Details for: Mesp1

Gene ID: 17292

Symbol: Mesp1

Ensembl ID: ENSMUSG00000030544

Description: mesoderm posterior 1

Associated with

  • Cardiac atrium formation
    (GO:0003210)
  • Cardiac cell fate determination
    (GO:0060913)
  • Cardiac muscle cell differentiation
    (GO:0055007)
  • Cardiac vascular smooth muscle cell differentiation
    (GO:0060947)
  • Cardiac ventricle formation
    (GO:0003211)
  • Cardioblast anterior-lateral migration
    (GO:0003259)
  • Cardioblast migration
    (GO:0003260)
  • Cardioblast migration to the midline involved in heart field formation
    (GO:0060975)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic heart tube morphogenesis
    (GO:0003143)
  • Endothelial cell differentiation
    (GO:0045446)
  • Gastrulation
    (GO:0007369)
  • Gene expression
    (GO:0010467)
  • Growth involved in heart morphogenesis
    (GO:0003241)
  • Heart induction
    (GO:0003129)
  • Heart looping
    (GO:0001947)
  • Heart morphogenesis
    (GO:0003007)
  • Lateral mesoderm development
    (GO:0048368)
  • Mesodermal cell migration
    (GO:0008078)
  • Mesoderm formation
    (GO:0001707)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of endodermal cell fate specification
    (GO:0042664)
  • Negative regulation of mesodermal cell fate specification
    (GO:0042662)
  • Neurogenesis
    (GO:0022008)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of hepatocyte differentiation
    (GO:0070368)
  • Positive regulation of notch signaling pathway
    (GO:0045747)
  • Positive regulation of striated muscle cell differentiation
    (GO:0051155)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Secondary heart field specification
    (GO:0003139)
  • Signal transduction involved in regulation of gene expression
    (GO:0023019)
  • Sinoatrial node cell differentiation
    (GO:0060921)
  • Sinus venosus morphogenesis
    (GO:0003236)
  • Somite rostral/caudal axis specification
    (GO:0032525)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Other Information

Genular Protein ID: 3258836183

Symbol: MESP1_MOUSE

Name: Mesoderm posterior protein 1

UniProtKB Accession Codes:

P97309 Q059W2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 1 GO 45 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 8787751

Title: MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation.

PubMed ID: 8787751

DOI: 10.1242/dev.122.9.2769

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10887078

Title: MesP1 and MesP2 are essential for the development of cardiac mesoderm.

PubMed ID: 10887078

DOI: 10.1242/dev.127.15.3215

PubMed ID: 15677726

Title: Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites.

PubMed ID: 15677726

DOI: 10.1242/dev.01597

PubMed ID: 17306789

Title: Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation.

PubMed ID: 17306789

DOI: 10.1016/j.ydbio.2007.01.007

Sequence Information:

  • Length: 243
  • Mass: 26386
  • Checksum: D82F72C0B0FB05EE
  • Sequence:
    • MAQPLCEPRS ESWILSPAGR QPPMPSDGNS VCSPAWSSDP WDGAQASSPA PPCARPARRA 
GTPGRRGTHG SRLGSGQRQS ASEREKLRMR TLARALHELR RFLPPSVAPT GQNLTKIETL 
RLAIRYIGHL SAVLGLSEDN LRRQRHAVSP RGCPLCPDSD LAQSQSLGPR LSPAVCSGVS 
WGSPPAYPRP RVAAESWDPS FLYAETASQE RQEMEPSPSS PLFSSDMLAL LETWTPPQEW 
PPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.