Details for: Mesp2

Gene ID: 17293

Symbol: Mesp2

Ensembl ID: ENSMUSG00000030543

Description: mesoderm posterior 2

Associated with

  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Heart morphogenesis
    (GO:0003007)
  • Mesodermal cell migration
    (GO:0008078)
  • Mesoderm formation
    (GO:0001707)
  • Multicellular organism development
    (GO:0007275)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Signal transduction involved in regulation of gene expression
    (GO:0023019)
  • Somite rostral/caudal axis specification
    (GO:0032525)
  • Somitogenesis
    (GO:0001756)

Other Information

Genular Protein ID: 2881677805

Symbol: MESP2_MOUSE

Name: Mesoderm posterior protein 2

UniProtKB Accession Codes:

O08574 Q3UIV5

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 17 Gene3D 1 InParanoid 1 InterPro 3 KEGG 1 MGI 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9242490

Title: Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.

PubMed ID: 9242490

DOI: 10.1101/gad.11.14.1827

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10330372

Title: Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse.

PubMed ID: 10330372

DOI: 10.1016/s0960-9822(99)80212-7

PubMed ID: 10887078

Title: MesP1 and MesP2 are essential for the development of cardiac mesoderm.

PubMed ID: 10887078

DOI: 10.1242/dev.127.15.3215

PubMed ID: 10932180

Title: Mesp2 initiates somite segmentation through the Notch signalling pathway.

PubMed ID: 10932180

DOI: 10.1038/78062

PubMed ID: 11562355

Title: The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis.

PubMed ID: 11562355

DOI: 10.1101/gad.907301

PubMed ID: 12900443

Title: Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites.

PubMed ID: 12900443

DOI: 10.1242/dev.00629

PubMed ID: 12591245

Title: The protocadherin papc is involved in the organization of the epithelium along the segmental border during mouse somitogenesis.

PubMed ID: 12591245

DOI: 10.1016/s0012-1606(02)00085-4

PubMed ID: 15677726

Title: Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites.

PubMed ID: 15677726

DOI: 10.1242/dev.01597

PubMed ID: 15902259

Title: The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity.

PubMed ID: 15902259

DOI: 10.1038/nature03591

PubMed ID: 16728472

Title: Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2.

PubMed ID: 16728472

DOI: 10.1242/dev.02422

PubMed ID: 16996494

Title: Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis.

PubMed ID: 16996494

DOI: 10.1016/j.ydbio.2006.08.043

PubMed ID: 16505380

Title: Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression.

PubMed ID: 16505380

DOI: 10.1073/pnas.0508238103

PubMed ID: 17360776

Title: The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite.

PubMed ID: 17360776

DOI: 10.1242/dev.000836

PubMed ID: 17306789

Title: Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation.

PubMed ID: 17306789

DOI: 10.1016/j.ydbio.2007.01.007

PubMed ID: 17477400

Title: Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation.

PubMed ID: 17477400

DOI: 10.1002/dvdy.21178

Sequence Information:

  • Length: 370
  • Mass: 39789
  • Checksum: 31CAB72E2398150D
  • Sequence:
    • MAQSSPPQSL QGLVPLGLLP GLGLGSAIGL HVSGLVLRFV RFLPFYATRR PSQPAGPARS 
TRTTQATAPR RTRPAPAGGQ RQSASEREKL RMRTLARALQ ELRRFLPPSV APAGQSLTKI 
ETLRLAIRYI GHLSALLGLS EDSLRRRRRR SADAAFSHRC PQCPDGGSPS QAQMLGPSLG 
SAMSSGVSWG CPPACPGPLI SPENLGNRIS NVDPRVTPPY CPQIQSPLHQ SLERAADSSP 
WAPPQACPGM QMSPEPRNKT GHWTQSTEPA ELTKVYQSLS VSPEPRLSLG SPLLLPRPSC 
QRLQPQPQPQ PQWGCWGHDA EVLSTSEDQG SSPALQLPVA SPTPSSGLQL SGCPELWQED 
LEGPPLNIFY

Genular Protein ID: 74570848

Symbol: A6H5V4_MOUSE

Name: N/A

UniProtKB Accession Codes:

A6H5V4

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 3 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HOGENOM 1 InterPro 3 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PaxDb 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 370
  • Mass: 39836
  • Checksum: BF48437113680033
  • Sequence:
    • MAQSPPPQSL QGLDHWVFSQ GWGWAQQSDS TSPASSSDSS GSCPCYATRR PSQPAGPARS 
TRTTQATAPR RTRPAPAGGQ RQSASEREKL RMRTLARALQ ELRRFLPPSV APAGQSLTKI 
ETLRLAIRYI GHLSALLGLS EDSLRRRRRR SADAAFSHRC PQCPDGGSPS QAQMLGPSLG 
SAMSSGVSWG CPPACPGPLI SPENLGNRIS NVDPWVTPPY CPQIQSPLHQ SLERAADSSP 
WAPPQACPGM QMSPEPRNKT GHWTQSTEPA ELTKVYQSLS VSPEPCLSLG SPLLLPRPSC 
QRLQPQPQPQ PQWGCWGHDA EVLSTSEDQG SSPALQLPVA SPTPSSGLQL SGCPELWQED 
LEGPPLNIFY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.