterization of a family of mammalian methyl-CpG binding proteins.

PubMed ID: 9774669

DOI: 10.1128/mcb.18.11.6538

PubMed ID: 10369871

Title: A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3'-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression.

PubMed ID: 10369871

DOI: 10.1093/hmg/8.7.1253

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9171351

Title: FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.

PubMed ID: 9171351

DOI: 10.1093/emboj/16.9.2376

PubMed ID: 15034150

Title: The major form of MeCP2 has a novel N-terminus generated by alternative splicing.

PubMed ID: 15034150

DOI: 10.1093/nar/gkh349

PubMed ID: 17046689

Title: Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation.

PubMed ID: 17046689

DOI: 10.1016/j.neuron.2006.09.037

PubMed ID: 17296936

Title: Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.

PubMed ID: 17296936

DOI: 10.1073/pnas.0608056104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23434322

Title: Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives.

PubMed ID: 23434322

DOI: 10.1016/j.cell.2013.02.004

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23770565

Title: Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.

PubMed ID: 23770565

DOI: 10.1038/nn.3434

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28348241

Title: Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.

PubMed ID: 28348241

DOI: 10.1073/pnas.1700731114

Sequence Information:

Length: 484
Mass: 52307
Checksum: 62FD228F0118A49F
Sequence:

MVAGMLGLRE EKSEDQDLQG LRDKPLKFKK AKKDKKEDKE GKHEPLQPSA HHSAEPAEAG 
KAETSESSGS APAVPEASAS PKQRRSIIRD RGPMYDDPTL PEGWTRKLKQ RKSGRSAGKY 
DVYLINPQGK AFRSKVELIA YFEKVGDTSL DPNDFDFTVT GRGSPSRREQ KPPKKPKSPK 
APGTGRGRGR PKGSGTGRPK AAASEGVQVK RVLEKSPGKL VVKMPFQASP GGKGEGGGAT 
TSAQVMVIKR PGRKRKAEAD PQAIPKKRGR KPGSVVAAAA AEAKKKAVKE SSIRSVHETV 
LPIKKRKTRE TVSIEVKEVV KPLLVSTLGE KSGKGLKTCK SPGRKSKESS PKGRSSSASS 
PPKKEHHHHH HHSESTKAPM PLLPSPPPPE PESSEDPISP PEPQDLSSSI CKEEKMPRGG 
SLESDGCPKE PAKTQPMVAT TTTVAEKYKH RGEGERKDIV SSSMPRPNRE EPVDSRTPVT 
ERVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mecp2

Associated with

Other Information

Identification and characterization of a family of mammalian methyl-CpG binding proteins. PubMed ID: 9774669

A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3'-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression. PubMed ID: 10369871

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. PubMed ID: 9171351

The major form of MeCP2 has a novel N-terminus generated by alternative splicing. PubMed ID: 15034150

Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. PubMed ID: 17046689

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. PubMed ID: 17296936

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. PubMed ID: 23434322

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. PubMed ID: 23770565

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders. PubMed ID: 28348241