Details for: CYB5R3

Gene ID: 1727

Symbol: CYB5R3

Ensembl ID: ENSG00000100243

Description: cytochrome b5 reductase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 2.31
    Marker Score: 2263
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.28
    Marker Score: 5973
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.27
    Marker Score: 9790
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.24
    Marker Score: 39802
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.23
    Marker Score: 4195
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.19
    Marker Score: 801
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.19
    Marker Score: 22011
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.16
    Marker Score: 5892
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.13
    Marker Score: 72377
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.1
    Marker Score: 1492
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.09
    Marker Score: 1967
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.06
    Marker Score: 2830
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.05
    Marker Score: 2206
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.03
    Marker Score: 849
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.03
    Marker Score: 574
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.02
    Marker Score: 13154
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.98
    Marker Score: 3949
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.95
    Marker Score: 3294
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.93
    Marker Score: 3208
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.93
    Marker Score: 2329
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.93
    Marker Score: 2052
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.93
    Marker Score: 2377
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.92
    Marker Score: 442
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.91
    Marker Score: 643
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.91
    Marker Score: 16787
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.91
    Marker Score: 1642
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.9
    Marker Score: 48718
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.89
    Marker Score: 2791
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.87
    Marker Score: 1095
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.87
    Marker Score: 1232
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.85
    Marker Score: 1768
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.84
    Marker Score: 11977
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.83
    Marker Score: 13645
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.83
    Marker Score: 2057.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.81
    Marker Score: 2910
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.8
    Marker Score: 990
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.8
    Marker Score: 1610
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.79
    Marker Score: 1728
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.79
    Marker Score: 10610
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.78
    Marker Score: 1912
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.78
    Marker Score: 4178.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.76
    Marker Score: 1278
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.76
    Marker Score: 1790
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.76
    Marker Score: 19831
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.75
    Marker Score: 4419
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.75
    Marker Score: 432
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.72
    Marker Score: 6775
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.71
    Marker Score: 384
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.69
    Marker Score: 3535
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.69
    Marker Score: 2775
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.69
    Marker Score: 1522
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.68
    Marker Score: 2670
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.68
    Marker Score: 58029
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.67
    Marker Score: 1057
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.67
    Marker Score: 22028
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.67
    Marker Score: 473
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.66
    Marker Score: 620
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.65
    Marker Score: 4910
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.65
    Marker Score: 2392
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.63
    Marker Score: 563
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.62
    Marker Score: 853
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.61
    Marker Score: 4092
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.57
    Marker Score: 1840
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.57
    Marker Score: 977
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.56
    Marker Score: 1043
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.55
    Marker Score: 878
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.55
    Marker Score: 5509.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.55
    Marker Score: 537
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.55
    Marker Score: 641
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.54
    Marker Score: 1633
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.54
    Marker Score: 20681.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.54
    Marker Score: 2232
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.54
    Marker Score: 450
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.53
    Marker Score: 2604
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.53
    Marker Score: 617
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.53
    Marker Score: 491
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.52
    Marker Score: 364
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.52
    Marker Score: 1909
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.52
    Marker Score: 365
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.52
    Marker Score: 786
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.52
    Marker Score: 931
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.51
    Marker Score: 2753
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.51
    Marker Score: 655
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.5
    Marker Score: 712
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.5
    Marker Score: 1506
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.49
    Marker Score: 1552
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.49
    Marker Score: 523
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.49
    Marker Score: 9504
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.48
    Marker Score: 359
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.48
    Marker Score: 1483
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.48
    Marker Score: 1905
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.47
    Marker Score: 1007
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.47
    Marker Score: 696
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.47
    Marker Score: 1231
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.47
    Marker Score: 514
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.47
    Marker Score: 1693
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.47
    Marker Score: 707
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.46
    Marker Score: 914
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.46
    Marker Score: 3917.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.46
    Marker Score: 4575

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Other Information

**Key characteristics:** * It is a member of the cytochrome b5 family of proteins, which are involved in electron transport reactions. * It is a key regulator of cellular metabolism and inflammation. * It is involved in the regulation of immune responses, including the activation of neutrophils and the regulation of inflammation. **Pathways and functions:** * CYB5R3 is involved in several pathways, including adp binding, amp binding, biological oxidations, cholesterol biosynthetic process, cytochrome-b5 reductase activity, acting on nad(p)h, Fad binding, immune system, innate immune system, metabolism, vitamin c (ascorbate) metabolism, and the nitrite reductase (no-forming) activity. **Clinical significance:** * Mutations in the CYB5R3 gene have been linked to several human diseases, including cancer and cardiovascular disease. * Inhibition of CYB5R3 has been shown to have anti-tumorigenic effects in cancer cells. * Therefore, targeting the CYB5R3 gene is a promising strategy for cancer treatment.

Genular Protein ID: 1683685757

Symbol: NB5R3_HUMAN

Name: N/A

UniProtKB Accession Codes:

P00387 B1AHF2 B7Z7L3 O75675 Q8TDL8 Q8WTS8 Q9UEN4 Q9UEN5 Q9UL55 Q9UL56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 2 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 25 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 3 RefSeq 5 Rhea 8 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2479590

Title: The organization and the complete nucleotide sequence of the human NADH-cytochrome b5 reductase gene.

