Genular: Defining Cellular Identity and Function

Details for: Rab8a

Gene ID: 17274

Symbol: Rab8a

Ensembl ID: ENSMUSG00000003037

Description: RAB8A, member RAS oncogene family

Associated with

Anchoring of the basal body to the plasma membrane
(R-MMU-5620912)
Cargo trafficking to the periciliary membrane
(R-MMU-5620920)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
G2/m transition
(R-MMU-69275)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Mitotic g2-g2/m phases
(R-MMU-453274)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Post-translational protein modification
(R-MMU-597592)
Rab gefs exchange gtp for gdp on rabs
(R-MMU-8876198)
Rab geranylgeranylation
(R-MMU-8873719)
Rab regulation of trafficking
(R-MMU-9007101)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Tbc/rabgaps
(R-MMU-8854214)
Vesicle-mediated transport
(R-MMU-5653656)
Vxpx cargo-targeting to cilium
(R-MMU-5620916)
Autophagy
(GO:0006914)
Axonogenesis
(GO:0007409)
Cell projection
(GO:0042995)
Cell projection organization
(GO:0030030)
Cellular response to insulin stimulus
(GO:0032869)
Centrosome
(GO:0005813)
Ciliary basal body
(GO:0036064)
Ciliary base
(GO:0097546)
Ciliary membrane
(GO:0060170)
Cilium
(GO:0005929)
Cilium assembly
(GO:0060271)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytoplasmic vesicle membrane
(GO:0030659)
Cytoskeleton
(GO:0005856)
Dendrite
(GO:0030425)
Dendritic spine
(GO:0043197)
Endocytic recycling
(GO:0032456)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Gdp binding
(GO:0019003)
Glutamatergic synapse
(GO:0098978)
Golgi apparatus
(GO:0005794)
Golgi organization
(GO:0007030)
Golgi vesicle fusion to target membrane
(GO:0048210)
G protein activity
(GO:0003925)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Membrane
(GO:0016020)
Midbody
(GO:0030496)
Myosin v binding
(GO:0031489)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Neurotransmitter receptor transport, endosome to postsynaptic membrane
(GO:0098887)
Neurotransmitter receptor transport to postsynaptic membrane
(GO:0098969)
Non-motile cilium
(GO:0097730)
Nucleotide binding
(GO:0000166)
Phagocytic vesicle
(GO:0045335)
Plasma membrane
(GO:0005886)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein localization to cilium
(GO:0061512)
Protein localization to plasma membrane
(GO:0072659)
Protein secretion
(GO:0009306)
Protein transport
(GO:0015031)
Protein tyrosine kinase binding
(GO:1990782)
Recycling endosome
(GO:0055037)
Recycling endosome membrane
(GO:0055038)
Regulation of autophagy
(GO:0010506)
Regulation of exocytosis
(GO:0017157)
Regulation of long-term neuronal synaptic plasticity
(GO:0048169)
Regulation of protein localization
(GO:0032880)
Regulation of protein transport
(GO:0051223)
Synapse
(GO:0045202)
Synaptic vesicle
(GO:0008021)
Trans-golgi network transport vesicle
(GO:0030140)
Vesicle-mediated transport in synapse
(GO:0099003)
Vesicle docking involved in exocytosis
(GO:0006904)

Other Information

Proteins

Ras-related protein Rab-8A

Genular Protein ID: 3949881297

Symbol: RAB8A_MOUSE

Name: Ras-related protein Rab-8A

UniProtKB Accession Codes:

P55258 Q8VCF6

Database IDs:

Citations:

PubMed ID: 1886711

Title: The MEL gene: a new member of the RAB/YPT class of RAS-related genes.

PubMed ID: 1886711

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8643544

Title: In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase.

PubMed ID: 8643544

DOI: 10.1073/pnas.93.10.5151

PubMed ID: 12578829

Title: Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.

PubMed ID: 12578829

DOI: 10.1074/jbc.m212341200

PubMed ID: 12590134

Title: Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.

PubMed ID: 12590134

DOI: 10.1074/jbc.m213090200

PubMed ID: 17509819

Title: Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.

PubMed ID: 17509819

DOI: 10.1016/j.ygeno.2007.03.013

PubMed ID: 18094055

Title: The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.

PubMed ID: 18094055

DOI: 10.1091/mbc.e07-06-0551

PubMed ID: 19625297

Title: Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking.

PubMed ID: 19625297

DOI: 10.1093/hmg/ddp335

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20643351

Title: Pitchfork regulates primary cilia disassembly and left-right asymmetry.

PubMed ID: 20643351

DOI: 10.1016/j.devcel.2010.06.005

PubMed ID: 23807208

Title: The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.

PubMed ID: 23807208

DOI: 10.1007/s00018-013-1401-6

PubMed ID: 25860027

Title: GSK3beta-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.

PubMed ID: 25860027

DOI: 10.1371/journal.pbio.1002129

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

PubMed ID: 16541104

Title: Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.

PubMed ID: 16541104

DOI: 10.1038/sj.emboj.7601044

Sequence Information:

Length: 207
Mass: 23668
Checksum: AC89DC85588FB8F8
Sequence:

MAKTYDYLFK LLLIGDSGVG KTCVLFRFSE DAFNSTFIST IGIDFKIRTI ELDGKRIKLQ 
IWDTAGQERF RTITTAYYRG AMGIMLVYDI TNEKSFDNIR NWIRNIEEHA SADVEKMILG 
NKCDVNDKRQ VSKERGEKLA LDYGIKFMET SAKANINVEN AFFTLARDIK AKMDKKLEGN 
SPQGSSHGVK ITVEQQKRTS FFRCSLL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rab8a

Associated with

Other Information

The MEL gene: a new member of the RAB/YPT class of RAS-related genes. PubMed ID: 1886711

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. PubMed ID: 8643544

Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. PubMed ID: 12578829

Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. PubMed ID: 12590134

Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. PubMed ID: 17509819

The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions. PubMed ID: 18094055

Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking. PubMed ID: 19625297

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Pitchfork regulates primary cilia disassembly and left-right asymmetry. PubMed ID: 20643351

The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis. PubMed ID: 23807208

GSK3beta-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis. PubMed ID: 25860027

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. PubMed ID: 26824392

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. PubMed ID: 29125462

Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4. PubMed ID: 16541104