Genular: Defining Cellular Identity and Function

Details for: Kitl

Gene ID: 17311

Symbol: Kitl

Ensembl ID: ENSMUSG00000019966

Description: kit ligand

Associated with

Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of kit signaling
(R-MMU-1433559)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by scf-kit
(R-MMU-1433557)
Signal transduction
(R-MMU-162582)
Apoptotic process
(GO:0006915)
Cell adhesion
(GO:0007155)
Cell population proliferation
(GO:0008283)
Cell projection
(GO:0042995)
Cytokine activity
(GO:0005125)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Ectopic germ cell programmed cell death
(GO:0035234)
Embryonic hemopoiesis
(GO:0035162)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Filopodium
(GO:0030175)
Germ cell development
(GO:0007281)
Growth factor activity
(GO:0008083)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Lamellipodium
(GO:0030027)
Mast cell apoptotic process
(GO:0033024)
Mast cell migration
(GO:0097531)
Mast cell proliferation
(GO:0070662)
Melanocyte migration
(GO:0097324)
Membrane
(GO:0016020)
Myeloid leukocyte differentiation
(GO:0002573)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of mast cell apoptotic process
(GO:0033026)
Neural crest cell migration
(GO:0001755)
Ovarian follicle development
(GO:0001541)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of hematopoietic progenitor cell differentiation
(GO:1901534)
Positive regulation of hematopoietic stem cell proliferation
(GO:1902035)
Positive regulation of leukocyte migration
(GO:0002687)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of mast cell proliferation
(GO:0070668)
Positive regulation of melanocyte differentiation
(GO:0045636)
Positive regulation of myeloid leukocyte differentiation
(GO:0002763)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of ras protein signal transduction
(GO:0046579)
Positive regulation of t cell proliferation
(GO:0042102)
Protein binding
(GO:0005515)
Ras protein signal transduction
(GO:0007265)
Stem cell factor receptor binding
(GO:0005173)
T cell proliferation
(GO:0042098)

Other Information

Proteins

Kit ligand

Genular Protein ID: 322389144

Symbol: SCF_MOUSE

Name: Kit ligand

UniProtKB Accession Codes:

P20826 P97332 Q3TNJ7 Q62524 Q64222 Q921N5

Database IDs:

Citations:

PubMed ID: 1698558

Title: Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms.

PubMed ID: 1698558

DOI: 10.1016/0092-8674(90)90304-w

PubMed ID: 1378327

Title: Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.

PubMed ID: 1378327

DOI: 10.1091/mbc.3.3.349

PubMed ID: 1705866

Title: Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.

PubMed ID: 1705866

DOI: 10.1016/0092-8674(91)90326-t

PubMed ID: 1383087

Title: Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.

PubMed ID: 1383087

DOI: 10.1101/gad.6.10.1832

PubMed ID: 8849898

Title: Multiple pathways for Steel regulation suggested by genomic and sequence analysis of the murine Steel gene.

PubMed ID: 8849898

DOI: 10.1093/genetics/142.3.927

PubMed ID: 8875893

Title: Molecular analysis of two new Steel mutations in mice shows a transversion or an insertion.

PubMed ID: 8875893

DOI: 10.1007/s003359900247

PubMed ID: 9360640

Title: Detection of a point mutation (A to G) in exon 5 of the murine Mgf gene defines a novel allele at the Steel locus with a weak phenotype.

PubMed ID: 9360640

DOI: 10.1016/s1383-5726(97)00005-8

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1698557

Title: The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.

PubMed ID: 1698557

DOI: 10.1016/0092-8674(90)90303-v

PubMed ID: 1698556

Title: Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor.

PubMed ID: 1698556

DOI: 10.1016/0092-8674(90)90302-u

PubMed ID: 1698554

Title: Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles.

PubMed ID: 1698554

DOI: 10.1016/0092-8674(90)90298-s

PubMed ID: 1698553

Title: Identification of a ligand for the c-kit proto-oncogene.

PubMed ID: 1698553

DOI: 10.1016/0092-8674(90)90297-r

PubMed ID: 26522471

Title: Allelic Mutations of KITLG, Encoding KIT Ligand, Cause Asymmetric and Unilateral Hearing Loss and Waardenburg Syndrome Type 2.

PubMed ID: 26522471

DOI: 10.1016/j.ajhg.2015.09.011

PubMed ID: 17255936

Title: Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases.

PubMed ID: 17255936

DOI: 10.1038/sj.emboj.7601545

Sequence Information:

Length: 273
Mass: 30645
Checksum: A7FC899B592A7967
Sequence:

MKKTQTWIIT CIYLQLLLFN PLVKTKEICG NPVTDNVKDI TKLVANLPND YMITLNYVAG 
MDVLPSHCWL RDMVIQLSLS LTTLLDKFSN ISEGLSNYSI IDKLGKIVDD LVLCMEENAP 
KNIKESPKRP ETRSFTPEEF FSIFNRSIDA FKDFMVASDT SDCVLSSTLG PEKDSRVSVT 
KPFMLPPVAA SSLRNDSSSS NRKAAKAPED SGLQWTAMAL PALISLVIGF AFGALYWKKK 
QSSLTRAVEN IQINEEDNEI SMLQQKEREF QEV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Kitl

Associated with

Other Information

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms. PubMed ID: 1698558

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2. PubMed ID: 1378327

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. PubMed ID: 1705866

Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail. PubMed ID: 1383087

Multiple pathways for Steel regulation suggested by genomic and sequence analysis of the murine Steel gene. PubMed ID: 8849898

Molecular analysis of two new Steel mutations in mice shows a transversion or an insertion. PubMed ID: 8875893

Detection of a point mutation (A to G) in exon 5 of the murine Mgf gene defines a novel allele at the Steel locus with a weak phenotype. PubMed ID: 9360640

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. PubMed ID: 1698557

Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. PubMed ID: 1698556

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles. PubMed ID: 1698554

Identification of a ligand for the c-kit proto-oncogene. PubMed ID: 1698553

Allelic Mutations of KITLG, Encoding KIT Ligand, Cause Asymmetric and Unilateral Hearing Loss and Waardenburg Syndrome Type 2. PubMed ID: 26522471

Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases. PubMed ID: 17255936