Details for: CYB5R3
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 32.16rCSI 27.72%PRS 29.93
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CSI 28.01rCSI 29.35%PRS 20.41
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CSI 23.78rCSI 19.32%PRS 20.23
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CSI 23.63rCSI 68.41%PRS 21.64
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CSI 21.63rCSI 27.53%PRS 22.23
-
CSI 21.36rCSI 22.33%PRS 19.98
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CSI 19.16rCSI 37.27%PRS 19.59
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CSI 18.38rCSI 44.17%PRS 28.26
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CSI 17.95rCSI 28.66%PRS 21.02
-
CSI 17.64rCSI 24.03%PRS 16.95
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CSI 17.19rCSI 25.19%PRS 67.86
-
CSI 15.45rCSI 30.61%PRS 51.03
-
CSI 14.34rCSI 34.4%PRS 34
-
CSI 13.74rCSI 20.98%PRS 19.28
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CSI 11.94rCSI 47.54%PRS 32.8
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CSI 11.81rCSI 16.35%PRS 27.06
-
CSI 11.56rCSI 50.16%PRS 33.28
-
CSI 11.2rCSI 9.35%PRS 49.18
-
CSI 11.15rCSI 16.31%PRS 20.28
-
CSI 10.76rCSI 62.58%PRS 28.43
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CSI 10.57rCSI 37.52%PRS 31.05
-
CSI 10.1rCSI 47.09%PRS 42.45
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CSI 9.94rCSI 13.59%PRS 21.68
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CSI 9.89rCSI 67.93%PRS 36.94
-
CSI 9.76rCSI 26.81%PRS 31.37
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CSI 9.67rCSI 13.16%PRS 28.93
-
CSI 8.95rCSI 9.51%PRS 32.9
-
CSI 8.95rCSI 6.22%PRS 22.86
-
CSI 7.59rCSI 40.93%PRS 33.55
-
CSI 7.52rCSI 16.62%PRS 13.73
-
CSI 7.35rCSI 5.45%PRS 16.67
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CSI 7.16rCSI 4.98%PRS 27.09
-
CSI 7.07rCSI 7.75%PRS 21.63
-
CSI 6.89rCSI 9.89%PRS 14.84
-
CSI 6.84rCSI 54.57%PRS 63.35
-
CSI 6.66rCSI 15.54%PRS 43.88
-
CSI 6.07rCSI 4.09%PRS 23.41
-
CSI 6.07rCSI 24.72%PRS 19.51
-
CSI 5.82rCSI 25.88%PRS 18.77
-
CSI 5.74rCSI 44.03%PRS 51.79
-
CSI 5.4rCSI 22.4%PRS 34.85
-
CSI 5.31rCSI 28.92%PRS 44.2
-
CSI 5.23rCSI 12.27%PRS 27.59
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CSI 5.19rCSI 6.66%PRS 22.15
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CSI 5.15rCSI 12.28%PRS 48.61
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CSI 5.07rCSI 7.84%PRS 17.94
-
CSI 4.87rCSI 10.93%PRS 37.69
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CSI 4.86rCSI 4.09%PRS 30.37
-
CSI 4.72rCSI 70.8%PRS 52.6
-
CSI 4.49rCSI 7.94%PRS 11.25
-
CSI 4.48rCSI 4.14%PRS 34.41
-
CSI 4.42rCSI 5.28%PRS 11.08
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CSI 4.37rCSI 25.05%PRS 55.48
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CSI 4.21rCSI 11.83%PRS 25.82
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CSI 4.19rCSI 30.62%PRS 49.8
-
CSI 3.97rCSI 3.08%PRS 18.35
-
CSI 3.96rCSI 2.34%PRS 26.74
-
CSI 3.89rCSI 7.41%PRS 30.31
-
CSI 3.81rCSI 3.6%PRS 20.08
-
CSI 3.7rCSI 21.24%PRS 28.85
-
CSI 3.7rCSI 3.65%PRS 62.35
-
CSI 3.64rCSI 3.29%PRS 17.2
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CSI 3.6rCSI 2.89%PRS 34.2
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CSI 3.58rCSI 2.71%PRS 26.23
-
CSI 3.53rCSI 2.35%PRS 22.95
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CSI 3.5rCSI 13.12%PRS 16.17
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CSI 3.5rCSI 5.53%PRS 19.25
-
CSI 3.49rCSI 3.44%PRS 20.71
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CSI 3.45rCSI 6.84%PRS 46
-
CSI 3.39rCSI 5.79%PRS 38.41
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CSI 3.37rCSI 7.64%PRS 25.94
