Genular: Defining Cellular Identity and Function

Details for: Men1

Gene ID: 17283

Symbol: Men1

Ensembl ID: ENSMUSG00000024947

Description: multiple endocrine neoplasia 1

Associated with

Epigenetic regulation of gene expression
(R-MMU-212165)
Formation of the beta-catenin:tcf transactivating complex
(R-MMU-201722)
Formation of wdr5-containing histone-modifying complexes
(R-MMU-9772755)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate iqgaps
(R-MMU-5626467)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-MMU-2173796)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-MMU-2173793)
Cell division
(GO:0051301)
Cell population proliferation
(GO:0008283)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Chromatin remodeling
(GO:0006338)
Dna-binding transcription activator activity
(GO:0001216)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Double-stranded dna binding
(GO:0003690)
Embryo development
(GO:0009790)
Embryonic skeletal system morphogenesis
(GO:0048704)
Fibroblast apoptotic process
(GO:0044346)
Fibroblast proliferation
(GO:0048144)
Four-way junction dna binding
(GO:0000400)
Hemopoiesis
(GO:0030097)
Leukocyte homeostasis
(GO:0001776)
Mapk cascade
(GO:0000165)
Maternal process involved in female pregnancy
(GO:0060135)
Negative regulation of cell-substrate adhesion
(GO:0010812)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of fibroblast proliferation
(GO:0048147)
Negative regulation of jnk cascade
(GO:0046329)
Negative regulation of organ growth
(GO:0046621)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of telomerase activity
(GO:0051974)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Organ growth
(GO:0035265)
Ossification
(GO:0001503)
Osteoblast development
(GO:0002076)
Osteoblast fate commitment
(GO:0002051)
Phosphoprotein binding
(GO:0051219)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
R-smad binding
(GO:0070412)
Regulation of activin receptor signaling pathway
(GO:0032925)
Regulation of gene expression
(GO:0010468)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of type b pancreatic cell proliferation
(GO:0061469)
Response to gamma radiation
(GO:0010332)
Response to uv
(GO:0009411)
Roof of mouth development
(GO:0060021)
Sequence-specific dna binding
(GO:0043565)
Stem cell differentiation
(GO:0048863)
T-helper 2 cell differentiation
(GO:0045064)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription initiation-coupled chromatin remodeling
(GO:0045815)
Type b pancreatic cell differentiation
(GO:0003309)
Type b pancreatic cell proliferation
(GO:0044342)
Y-form dna binding
(GO:0000403)

Other Information

Proteins

Menin
A0A0R4J1I3_MOUSE

Genular Protein ID: 3200227114

Symbol: MEN1_MOUSE

Name: Menin

UniProtKB Accession Codes:

O88559 Q3U491 Q8CI72 Q91UZ7

Database IDs:

Citations:

PubMed ID: 9824159

Title: Characterization of the mouse Men1 gene and its expression during development.

PubMed ID: 9824159

DOI: 10.1038/sj.onc.1202164

PubMed ID: 10524203

Title: Primary structure, gene expression and chromosomal mapping of rodent homologs of the MEN1 tumor suppressor gene.

PubMed ID: 10524203

DOI: 10.1016/s0167-4781(99)00089-5

PubMed ID: 9893060

Title: Studies of the murine homolog of the multiple endocrine neoplasia type 1 (MEN1) gene, men1.

PubMed ID: 9893060

DOI: 10.1359/jbmr.1999.14.1.3

PubMed ID: 10341092

Title: Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene.

PubMed ID: 10341092

DOI: 10.1007/s003359901051

PubMed ID: 10612420

Title: Structure and distribution of rat menin mRNA.

PubMed ID: 10612420

DOI: 10.1016/s0303-7207(99)00150-1

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9989505

Title: Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.

PubMed ID: 9989505

DOI: 10.1016/s0092-8674(00)80967-8

PubMed ID: 11158604

Title: A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.

