Genular: Defining Cellular Identity and Function

Details for: Mmp2

Gene ID: 17390

Symbol: Mmp2

Ensembl ID: ENSMUSG00000031740

Description: matrix metallopeptidase 2

Associated with

Activation of matrix metalloproteinases
(R-MMU-1592389)
Axon guidance
(R-MMU-422475)
Collagen degradation
(R-MMU-1442490)
Degradation of the extracellular matrix
(R-MMU-1474228)
Developmental biology
(R-MMU-1266738)
Eph-ephrin mediated repulsion of cells
(R-MMU-3928665)
Eph-ephrin signaling
(R-MMU-2682334)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Nervous system development
(R-MMU-9675108)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
Angiogenesis
(GO:0001525)
Blood vessel maturation
(GO:0001955)
Bone trabecula formation
(GO:0060346)
Cell migration
(GO:0016477)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to estradiol stimulus
(GO:0071392)
Cellular response to reactive oxygen species
(GO:0034614)
Cellular response to uv-a
(GO:0071492)
Collagen catabolic process
(GO:0030574)
Embryo implantation
(GO:0007566)
Endopeptidase activity
(GO:0004175)
Extracellular matrix
(GO:0031012)
Extracellular matrix organization
(GO:0030198)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Face morphogenesis
(GO:0060325)
Fibronectin binding
(GO:0001968)
Heart development
(GO:0007507)
Hydrolase activity
(GO:0016787)
Intramembranous ossification
(GO:0001957)
Macrophage chemotaxis
(GO:0048246)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Metalloendopeptidase activity
(GO:0004222)
Metallopeptidase activity
(GO:0008237)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of vasoconstriction
(GO:0045906)
Nucleus
(GO:0005634)
Ovarian follicle development
(GO:0001541)
Peptidase activity
(GO:0008233)
Peripheral nervous system axon regeneration
(GO:0014012)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
(GO:1903378)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of vascular associated smooth muscle cell proliferation
(GO:1904707)
Prostate gland epithelium morphogenesis
(GO:0060740)
Protein catabolic process
(GO:0030163)
Proteolysis
(GO:0006508)
Response to amyloid-beta
(GO:1904645)
Response to estrogen
(GO:0043627)
Response to hydrogen peroxide
(GO:0042542)
Response to hypoxia
(GO:0001666)
Response to mechanical stimulus
(GO:0009612)
Response to oxidative stress
(GO:0006979)
Response to xenobiotic stimulus
(GO:0009410)
Sarcomere
(GO:0030017)
Serine-type endopeptidase activity
(GO:0004252)
Skeletal system morphogenesis
(GO:0048705)
Tissue remodeling
(GO:0048771)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

72 kDa type IV collagenase

Genular Protein ID: 3653446850

Symbol: MMP2_MOUSE

Name: 72 kDa type IV collagenase

UniProtKB Accession Codes:

P33434

Database IDs:

Citations:

PubMed ID: 1373140

Title: Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development.

PubMed ID: 1373140

DOI: 10.1016/s0021-9258(18)42592-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2744464

Title: Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development.

PubMed ID: 2744464

DOI: 10.1101/gad.3.6.848

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22509276

Title: A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity.

PubMed ID: 22509276

DOI: 10.1371/journal.pone.0034177

Sequence Information:

Length: 662
Mass: 74102
Checksum: C630A7DBDB272F02
Sequence:

MEARVAWGAL AGPLRVLCVL CCLLGRAIAA PSPIIKFPGD VAPKTDKELA VQYLNTFYGC 
PKESCNLFVL KDTLKKMQKF FGLPQTGDLD QNTIETMRKP RCGNPDVANY NFFPRKPKWD 
KNQITYRIIG YTPDLDPETV DDAFARALKV WSDVTPLRFS RIHDGEADIM INFGRWEHGD 
GYPFDGKDGL LAHAFAPGTG VGGDSHFDDD ELWTLGEGQV VRVKYGNADG EYCKFPFLFN 
GREYSSCTDT GRSDGFLWCS TTYNFEKDGK YGFCPHEALF TMGGNADGQP CKFPFRFQGT 
SYNSCTTEGR TDGYRWCGTT EDYDRDKKYG FCPETAMSTV GGNSEGAPCV FPFTFLGNKY 
ESCTSAGRND GKVWCATTTN YDDDRKWGFC PDQGYSLFLV AAHEFGHAMG LEHSQDPGAL 
MAPIYTYTKN FRLSHDDIKG IQELYGPSPD ADTDTGTGPT PTLGPVTPEI CKQDIVFDGI 
AQIRGEIFFF KDRFIWRTVT PRDKPTGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN 
EYWVYSASTL ERGYPKPLTS LGLPPDVQQV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM 
DPGFPKLIAD SWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL 
GC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mmp2

Associated with

Other Information

Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development. PubMed ID: 1373140

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development. PubMed ID: 2744464