-
CSI 3.33rCSI 5.11%PRS 26.3
-
CSI 3.26rCSI 3.5%PRS 17.65
-
CSI 3.26rCSI 4.19%PRS 18.58
-
CSI 3.22rCSI 4.01%PRS 20.35
-
CSI 3.18rCSI 25.85%PRS 19.38
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CSI 3.17rCSI 10.29%PRS 23.07
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CSI 3.16rCSI 2.9%PRS 22.37
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CSI 3.12rCSI 6.47%PRS 19.09
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CSI 3.11rCSI 2.73%PRS 21.99
-
CSI 3.06rCSI 4.96%PRS 19.32
-
CSI 3.06rCSI 6.15%PRS 14.16
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CSI 3rCSI 6.09%PRS 9.54
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CSI 2.95rCSI 14.13%PRS 23.59
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CSI 2.88rCSI 3.02%PRS 17.87
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CSI 2.87rCSI 2%PRS 20.36
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CSI 2.82rCSI 2.15%PRS 25.31
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CSI 2.81rCSI 4.11%PRS 25.15
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CSI 2.8rCSI 2.26%PRS 19.15
-
CSI 2.76rCSI 2.06%PRS 30.36
-
CSI 2.72rCSI 2.28%PRS 22.83
-
CSI 2.63rCSI 3.77%PRS 26
-
CSI 2.57rCSI 49.58%PRS 52.86
-
CSI 2.53rCSI 27.51%PRS 36.36
-
CSI 2.52rCSI 4.36%PRS 14.61
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CSI 2.51rCSI 3.9%PRS 28.59
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CSI 2.5rCSI 5.54%PRS 17.71
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CSI 2.43rCSI 2.39%PRS 29.87
-
CSI 2.42rCSI 3.87%PRS 16.41
-
CSI 2.38rCSI 3.71%PRS 43.77
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CSI -3.6rCSI -4.8%PRS 27.3%
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CSI -1.0rCSI -2.3%PRS 23.6%
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CSI 0.1rCSI 0.4%PRS 31.5%
-
CSI 0.1rCSI 0.2%PRS 12.3%
-
CSI 0.1rCSI 0.2%PRS 14.7%
-
CSI 0.2rCSI 4.4%PRS 80.9%
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CSI 0.2rCSI 0.7%PRS 10.6%
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CSI 0.2rCSI 1.2%PRS 28.1%
-
CSI 0.2rCSI 1.2%PRS 32.6%
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CSI 0.2rCSI 4.4%PRS 53.0%
-
CSI 0.3rCSI 0.7%PRS 14.7%
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CSI 0.3rCSI 3.0%PRS 56.6%
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CSI 0.3rCSI 1.7%PRS 14.9%
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CSI 0.3rCSI 1.1%PRS 25.9%
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CSI 0.3rCSI 0.8%PRS 24.7%
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CSI 0.3rCSI 0.9%PRS 13.0%
-
CSI 0.3rCSI 1.7%PRS 59.1%
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CSI 0.3rCSI 1.5%PRS 35.2%
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CSI 0.4rCSI 1.7%PRS 26.0%
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CSI 0.4rCSI 0.5%PRS 22.8%
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CSI 0.4rCSI 1.1%PRS 20.1%
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CSI 0.4rCSI 0.5%PRS 29.4%
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CSI 0.4rCSI 0.6%PRS 30.9%
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CSI 0.4rCSI 1.8%PRS 39.4%
-
CSI 0.4rCSI 1.3%PRS 12.1%
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CSI 0.4rCSI 0.6%PRS 19.3%
-
CSI 0.4rCSI 1.9%PRS 47.4%
-
CSI 0.4rCSI 1.1%PRS 24.8%
-
CSI 0.4rCSI 1.4%PRS 63.6%
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CSI 0.5rCSI 0.6%PRS 11.8%
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CSI 0.5rCSI 0.8%PRS 29.2%
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CSI 0.5rCSI 4.6%PRS 49.7%
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CSI 0.5rCSI 1.2%PRS 14.5%
