Genular: Defining Cellular Identity and Function

Details for: Mmp12

Gene ID: 17381

Symbol: Mmp12

Ensembl ID: ENSMUSG00000049723

Description: matrix metallopeptidase 12

Associated with

Collagen degradation
(R-MMU-1442490)
Degradation of the extracellular matrix
(R-MMU-1474228)
Bronchiole development
(GO:0060435)
Calcium ion binding
(GO:0005509)
Cellular response to virus
(GO:0098586)
Collagen binding
(GO:0005518)
Collagen catabolic process
(GO:0030574)
Core promoter sequence-specific dna binding
(GO:0001046)
Cytoplasm
(GO:0005737)
Elastin catabolic process
(GO:0060309)
Extracellular matrix
(GO:0031012)
Extracellular matrix organization
(GO:0030198)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hydrolase activity
(GO:0016787)
Lung alveolus development
(GO:0048286)
Metal ion binding
(GO:0046872)
Metalloendopeptidase activity
(GO:0004222)
Metallopeptidase activity
(GO:0008237)
Negative regulation of endothelial cell-matrix adhesion via fibronectin
(GO:1904905)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of type i interferon-mediated signaling pathway
(GO:0060339)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Positive regulation of epithelial cell proliferation involved in wound healing
(GO:0060054)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of type i interferon-mediated signaling pathway
(GO:0060340)
Protein import into nucleus
(GO:0006606)
Proteolysis
(GO:0006508)
Regulation of defense response to virus by host
(GO:0050691)
Regulation of trophoblast cell migration
(GO:1901163)
Sequence-specific dna binding
(GO:0043565)
Wound healing, spreading of epidermal cells
(GO:0035313)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Macrophage metalloelastase
Q3TCW6_MOUSE

Genular Protein ID: 1223637482

Symbol: MMP12_MOUSE

Name: Macrophage metalloelastase

UniProtKB Accession Codes:

P34960 Q3TB28 Q3TBV6 Q3TBV9 Q3TD61 Q3U1S8 Q3U1S9 Q3U2R8 Q3UBC5 Q4FJM7 Q8BJ92 Q8BJB3 Q8BJB6 Q8BJB8 Q8BJB9 Q8VED6

Database IDs:

Citations:

PubMed ID: 1537850

Title: Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.

PubMed ID: 1537850

DOI: 10.1016/s0021-9258(18)42885-2

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 473
Mass: 54971
Checksum: D377250610BA249E
Sequence:

MSCTLLKGVC TMKFLMMIVF LQVSACGAAP MNDSEFAEWY LSRFYDYGKD RIPMTKTKTN 
RNFLKEKLQE MQQFFGLEAT GQLDNSTLAI MHIPRCGVPD VQHLRAVPQR SRWMKRYLTY 
RIYNYTPDMK REDVDYIFQK AFQVWSDVTP LRFRKLHKDE ADIMILFAFG AHGDFNYFDG 
KGGTLAHAFY PGPGIQGDAH FDEAETWTKS FQGTNLFLVA VHELGHSLGL QHSNNPKSIM 
YPTYRYLNPS TFRLSADDIR NIQSLYGAPV KPPSLTKPSS PPSTFCHQSL SFDAVTTVGE 
KIFFFKDWFF WWKLPGSPAT NITSISSIWP SIPSGIQAAY EIESRNQLFL FKDEKYWLIN 
NLVPEPHYPR SIYSLGFSAS VKKVDAAVFD PLRQKVYFFV DKHYWRYDVR QELMDPAYPK 
LISTHFPGIK PKIDAVLYFK RHYYIFQGAY QLEYDPLFRR VTKTLKSTSW FGC

Genular Protein ID: 1974382787

Symbol: Q3TCW6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TCW6

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 403
Mass: 46817
Checksum: 1F9F88E2EAD813D6
Sequence:

MQQFFGLEAT GQLDNSTLAI MHIPRCGVPD VQHLRAVPQR SRWMKRYLTY RIYNYTPDMK 
REDVDYIFQK AFQVWSDVTP LRFRKLHKDE ADIMILFAFG AHGDFNYFDG KGGTLAHAFY 
PGPGIQGDAH FDEAETWTKS FQGTNLFLVA VHELGHSLGL QHSNNPKSIM YPTYRYLNPS 
TFRLSADDIR NIQSLYGAPV KPPSLTKPSS PPSTFCHQSL SFDAVTTVGE KIFFFKDWFF 
WWKLPGSPAT NITSISSIWP SIPSGIQAAY EIESRNQLFL FKDEKYWLIN NLVPEPHYPR 
SIYSLGFSAS VKKVDAAVFD PLRQKVYFFV DKHYWRYDVR QELMDPAYPK LISTHFPGIK 
PKIDAVLYFK RHYYIFQGAY QLEYDPLFRR VTKTLKSTSW FGC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mmp12

Associated with

Other Information

Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase. PubMed ID: 1537850

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303