Genular: Defining Cellular Identity and Function

Details for: Melk

Gene ID: 17279

Symbol: Melk

Ensembl ID: ENSMUSG00000035683

Description: maternal embryonic leucine zipper kinase

Associated with

Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Calcium ion binding
(GO:0005509)
Cell cortex
(GO:0005938)
Cell cycle
(GO:0007049)
Cell population proliferation
(GO:0008283)
Cytoplasm
(GO:0005737)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
Kinase activity
(GO:0016301)
Lipid binding
(GO:0008289)
Membrane
(GO:0016020)
Neural precursor cell proliferation
(GO:0061351)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleotide binding
(GO:0000166)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein tyrosine kinase activity
(GO:0004713)
Transferase activity
(GO:0016740)

Other Information

Proteins

Maternal embryonic leucine zipper kinase

Genular Protein ID: 1316558105

Symbol: MELK_MOUSE

Name: Maternal embryonic leucine zipper kinase

UniProtKB Accession Codes:

Q61846 Q3TPU1 Q61804 Q6ZQH6

Database IDs:

Citations:

PubMed ID: 9305775

Title: Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells.

PubMed ID: 9305775

DOI: 10.1016/s0378-1119(97)00181-9

PubMed ID: 9136115

Title: New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo.

PubMed ID: 9136115

DOI: 10.1002/(sici)1098-2795(199706)47:2<148::aid-mrd4>3.0.co;2-m

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 14621295

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 14621295

DOI: 10.1093/dnares/10.4.167

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 16061694

Title: Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.

PubMed ID: 16061694

DOI: 10.1083/jcb.200412115

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18948261

Title: Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation.

PubMed ID: 18948261

DOI: 10.1074/jbc.m807219200

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 643
Mass: 72729
Checksum: 5637D2A4E8CFA216
Sequence:

MKDYDELLKY YELYETIGTG GFAKVKLACH VLTGEMVAIK IMDKNALGSD LPRVKTEIDA 
LKSLRHQHIC QLYHVLETKN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VVFRQILSAV 
AYVHSQGYAH RDLKPENLLF DENHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI 
QGKSYLGSEA DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYEVPK WLSPSSILLL 
QQMLQVDPKK RISMRNLLNH PWVMQDYSCP VEWQSKTPLT HLDEDCVTEL SVHHRSSRQT 
MEDLISSWQY DHLTATYLLL LAKKARGKPA RLQLLSFSCG TASTTPKSKN LSLEDMSTSD 
DNCVAGLIDY ELCEDKLLAP KTPQVTKHLA ESNHAASKSP APGVRRAVAN KLMDKENVCT 
PKSSVKNEEQ FVFSEPKIPV SKNQYKREIP ASPTRFPTPA KARAQCLREA PVRTPGNSAG 
ADTLTTGVIS PERRCRSMDV DLNQAHMEDT PKKKGTNVFG SLERGLDKVL TALTRNKKKG 
SARDGPRKRK LHYNVTTTRL VNPDQLLSEI MAILPKKNVD FVQKGYTLKC QTQSDFGKVT 
MQFELEVCQL QRPDVVGIRR QRLKGDAWVY KRLVEDILSG CKM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Melk

Associated with

Other Information

Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells. PubMed ID: 9305775

New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. PubMed ID: 9136115

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 14621295

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. PubMed ID: 16061694

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation. PubMed ID: 18948261

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079