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CSI 0.5rCSI 1.1%PRS 11.8%
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CSI 0.5rCSI 0.4%PRS 33.9%
-
CSI 0.5rCSI 14.9%PRS 42.0%
-
CSI 0.5rCSI 1.0%PRS 42.8%
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CSI 0.5rCSI 3.6%PRS 52.2%
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CSI 0.5rCSI 1.5%PRS 17.7%
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CSI 0.5rCSI 5.8%PRS 61.9%
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CSI 0.5rCSI 1.1%PRS 31.9%
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CSI 0.6rCSI 0.5%PRS 24.0%
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CSI 0.6rCSI 1.0%PRS 17.7%
-
CSI 0.6rCSI 3.1%PRS 33.9%
-
CSI 0.6rCSI 1.7%PRS 33.6%
-
CSI 0.6rCSI 1.9%PRS 27.5%
-
CSI 0.6rCSI 3.6%PRS 59.7%
-
CSI 0.6rCSI 3.2%PRS 37.1%
-
CSI 0.6rCSI 0.9%PRS 29.9%
-
CSI 0.6rCSI 1.4%PRS 29.1%
-
CSI 0.6rCSI 1.6%PRS 17.7%
-
CSI 0.7rCSI 1.9%PRS 32.5%
-
CSI 0.7rCSI 15.9%PRS 56.0%
-
CSI 0.7rCSI 3.8%PRS 55.6%
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CSI 0.7rCSI 1.3%PRS 42.0%
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CSI 0.7rCSI 0.8%PRS 18.7%
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CSI 0.7rCSI 1.6%PRS 19.8%
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CSI 0.7rCSI 1.0%PRS 30.3%
-
CSI 0.7rCSI 1.5%PRS 37.1%
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CSI 0.7rCSI 2.0%PRS 35.7%
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CSI 0.7rCSI 6.5%PRS 61.5%
-
CSI 0.8rCSI 0.8%PRS 16.3%
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CSI 0.8rCSI 0.6%PRS 23.1%
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CSI 0.8rCSI 2.1%PRS 19.3%
-
CSI 0.8rCSI 3.9%PRS 38.1%
-
CSI 0.8rCSI 1.0%PRS 22.9%
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CSI 0.8rCSI 4.7%PRS 48.2%
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CSI 0.8rCSI 1.1%PRS 21.0%
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CSI 0.9rCSI 1.9%PRS 25.6%
-
CSI 0.9rCSI 2.1%PRS 11.1%
-
CSI 0.9rCSI 3.0%PRS 33.3%
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CSI 0.9rCSI 2.1%PRS 22.1%
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CSI 0.9rCSI 2.6%PRS 43.8%
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CSI 0.9rCSI 3.9%PRS 18.1%
-
CSI 0.9rCSI 1.3%PRS 19.6%
-
CSI 0.9rCSI 1.9%PRS 41.4%
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CSI 0.9rCSI 2.4%PRS 23.7%
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CSI 1.0rCSI 21.6%PRS 66.2%
-
CSI 1.0rCSI 1.2%PRS 24.8%
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CSI 1.0rCSI 4.4%PRS 57.7%
-
CSI 1.0rCSI 1.3%PRS 30.0%
-
CSI 1.0rCSI 1.6%PRS 24.6%
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CSI 1.0rCSI 26.4%PRS 68.1%
-
CSI 1.0rCSI 1.5%PRS 28.8%
-
CSI 1.1rCSI 1.2%PRS 16.8%
-
CSI 1.1rCSI 3.0%PRS 29.6%
-
CSI 1.1rCSI 8.0%PRS 34.8%
-
CSI 1.1rCSI 6.3%PRS 24.5%
-
CSI 1.1rCSI 6.0%PRS 30.1%
-
CSI 1.1rCSI 4.4%PRS 40.2%
-
CSI 1.1rCSI 2.7%PRS 29.0%
-
CSI 1.1rCSI 1.1%PRS 38.7%
-
CSI 1.1rCSI 3.0%PRS 37.0%
-
CSI 1.1rCSI 1.7%PRS 17.8%
-
CSI 1.2rCSI 2.2%PRS 37.3%
-
CSI 1.2rCSI 1.6%PRS 25.0%
-
CSI 1.2rCSI 15.8%PRS 54.9%
-
CSI 1.2rCSI 0.9%PRS 17.7%
-
CSI 1.2rCSI 3.7%PRS 28.5%
-
CSI 1.2rCSI 2.2%PRS 31.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1683685757
Symbol: NB5R3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2479590
Title: The organization and the complete nucleotide sequence of the human NADH-cytochrome b5 reductase gene.
PubMed ID: 2479590
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3035541
Title: Molecular cloning of cDNAs of human liver and placenta NADH-cytochrome b5 reductase.
