Genular: Defining Cellular Identity and Function

Details for: Mme

Gene ID: 17380

Symbol: Mme

Ensembl ID: ENSMUSG00000027820

Description: membrane metallo endopeptidase

Associated with

Cardiac conduction
(R-MMU-5576891)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism of angiotensinogen to angiotensins
(R-MMU-2022377)
Metabolism of proteins
(R-MMU-392499)
Muscle contraction
(R-MMU-397014)
Neutrophil degranulation
(R-MMU-6798695)
Peptide hormone metabolism
(R-MMU-2980736)
Physiological factors
(R-MMU-5578768)
Amyloid-beta clearance
(GO:0097242)
Amyloid-beta clearance by cellular catabolic process
(GO:0150094)
Amyloid-beta metabolic process
(GO:0050435)
Axon
(GO:0030424)
Bradykinin catabolic process
(GO:0010815)
Brush border
(GO:0005903)
Cardiolipin binding
(GO:1901612)
Cellular response to cytokine stimulus
(GO:0071345)
Cellular response to uv-a
(GO:0071492)
Cellular response to uv-b
(GO:0071493)
Creatinine metabolic process
(GO:0046449)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Dendrite
(GO:0030425)
Early endosome
(GO:0005769)
Endopeptidase activity
(GO:0004175)
Exopeptidase activity
(GO:0008238)
Hormone catabolic process
(GO:0042447)
Hydrolase activity
(GO:0016787)
Learning or memory
(GO:0007611)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Metalloendopeptidase activity
(GO:0004222)
Metallopeptidase activity
(GO:0008237)
Neuronal cell body
(GO:0043025)
Neuron projection terminus
(GO:0044306)
Neuropeptide processing
(GO:0061837)
Oligopeptidase activity
(GO:0070012)
Peptidase activity
(GO:0008233)
Peptide binding
(GO:0042277)
Peptide metabolic process
(GO:0006518)
Phosphatidylserine binding
(GO:0001786)
Plasma membrane
(GO:0005886)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Positive regulation of neurogenesis
(GO:0050769)
Presynapse
(GO:0098793)
Protein catabolic process
(GO:0030163)
Protein homodimerization activity
(GO:0042803)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Response to estrogen
(GO:0043627)
Sensory perception of pain
(GO:0019233)
Substance p catabolic process
(GO:0010814)
Synapse
(GO:0045202)
Synaptic vesicle
(GO:0008021)
Trans-golgi network
(GO:0005802)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Neprilysin

Genular Protein ID: 3375487545

Symbol: NEP_MOUSE

Name: Neprilysin

UniProtKB Accession Codes:

Q61391 Q6NXX5 Q8K251

Database IDs:

Citations:

PubMed ID: 1374101

Title: Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site.

PubMed ID: 1374101

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20876573

Title: Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses.

PubMed ID: 20876573

DOI: 10.1074/jbc.m110.161547

PubMed ID: 27588448

Title: Rare variants in MME, encoding metalloprotease neprilysin, are linked to late-onset autosomal-dominant axonal polyneuropathies.

PubMed ID: 27588448

DOI: 10.1016/j.ajhg.2016.07.008

Sequence Information:

Length: 750
Mass: 85702
Checksum: 1FC39A971D98F6FE
Sequence:

MGRSESQMDI TDINAPKPKK KQRWTPLEIS LSVLVLLLTI IAVTMIALYA TYDDGICKSS 
DCIKSAARLI QNMDASVEPC TDFFKYACGG WLKRNVIPET SSRYSNFDIL RDELEVILKD 
VLQEPKTEDI VAVQKAKTLY RSCINESAID SRGGQPLLKL LPDIYGWPVA SDNWDQTYGT 
SWTAEKSIAQ LNSKYGKKVL INFFVGTDDK NSTQHIIHFD QPRLGLPSRD YYECTGIYKE 
ACTAYVDFMI SVARLIRQEQ SLPIDENQLS LEMNKVMELE KEIANATTKP EDRNDPMLLY 
NKMTLAKLQN NFSLEVNGKS FSWSNFTNEI MSTVNINIQN EEEVVVYAPE YLTKLKPILT 
KYSPRDLQNL MSWRFIMDLV SSLSRNYKES RNAFRKALYG TTSETATWRR CANYVNGNME 
NAVGRLYVEA AFAGESKHVV EDLIAQIREV FIQTLDDLTW MDAETKKKAE EKALAIKERI 
GYPDDIISNE NKLNNEYLEL NYREDEYFEN IIQNLKFSQS KQLKKLREKV DKDEWISGAA 
VVNAFYSSGR NQIVFPAGIL QPPFFSAQQS NSLNYGGIGM VIGHEITHGF DDNGRNFNKD 
GDLVDWWTQQ SANNFKDQSQ CMVYQYGNFS WDLAGGQHLN GINTLGENIA DNGGIGQAYR 
AYQNYVKKNG EEKLLPGLDL NHKQLFFLNF AQVWCGTYRP EYAVNSIKTD VHSPGNFRII 
GTLQNSAEFA DAFHCRKNSY MNPERKCRVW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mme

Associated with

Other Information

Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site. PubMed ID: 1374101

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses. PubMed ID: 20876573

Rare variants in MME, encoding metalloprotease neprilysin, are linked to late-onset autosomal-dominant axonal polyneuropathies. PubMed ID: 27588448