Genular: Defining Cellular Identity and Function

Details for: Mlh1

Gene ID: 17350

Symbol: Mlh1

Ensembl ID: ENSMUSG00000032498

Description: mutL homolog 1

Associated with

Mismatch repair (mmr) directed by msh2:msh6 (mutsalpha)
(R-MMU-5358565)
Atp-dependent dna damage sensor activity
(GO:0140664)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cell cycle
(GO:0007049)
Chiasma
(GO:0005712)
Chromatin binding
(GO:0003682)
Chromosome
(GO:0005694)
Condensed chromosome
(GO:0000793)
Condensed nuclear chromosome
(GO:0000794)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Double-strand break repair via nonhomologous end joining
(GO:0006303)
Enzyme binding
(GO:0019899)
Female meiosis chromosome segregation
(GO:0016321)
Guanine/thymine mispair binding
(GO:0032137)
Homologous chromosome pairing at meiosis
(GO:0007129)
Homologous chromosome segregation
(GO:0045143)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Isotype switching
(GO:0045190)
Late recombination nodule
(GO:0005715)
Leptotene
(GO:0000237)
Male germ cell nucleus
(GO:0001673)
Male meiosis chromosome segregation
(GO:0007060)
Male meiotic nuclear division
(GO:0007140)
Meiotic cell cycle
(GO:0051321)
Meiotic chromosome segregation
(GO:0045132)
Meiotic metaphase i homologous chromosome alignment
(GO:0043060)
Meiotic spindle midzone assembly
(GO:0051257)
Meiotic telomere clustering
(GO:0045141)
Mismatched dna binding
(GO:0030983)
Mismatch repair
(GO:0006298)
Mismatch repair complex
(GO:0032300)
Mutlalpha complex
(GO:0032389)
Mutsalpha complex binding
(GO:0032407)
Negative regulation of mitotic recombination
(GO:0045950)
Nuclear-transcribed mrna poly(a) tail shortening
(GO:0000289)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Oogenesis
(GO:0048477)
Positive regulation of isotype switching to iga isotypes
(GO:0048298)
Positive regulation of isotype switching to igg isotypes
(GO:0048304)
Reciprocal meiotic recombination
(GO:0007131)
Resolution of meiotic recombination intermediates
(GO:0000712)
Response to bacterium
(GO:0009617)
Single-stranded dna binding
(GO:0003697)
Somatic hypermutation of immunoglobulin genes
(GO:0016446)
Somatic recombination of immunoglobulin gene segments
(GO:0016447)
Somatic recombination of immunoglobulin genes involved in immune response
(GO:0002204)
Spermatogenesis
(GO:0007283)
Synaptonemal complex
(GO:0000795)

Other Information

Proteins

DNA mismatch repair protein Mlh1

Genular Protein ID: 3120435525

Symbol: MLH1_MOUSE

Name: DNA mismatch repair protein Mlh1

UniProtKB Accession Codes:

Q9JK91 Q3TG77 Q62454

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 8674118

Title: Meiotic pachytene arrest in MLH1-deficient mice.

PubMed ID: 8674118

DOI: 10.1016/s0092-8674(00)81312-4

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 30949703

Title: SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.

PubMed ID: 30949703

DOI: 10.1093/nar/gkz226

Sequence Information:

Length: 760
Mass: 84670
Checksum: B789D812F497FDF7
Sequence:

MAFVAGVIRR LDETVVNRIA AGEVIQRPAN AIKEMIENCL DAKSTNIQVV VKEGGLKLIQ 
IQDNGTGIRK EDLDIVCERF TTSKLQTFED LASISTYGFR GEALASISHV AHVTITTKTA 
DGKCAYRASY SDGKLQAPPK PCAGNQGTLI TVEDLFYNII TRRKALKNPS EEYGKILEVV 
GRYSIHNSGI SFSVKKQGET VSDVRTLPNA TTVDNIRSIF GNAVSRELIE VGCEDKTLAF 
KMNGYISNAN YSVKKCIFLL FINHRLVESA ALRKAIETVY AAYLPKNTHP FLYLSLEISP 
QNVDVNVHPT KHEVHFLHEE SILQRVQQHI ESKLLGSNSS RMYFTQTLLP GLAGPSGEAA 
RPTTGVASSS TSGSGDKVYA YQMVRTDSRE QKLDAFLQPV SSLGPSQPQD PAPVRGARTE 
GSPERATRED EEMLALPAPA EAAAESENLE RESLMETSDA AQKAAPTSSP GSSRKRHRED 
SDVEMVENAS GKEMTAACYP RRRIINLTSV LSLQEEISER CHETLREMLR NHSFVGCVNP 
QWALAQHQTK LYLLNTTKLS EELFYQILIY DFANFGVLRL SEPAPLFDLA MLALDSPESG 
WTEDDGPKEG LAEYIVEFLK KKAEMLADYF SVEIDEEGNL IGLPLLIDSY VPPLEGLPIF 
ILRLATEVNW DEEKECFESL SKECAMFYSI RKQYILEEST LSGQQSDMPG STSKPWKWTV 
EHIIYKAFRS HLLPPKHFTE DGNVLQLANL PDLYKVFERC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mlh1

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Meiotic pachytene arrest in MLH1-deficient mice. PubMed ID: 8674118

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice. PubMed ID: 30949703

Database document:

PubMed ID: 16141072

PubMed ID: 8674118

PubMed ID: 21183079

PubMed ID: 30949703