Genular: Defining Cellular Identity and Function

Details for: Mmp13

Gene ID: 17386

Symbol: Mmp13

Ensembl ID: ENSMUSG00000050578

Description: matrix metallopeptidase 13

Associated with

Activation of matrix metalloproteinases
(R-MMU-1592389)
Assembly of collagen fibrils and other multimeric structures
(R-MMU-2022090)
Collagen degradation
(R-MMU-1442490)
Collagen formation
(R-MMU-1474290)
Degradation of the extracellular matrix
(R-MMU-1474228)
Bone mineralization
(GO:0030282)
Bone morphogenesis
(GO:0060349)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion binding
(GO:0005509)
Collagen binding
(GO:0005518)
Collagen catabolic process
(GO:0030574)
Endochondral ossification
(GO:0001958)
Endopeptidase activity
(GO:0004175)
Extracellular matrix
(GO:0031012)
Extracellular matrix disassembly
(GO:0022617)
Extracellular matrix organization
(GO:0030198)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibronectin binding
(GO:0001968)
Growth plate cartilage development
(GO:0003417)
Heart development
(GO:0007507)
Hydrolase activity
(GO:0016787)
Intercellular canaliculus
(GO:0046581)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Metal ion binding
(GO:0046872)
Metalloendopeptidase activity
(GO:0004222)
Metallopeptidase activity
(GO:0008237)
Peptidase activity
(GO:0008233)
Positive regulation of pancreatic trypsinogen secretion
(GO:1904244)
Protein catabolic process
(GO:0030163)
Protein metabolic process
(GO:0019538)
Proteolysis
(GO:0006508)
Response to hormone
(GO:0009725)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Collagenase 3

Genular Protein ID: 1761115316

Symbol: MMP13_MOUSE

Name: Collagenase 3

UniProtKB Accession Codes:

P33435

Database IDs:

Citations:

PubMed ID: 1383028

Title: Cloning and sequencing of mouse collagenase cDNA. Divergence of mouse and rat collagenases from the other mammalian collagenases.

PubMed ID: 1383028

DOI: 10.1016/0014-5793(92)81323-e

PubMed ID: 15539485

Title: Altered endochondral bone development in matrix metalloproteinase 13-deficient mice.

PubMed ID: 15539485

DOI: 10.1242/dev.01461

PubMed ID: 15563592

Title: Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.

PubMed ID: 15563592

DOI: 10.1073/pnas.0407788101

PubMed ID: 17987127

Title: Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration.

PubMed ID: 17987127

DOI: 10.1371/journal.pone.0001150

PubMed ID: 19590036

Title: MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing.

PubMed ID: 19590036

DOI: 10.2353/ajpath.2009.081080

PubMed ID: 22880047

Title: MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability.

PubMed ID: 22880047

DOI: 10.1371/journal.pone.0042596

PubMed ID: 10525409

Title: Structure of recombinant mouse collagenase-3 (MMP-13).

PubMed ID: 10525409

DOI: 10.1006/jmbi.1999.3068

Sequence Information:

Length: 472
Mass: 54182
Checksum: 67F437B89B4D0DBD
Sequence:

MHSAILATFF LLSWTPCWSL PLPYGDDDDD DLSEEDLVFA EHYLKSYYHP ATLAGILKKS 
TVTSTVDRLR EMQSFFGLEV TGKLDDPTLD IMRKPRCGVP DVGEYNVFPR TLKWSQTNLT 
YRIVNYTPDM SHSEVEKAFR KAFKVWSDVT PLNFTRIYDG TADIMISFGT KEHGDFYPFD 
GPSGLLAHAF PPGPNYGGDA HFDDDETWTS SSKGYNLFIV AAHELGHSLG LDHSKDPGAL 
MFPIYTYTGK SHFMLPDDDV QGIQFLYGPG DEDPNPKHPK TPEKCDPALS LDAITSLRGE 
TMIFKDRFFW RLHPQQVEAE LFLTKSFWPE LPNHVDAAYE HPSRDLMFIF RGRKFWALNG 
YDILEGYPRK ISDLGFPKEV KRLSAAVHFE NTGKTLFFSE NHVWSYDDVN QTMDKDYPRL 
IEEEFPGIGN KVDAVYEKNG YIYFFNGPIQ FEYSIWSNRI VRVMPTNSIL WC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mmp13

Associated with

Other Information

Cloning and sequencing of mouse collagenase cDNA. Divergence of mouse and rat collagenases from the other mammalian collagenases. PubMed ID: 1383028

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. PubMed ID: 15539485

Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. PubMed ID: 15563592

Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. PubMed ID: 17987127

MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing. PubMed ID: 19590036

MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability. PubMed ID: 22880047

Structure of recombinant mouse collagenase-3 (MMP-13). PubMed ID: 10525409