PubMed ID: 3035541
PubMed ID: 2498303
Title: The NH2-terminal structures of human and rat liver microsomal NADH-cytochrome b5 reductases.
PubMed ID: 2498303
PubMed ID: 3700359
Title: Complete amino acid sequence of NADH-cytochrome b5 reductase purified from human erythrocytes.
PubMed ID: 3700359
PubMed ID: 6389526
Title: Amino acid sequence of NADH-cytochrome b5 reductase of human erythrocytes.
PubMed ID: 6389526
PubMed ID: 9639531
Title: An erythroid-specific transcript generates the soluble form of NADH-cytochrome b5 reductase in humans.
PubMed ID: 9639531
PubMed ID: 2019583
Title: Role of cysteine residues in human NADH-cytochrome b5 reductase studied by site-directed mutagenesis. Cys-273 and Cys-283 are located close to the NADH-binding site but are not catalytically essential.
PubMed ID: 2019583
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25255805
Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
PubMed ID: 25255805
DOI: 10.1038/ncomms5919
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 15502298
Title: Structure of human erythrocyte NADH-cytochrome b5 reductase.
PubMed ID: 15502298
PubMed ID: 1898726
Title: Structural role of serine 127 in the NADH-binding site of human NADH-cytochrome b5 reductase.
PubMed ID: 1898726
PubMed ID: 1707593
Title: Exonic point mutations in NADH-cytochrome B5 reductase genes of homozygotes for hereditary methemoglobinemia, types I and III: putative mechanisms of tissue-dependent enzyme deficiency.
PubMed ID: 1707593
PubMed ID: 1400360
Title: Enzymatic instability of NADH-cytochrome b5 reductase as a cause of hereditary methemoglobinemia type I (red cell type).
PubMed ID: 1400360
PubMed ID: 8119939
Title: An in-frame deletion of codon 298 of the NADH-cytochrome b5 reductase gene results in hereditary methemoglobinemia type II (generalized type). A functional implication for the role of the COOH-terminal region of the enzyme.
PubMed ID: 8119939
PubMed ID: 7718898
Title: Four new mutations in the NADH-cytochrome b5 reductase gene from patients with recessive congenital methemoglobinemia type II.
PubMed ID: 7718898
PubMed ID: 9048929
Title: A high-frequency polymorphism of NADH-cytochrome b5 reductase in African-Americans.
PubMed ID: 9048929
PubMed ID: 9695975
Title: Identification of a novel point mutation (Leu72-to-Pro) in the NADH-cytochrome b5 reductase gene of a patient with hereditary methaemoglobinaemia type I.
PubMed ID: 9695975
PubMed ID: 9886302
Title: Molecular basis of hereditary methaemoglobinaemia, types I and II: two novel mutations in the NADH-cytochrome b5 reductase gene.
PubMed ID: 9886302
PubMed ID: 10807796
Title: A novel mutation in the NADH-cytochrome b5 reductase gene of a Chinese patient with recessive congenital methemoglobinemia.
PubMed ID: 10807796
PubMed ID: 15622768
Title: Arginine-glutamine replacement at residue 57 of NADH-cytochrome b5 reductase in Chinese hereditary methemoglobinemia.
PubMed ID: 15622768
PubMed ID: 12393396
Title: Familial idiopathic methemoglobinemia revisited: original cases reveal 2 novel mutations in NADH-cytochrome b5 reductase.
PubMed ID: 12393396
PubMed ID: 15953014
Title: Recessive congenital methaemoglobinaemia: functional characterization of the novel D239G mutation in the NADH-binding lobe of cytochrome b5 reductase.
PubMed ID: 15953014
Sequence Information:
- Length: 301
- Mass: 34235
- Checksum: FDCDCDC4EC3570B4
- Sequence:
MGAQLSTLGH MVLFPVWFLY SLLMKLFQRS TPAITLESPD IKYPLRLIDR EIISHDTRRF RFALPSPQHI LGLPVGQHIY LSARIDGNLV VRPYTPISSD DDKGFVDLVI KVYFKDTHPK FPAGGKMSQY LESMQIGDTI EFRGPSGLLV YQGKGKFAIR PDKKSNPIIR TVKSVGMIAG GTGITPMLQV IRAIMKDPDD HTVCHLLFAN QTEKDILLRP ELEELRNKHS ARFKLWYTLD RAPEAWDYGQ GFVNEEMIRD HLPPPEEEPL VLMCGPPPMI QYACLPNLDH VGHPTERCFV F