PubMed ID: 2479590

DOI: 10.1016/0378-1119(89)90299-0

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3035541

Title: Molecular cloning of cDNAs of human liver and placenta NADH-cytochrome b5 reductase.

PubMed ID: 3035541

DOI: 10.1073/pnas.84.11.3609

PubMed ID: 2498303

Title: The NH2-terminal structures of human and rat liver microsomal NADH-cytochrome b5 reductases.

PubMed ID: 2498303

DOI: 10.1093/oxfordjournals.jbchem.a122659

PubMed ID: 3700359

Title: Complete amino acid sequence of NADH-cytochrome b5 reductase purified from human erythrocytes.

PubMed ID: 3700359

DOI: 10.1093/oxfordjournals.jbchem.a135495

PubMed ID: 6389526

Title: Amino acid sequence of NADH-cytochrome b5 reductase of human erythrocytes.

PubMed ID: 6389526

DOI: 10.1093/oxfordjournals.jbchem.a134871

PubMed ID: 9639531

Title: An erythroid-specific transcript generates the soluble form of NADH-cytochrome b5 reductase in humans.

PubMed ID: 9639531

PubMed ID: 2019583

Title: Role of cysteine residues in human NADH-cytochrome b5 reductase studied by site-directed mutagenesis. Cys-273 and Cys-283 are located close to the NADH-binding site but are not catalytically essential.

PubMed ID: 2019583

DOI: 10.1016/s0021-9258(20)89479-4

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15502298

Title: Structure of human erythrocyte NADH-cytochrome b5 reductase.

PubMed ID: 15502298

DOI: 10.1107/s0907444904020645

PubMed ID: 1898726

Title: Structural role of serine 127 in the NADH-binding site of human NADH-cytochrome b5 reductase.

PubMed ID: 1898726

DOI: 10.1016/s0021-9258(18)52402-9

PubMed ID: 1707593

Title: Exonic point mutations in NADH-cytochrome B5 reductase genes of homozygotes for hereditary methemoglobinemia, types I and III: putative mechanisms of tissue-dependent enzyme deficiency.

PubMed ID: 1707593

PubMed ID: 1400360

Title: Enzymatic instability of NADH-cytochrome b5 reductase as a cause of hereditary methemoglobinemia type I (red cell type).

PubMed ID: 1400360

DOI: 10.1016/s0021-9258(19)88718-5

PubMed ID: 8119939

Title: An in-frame deletion of codon 298 of the NADH-cytochrome b5 reductase gene results in hereditary methemoglobinemia type II (generalized type). A functional implication for the role of the COOH-terminal region of the enzyme.

PubMed ID: 8119939

DOI: 10.1016/s0021-9258(17)37554-3

PubMed ID: 7718898

Title: Four new mutations in the NADH-cytochrome b5 reductase gene from patients with recessive congenital methemoglobinemia type II.

PubMed ID: 7718898

PubMed ID: 9048929

Title: A high-frequency polymorphism of NADH-cytochrome b5 reductase in African-Americans.

PubMed ID: 9048929

DOI: 10.1007/s004390050347

PubMed ID: 9695975

Title: Identification of a novel point mutation (Leu72-to-Pro) in the NADH-cytochrome b5 reductase gene of a patient with hereditary methaemoglobinaemia type I.

PubMed ID: 9695975

DOI: 10.1046/j.1365-2141.1998.00782.x

PubMed ID: 9886302

Title: Molecular basis of hereditary methaemoglobinaemia, types I and II: two novel mutations in the NADH-cytochrome b5 reductase gene.

PubMed ID: 9886302

DOI: 10.1046/j.1365-2141.1998.01123.x

PubMed ID: 10807796

Title: A novel mutation in the NADH-cytochrome b5 reductase gene of a Chinese patient with recessive congenital methemoglobinemia.

PubMed ID: 10807796

PubMed ID: 15622768

Title: Arginine-glutamine replacement at residue 57 of NADH-cytochrome b5 reductase in Chinese hereditary methemoglobinemia.

PubMed ID: 15622768

PubMed ID: 12393396

Title: Familial idiopathic methemoglobinemia revisited: original cases reveal 2 novel mutations in NADH-cytochrome b5 reductase.

PubMed ID: 12393396

DOI: 10.1182/blood-2002-05-1405

PubMed ID: 15953014

Title: Recessive congenital methaemoglobinaemia: functional characterization of the novel D239G mutation in the NADH-binding lobe of cytochrome b5 reductase.

PubMed ID: 15953014

DOI: 10.1111/j.1365-2141.2005.05526.x

Sequence Information:

  • Length: 301
  • Mass: 34235
  • Checksum: FDCDCDC4EC3570B4
  • Sequence:
    • MGAQLSTLGH MVLFPVWFLY SLLMKLFQRS TPAITLESPD IKYPLRLIDR EIISHDTRRF 
RFALPSPQHI LGLPVGQHIY LSARIDGNLV VRPYTPISSD DDKGFVDLVI KVYFKDTHPK 
FPAGGKMSQY LESMQIGDTI EFRGPSGLLV YQGKGKFAIR PDKKSNPIIR TVKSVGMIAG 
GTGITPMLQV IRAIMKDPDD HTVCHLLFAN QTEKDILLRP ELEELRNKHS ARFKLWYTLD 
RAPEAWDYGQ GFVNEEMIRD HLPPPEEEPL VLMCGPPPMI QYACLPNLDH VGHPTERCFV 
F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.