Details for: Mif

Gene ID: 17319

Symbol: Mif

Ensembl ID: ENSMUSG00000033307

Description: macrophage migration inhibitory factor (glycosylation-inhibiting factor)

Associated with

  • Cell surface interactions at the vascular wall
    (R-MMU-202733)
  • Hemostasis
    (R-MMU-109582)
  • Immune system
    (R-MMU-168256)
  • Innate immune system
    (R-MMU-168249)
  • Neutrophil degranulation
    (R-MMU-6798695)
  • Carboxylic acid metabolic process
    (GO:0019752)
  • Cell surface
    (GO:0009986)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular senescence
    (GO:0090398)
  • Chemoattractant activity
    (GO:0042056)
  • Cytokine activity
    (GO:0005125)
  • Cytokine receptor binding
    (GO:0005126)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Dna damage response, signal transduction by p53 class mediator
    (GO:0030330)
  • Dopachrome isomerase activity
    (GO:0004167)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Identical protein binding
    (GO:0042802)
  • Immune system process
    (GO:0002376)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Isomerase activity
    (GO:0016853)
  • Myelin sheath
    (GO:0043209)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cellular senescence
    (GO:2000773)
  • Negative regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043518)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:1902166)
  • Negative regulation of macrophage chemotaxis
    (GO:0010760)
  • Negative regulation of mature b cell apoptotic process
    (GO:0002906)
  • Negative regulation of myeloid cell apoptotic process
    (GO:0033033)
  • Negative regulation of protein metabolic process
    (GO:0051248)
  • Nucleoplasm
    (GO:0005654)
  • Phenylpyruvate tautomerase activity
    (GO:0050178)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of adaptive immune response
    (GO:0002821)
  • Positive regulation of arachidonic acid secretion
    (GO:0090238)
  • Positive regulation of b cell proliferation
    (GO:0030890)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of chemokine (c-x-c motif) ligand 2 production
    (GO:2000343)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of lipopolysaccharide-mediated signaling pathway
    (GO:0031666)
  • Positive regulation of map kinase activity
    (GO:0043406)
  • Positive regulation of myeloid leukocyte cytokine production involved in immune response
    (GO:0061081)
  • Positive regulation of peptidyl-serine phosphorylation
    (GO:0033138)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of phosphorylation
    (GO:0042327)
  • Positive regulation of prostaglandin secretion involved in immune response
    (GO:0061078)
  • Positive regulation of protein kinase a signaling
    (GO:0010739)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Prostaglandin biosynthetic process
    (GO:0001516)
  • Protease binding
    (GO:0002020)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein homotrimerization
    (GO:0070207)
  • Regulation of cell population proliferation
    (GO:0042127)

Other Information

Genular Protein ID: 841365600

Symbol: MIF_MOUSE

Name: Macrophage migration inhibitory factor

UniProtKB Accession Codes:

P34884

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CPTAC 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DNASU 1 EC 2 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 53 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 3 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8413654

Title: MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia.

PubMed ID: 8413654

DOI: 10.1038/365756a0

PubMed ID: 1508193

Title: Growth factor-induced delayed early response genes.

PubMed ID: 1508193

DOI: 10.1128/mcb.12.9.3919-3929.1992

PubMed ID: 8234256

Title: Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor.

PubMed ID: 8234256

DOI: 10.1073/pnas.90.21.10056

PubMed ID: 7706726

Title: Cloning and characterization of the gene for mouse macrophage migration inhibitory factor (MIF).

PubMed ID: 7706726

PubMed ID: 7558021

Title: Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes.

PubMed ID: 7558021

DOI: 10.1006/geno.1995.1071

PubMed ID: 7558020

Title: Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.

PubMed ID: 7558020

DOI: 10.1006/geno.1995.1070

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7679497

Title: A macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens.

PubMed ID: 7679497

DOI: 10.1073/pnas.90.4.1272

PubMed ID: 7947826

Title: Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF).

PubMed ID: 7947826

DOI: 10.1021/bi00251a025

PubMed ID: 17526494

Title: Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.

PubMed ID: 17526494

DOI: 10.1074/jbc.m701825200

PubMed ID: 19188446

Title: A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation.

PubMed ID: 19188446

DOI: 10.1128/mcb.01907-08

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 10360941

Title: Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition.

PubMed ID: 10360941

DOI: 10.1021/bi9904048

PubMed ID: 10933783

Title: Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the P1G, P1A, Y95F, and N97A mutants.

PubMed ID: 10933783

DOI: 10.1021/bi000373c

PubMed ID: 16780921

Title: Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate.

PubMed ID: 16780921

DOI: 10.1016/j.bioorg.2006.05.001

Sequence Information:

  • Length: 115
  • Mass: 12504
  • Checksum: 92D207B81B149945
  • Sequence:
    • MPMFIVNTNV PRASVPEGFL SELTQQLAQA TGKPAQYIAV HVVPDQLMTF SGTNDPCALC 
SLHSIGKIGG AQNRNYSKLL CGLLSDRLHI SPDRVYINYY DMNAANVGWN GSTFA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.