Genular: Defining Cellular Identity and Function

Details for: Mmp14

Gene ID: 17387

Symbol: Mmp14

Ensembl ID: ENSMUSG00000000957

Description: matrix metallopeptidase 14 (membrane-inserted)

Associated with

Activation of matrix metalloproteinases
(R-MMU-1592389)
Collagen degradation
(R-MMU-1442490)
Degradation of the extracellular matrix
(R-MMU-1474228)
Bone development
(GO:0060348)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Cell migration
(GO:0016477)
Chondrocyte proliferation
(GO:0035988)
Collagen catabolic process
(GO:0030574)
Craniofacial suture morphogenesis
(GO:0097094)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Embryonic cranial skeleton morphogenesis
(GO:0048701)
Endochondral ossification
(GO:0001958)
Endopeptidase activity
(GO:0004175)
Extracellular matrix
(GO:0031012)
Extracellular matrix organization
(GO:0030198)
Extracellular space
(GO:0005615)
Head development
(GO:0060322)
Hydrolase activity
(GO:0016787)
Integrin binding
(GO:0005178)
Intermediate filament cytoskeleton
(GO:0045111)
Lung development
(GO:0030324)
Macropinosome
(GO:0044354)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Metalloaminopeptidase activity
(GO:0070006)
Metalloendopeptidase activity
(GO:0004222)
Metallopeptidase activity
(GO:0008237)
Negative regulation of focal adhesion assembly
(GO:0051895)
Negative regulation of notch signaling pathway
(GO:0045746)
Nucleus
(GO:0005634)
Ossification
(GO:0001503)
Peptidase activity
(GO:0008233)
Plasma membrane
(GO:0005886)
Positive regulation of b cell differentiation
(GO:0045579)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of macrophage migration
(GO:1905523)
Positive regulation of myotube differentiation
(GO:0010831)
Positive regulation of protein processing
(GO:0010954)
Proteolysis
(GO:0006508)
Regulation of protein localization to plasma membrane
(GO:1903076)
Response to hormone
(GO:0009725)
Skeletal system development
(GO:0001501)
Tissue remodeling
(GO:0048771)
Zinc ion binding
(GO:0008270)
Zymogen activation
(GO:0031638)

Other Information

Proteins

Matrix metalloproteinase-14

Genular Protein ID: 2714278689

Symbol: MMP14_MOUSE

Name: Matrix metalloproteinase-14

UniProtKB Accession Codes:

P53690 O08645 O35369 Q8BTX2

Database IDs:

Citations:

PubMed ID: 7708715

Title: Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.

PubMed ID: 7708715

DOI: 10.1073/pnas.92.7.2730

PubMed ID: 9325265

Title: The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis.

PubMed ID: 9325265

DOI: 10.1074/jbc.272.41.25511

PubMed ID: 9648071

Title: Cloning of murine membrane-type-1-matrix metalloproteinase (MT-1-MMP) and its metanephric developmental regulation with respect to MMP-2 and its inhibitor.

PubMed ID: 9648071

DOI: 10.1046/j.1523-1755.1998.00xxx.x

PubMed ID: 16778201

Title: Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice.

PubMed ID: 16778201

DOI: 10.1158/0008-5472.can-06-0539

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10520996

Title: MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover.

PubMed ID: 10520996

DOI: 10.1016/s0092-8674(00)80064-1

Sequence Information:

Length: 582
Mass: 65919
Checksum: 6CA95CFD5811B093
Sequence:

MSPAPRPSRS LLLPLLTLGT ALASLGWAQG SNFSPEAWLQ QYGYLPPGDL RTHTQRSPQS 
LSAAIAAMQK FYGLQVTGKA DLATMMAMRR PRCGVPDKFG TEIKANVRRK RYAIQGLKWQ 
HNEITFCIQN YTPKVGEYAT FEAIRKAFRV WESATPLRFR EVPYAYIREG HEKQADIMIL 
FAEGFHGDST PFDGEGGFLA HAYFPGPNIG GDTHFDSAEP WTVQNEDLNG NDIFLVAVHE 
LGHALGLEHS NDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYGSKSGSP TKMPPQPRTT 
SRPSVPDKPK NPAYGPNICD GNFDTVAMLR GEMFVFKERW FWRVRNNQVM DGYPMPIGQF 
WRGLPASINT AYERKDGKFV FFKGDKHWVF DEASLEPGYP KHIKELGRGL PTDKIDAALF 
WMPNGKTYFF RGNKYYRFNE EFRAVDSEYP KNIKVWEGIP ESPRGSFMGS DEVFTYFYKG 
NKYWKFNNQK LKVEPGYPKS ALRDWMGCPS GGRPDEGTEE ETEVIIIEVD EEGSGAVSAA 
AVVLPVLLLL LVLAVGLAVF FFRRHGTPKR LLYCQRSLLD KV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mmp14

Associated with

Other Information

Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. PubMed ID: 7708715

The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis. PubMed ID: 9325265

Cloning of murine membrane-type-1-matrix metalloproteinase (MT-1-MMP) and its metanephric developmental regulation with respect to MMP-2 and its inhibitor. PubMed ID: 9648071

Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice. PubMed ID: 16778201

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072