PubMed ID: 11158604

DOI: 10.1073/pnas.98.3.1118

PubMed ID: 16415155

Title: The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.

PubMed ID: 16415155

DOI: 10.1073/pnas.0510347103

Sequence Information:

Length: 611
Mass: 67501
Checksum: EF45DE5B5EB1B8D1
Sequence:

MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE 
LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK 
VSDVIWNSLS RSYFKDRAHI QSLFSFITGT KLDSSGVAFA VVGACQALGL RDVHLALSED 
HAWVVFGPNG EQTAEVTWHG KGNEDRRGQT VNAGVAERSW LYLKGSYMRC DRKMEVAFMV 
CAINPSIDLH TDSLELLQLQ QKLLWLLYDL GHLERYPMAL GNLADLEELE PTPGRPDPLT 
LYHKGIASAK TYYQDEHIYP YMYLAGYHCR NRNVREALQA WADTATVIQD YNYCREDEEI 
YKEFFEVAND VIPNLLKEAA SLLETGEERT GEQAQGTQGQ GSALQDPECF AHLLRFYDGI 
CKWEEGSPTP VLHVGWATFL VQSLGRFEGQ VRQKVHIVSR EAEAAEAEEP WGDEAREGRR 
RGPRRESKPE EPPPPKKPAL DKGPGSGQSA GSGPPRKTSG TVPGTTRGGQ EVGNAAQAPA 
PAASPPPEGP VLTFQSEKMK GMKELLVATK INSSAIKLQL TAQSQVQMKK QKVSTPSDYT 
LSFLKRQRKG L

Genular Protein ID: 129641962

Symbol: A0A0R4J1I3_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J1I3

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 617
Mass: 68065
Checksum: 9B8F27916147C679
Sequence:

MPPPAAMGLK AAQKTLFPLR SIDDVVRLFA AELGREEPDL VLLSLVLGFV EHFLAVNRVI 
PTNVPELTFQ PSPAPDPPGG LTYFPVADLS IIAALYARFT AQIRGAVDLS LYPREGGVSS 
RELVKKVSDV IWNSLSRSYF KDRAHIQSLF SFITGTKLDS SGVAFAVVGA CQALGLRDVH 
LALSEDHAWV VFGPNGEQTA EVTWHGKGNE DRRGQTVNAG VAERSWLYLK GSYMRCDRKM 
EVAFMVCAIN PSIDLHTDSL ELLQLQQKLL WLLYDLGHLE RYPMALGNLA DLEELEPTPG 
RPDPLTLYHK GIASAKTYYQ DEHIYPYMYL AGYHCRNRNV REALQAWADT ATVIQDYNYC 
REDEEIYKEF FEVANDVIPN LLKEAASLLE TGEERTGEQA QGTQGQGSAL QDPECFAHLL 
RFYDGICKWE EGSPTPVLHV GWATFLVQSL GRFEGQVRQK VHIVSREAEA AEAEEPWGDE 
AREGRRRGPR RESKPEEPPP PKKPALDKGP GSGQSAGSGP PRKTSGTVPG TTRGGQEVGN 
AAQAPAPAAS PPPEGPVLTF QSEKMKGMKE LLVATKINSS AIKLQLTAQS QVQMKKQKVS 
TPSDYTLSFL KRQRKGL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Men1

Associated with

Other Information

Characterization of the mouse Men1 gene and its expression during development. PubMed ID: 9824159

Primary structure, gene expression and chromosomal mapping of rodent homologs of the MEN1 tumor suppressor gene. PubMed ID: 10524203

Studies of the murine homolog of the multiple endocrine neoplasia type 1 (MEN1) gene, men1. PubMed ID: 9893060

Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene. PubMed ID: 10341092

Structure and distribution of rat menin mRNA. PubMed ID: 10612420

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. PubMed ID: 9989505

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. PubMed ID: 11158604

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. PubMed ID: 16415155

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303