Details for: Foxc1

Gene ID: 17300

Symbol: Foxc1

Ensembl ID: ENSMUSG00000050295

Description: forkhead box C1

Associated with

Other Information

Genular Protein ID: 3520296922

Symbol: FOXC1_MOUSE

Name: Forkhead box protein C1

UniProtKB Accession Codes:

Q61572 O88409 Q61582 Q9QWR9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 Ensembl 1 GO 78 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9635428

Title: The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus.

PubMed ID: 9635428

DOI: 10.1016/s0092-8674(00)81204-0

PubMed ID: 9767123

Title: The mouse Fkh1/Mf1 gene: cDNA sequence, chromosomal localization and expression in adult tissues.

PubMed ID: 9767123

DOI: 10.1016/s0378-1119(98)00409-0

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7689224

Title: Six members of the mouse forkhead gene family are developmentally regulated.

PubMed ID: 7689224

DOI: 10.1073/pnas.90.16.7628

PubMed ID: 8375339

Title: Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo.

PubMed ID: 8375339

DOI: 10.1242/dev.118.1.47

PubMed ID: 9106663

Title: The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo.

PubMed ID: 9106663

DOI: 10.1101/gad.11.7.926

PubMed ID: 10395790

Title: The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye.

PubMed ID: 10395790

DOI: 10.1006/dbio.1999.9314

PubMed ID: 10479458

Title: Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles.

PubMed ID: 10479458

DOI: 10.1006/dbio.1999.9382

PubMed ID: 10704385

Title: Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract.

PubMed ID: 10704385

DOI: 10.1242/dev.127.7.1387

PubMed ID: 11562355

Title: The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis.

PubMed ID: 11562355

DOI: 10.1101/gad.907301

PubMed ID: 15196959

Title: The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.

PubMed ID: 15196959

DOI: 10.1016/j.ydbio.2004.03.034

PubMed ID: 16449236

Title: Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis.

PubMed ID: 16449236

DOI: 10.1093/hmg/ddl008

PubMed ID: 18187037

Title: Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration.

PubMed ID: 18187037

DOI: 10.1016/j.bbrc.2007.12.183

PubMed ID: 19668217

Title: FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation.

PubMed ID: 19668217

DOI: 10.1038/ng.422

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22493429

Title: Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2.

PubMed ID: 22493429

DOI: 10.1074/jbc.m112.339424

PubMed ID: 22171010

Title: Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth.

PubMed ID: 22171010

DOI: 10.1073/pnas.1109540109

PubMed ID: 24590069

Title: Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation.

PubMed ID: 24590069

DOI: 10.1038/nature13071

PubMed ID: 26565916

Title: FOXC1 activates smoothened-independent Hedgehog signaling in basal-like breast cancer.

PubMed ID: 26565916

DOI: 10.1016/j.celrep.2015.09.063

PubMed ID: 25808752

Title: The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification.

PubMed ID: 25808752

DOI: 10.1038/ncomms7653

PubMed ID: 28223138

Title: Foxc1 and Foxc2 are necessary to maintain glomerular podocytes.

PubMed ID: 28223138

DOI: 10.1016/j.yexcr.2017.02.016

Sequence Information:

  • Length: 553
  • Mass: 56940
  • Checksum: 3CDB14F69AA2F217
  • Sequence:
    • MQARYSVSSP NSLGVVPYLG GEQSYYRAAA AAAGGGYTAM PAPMSVYSHP AHAEQYPGSM 
ARAYGPYTPQ PQPKDMVKPP YSYIALITMA IQNAPDKKIT LNGIYQFIMD RFPFYRDNKQ 
GWQNSIRHNL SLNECFVKVP RDDKKPGKGS YWTLDPDSYN MFENGSFLRR RRRFKKKDAV 
KDKEEKGRLH LQEPPPPQAG RQPAPAPPEQ AEGSAPGPQP PPVRIQDIKT ENGTCPSPPQ 
PLSPAAALGS GSAATVPKIE SPDSSSSSLS SGSSPPGSLP SARPLSLDAA EPAPPPQPAP 
PPHHSQGFSV DNIMTSLRGS PQGSAAELGS GLLASAAASS RAGIAPPLAL GAYSPGQSSL 
YSSPCSQSSS AGSSGGGGGG GGGGGGSSSA AGTGGAATYH CNLQAMSLYA AGERGGHLQG 
PAGGAGSAAV DDPLPDYSLP PATSSSSSSL SHGGGGQEAS HHPASHQGRL TSWYLNQAGG 
DLGHLASAAA AAAAAGYPGQ QQNFHSVREM FESQRIGLNN SPVNGNSSCQ MAFPASQSLY 
RTSGAFVYDC SKF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.