Genular: Defining Cellular Identity and Function

Details for: Mmp9

Gene ID: 17395

Symbol: Mmp9

Ensembl ID: ENSMUSG00000017737

Description: matrix metallopeptidase 9

Associated with

Activation of matrix metalloproteinases
(R-MMU-1592389)
Assembly of collagen fibrils and other multimeric structures
(R-MMU-2022090)
Axon guidance
(R-MMU-422475)
Collagen degradation
(R-MMU-1442490)
Collagen formation
(R-MMU-1474290)
Degradation of the extracellular matrix
(R-MMU-1474228)
Developmental biology
(R-MMU-1266738)
Eph-ephrin mediated repulsion of cells
(R-MMU-3928665)
Eph-ephrin signaling
(R-MMU-2682334)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Nervous system development
(R-MMU-9675108)
Neutrophil degranulation
(R-MMU-6798695)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by scf-kit
(R-MMU-1433557)
Signal transduction
(R-MMU-162582)
Apoptotic process
(GO:0006915)
Cell migration
(GO:0016477)
Cellular response to cadmium ion
(GO:0071276)
Cellular response to cell-matrix adhesion
(GO:0071460)
Cellular response to reactive oxygen species
(GO:0034614)
Cellular response to uv-a
(GO:0071492)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen catabolic process
(GO:0030574)
Embryo implantation
(GO:0007566)
Endopeptidase activity
(GO:0004175)
Extracellular matrix
(GO:0031012)
Extracellular matrix organization
(GO:0030198)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibronectin binding
(GO:0001968)
Heart development
(GO:0007507)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Macrophage chemotaxis
(GO:0048246)
Metal ion binding
(GO:0046872)
Metalloendopeptidase activity
(GO:0004222)
Metallopeptidase activity
(GO:0008237)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cation channel activity
(GO:2001258)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
(GO:2001268)
Negative regulation of epithelial cell differentiation involved in kidney development
(GO:2000697)
Negative regulation of fibroblast proliferation
(GO:0048147)
Negative regulation of intrinsic apoptotic signaling pathway
(GO:2001243)
Peptidase activity
(GO:0008233)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna binding
(GO:0043388)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of keratinocyte migration
(GO:0051549)
Positive regulation of leukocyte migration
(GO:0002687)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor binding
(GO:1900122)
Positive regulation of release of cytochrome c from mitochondria
(GO:0090200)
Positive regulation of synaptic plasticity
(GO:0031915)
Positive regulation of vascular associated smooth muscle cell proliferation
(GO:1904707)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein catabolic process
(GO:0030163)
Proteolysis
(GO:0006508)
Response to amyloid-beta
(GO:1904645)
Response to oxidative stress
(GO:0006979)
Response to xenobiotic stimulus
(GO:0009410)
Serine-type endopeptidase activity
(GO:0004252)
Skeletal system development
(GO:0001501)
Tissue remodeling
(GO:0048771)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Matrix metalloproteinase-9

Genular Protein ID: 3983928588

Symbol: MMP9_MOUSE

Name: Matrix metalloproteinase-9

UniProtKB Accession Codes:

P41245 Q06788 Q80XI8 Q9DC02

Database IDs:

Citations:

PubMed ID: 8382489

Title: Molecular cloning and expression of the mouse 105-kDa gelatinase cDNA.

PubMed ID: 8382489

DOI: 10.1006/bbrc.1993.1110

PubMed ID: 8219207

Title: Cloning and expression of the cDNA encoding mouse neutrophil gelatinase: demonstration of coordinate secondary granule protein gene expression during terminal neutrophil maturation.

PubMed ID: 8219207

PubMed ID: 8243459

Title: Mouse gelatinase B. cDNA cloning, regulation of expression and glycosylation in WEHI-3 macrophages and gene organisation.

PubMed ID: 8243459

DOI: 10.1111/j.1432-1033.1993.tb18359.x

PubMed ID: 8132709

Title: High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development.

PubMed ID: 8132709

DOI: 10.1083/jcb.124.6.1091

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11500442

Title: Production of matrix metalloproteinases in response to mycobacterial infection.

PubMed ID: 11500442

DOI: 10.1128/iai.69.9.5661-5670.2001

PubMed ID: 19893577

Title: The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice.

PubMed ID: 19893577

DOI: 10.1038/embor.2009.233

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23142597

Title: The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has chemotactic activity.

PubMed ID: 23142597

DOI: 10.1016/j.bbrc.2012.10.099

PubMed ID: 32883094

Title: Anti-inflammatory actions of soluble ninjurin-1 ameliorate atherosclerosis.

PubMed ID: 32883094

DOI: 10.1161/circulationaha.120.046907

Sequence Information:

Length: 730
Mass: 80535
Checksum: E16F45C24D4D1024
Sequence:

MSPWQPLLLA LLAFGCSSAA PYQRQPTFVV FPKDLKTSNL TDTQLAEAYL YRYGYTRAAQ 
MMGEKQSLRP ALLMLQKQLS LPQTGELDSQ TLKAIRTPRC GVPDVGRFQT FKGLKWDHHN 
ITYWIQNYSE DLPRDMIDDA FARAFAVWGE VAPLTFTRVY GPEADIVIQF GVAEHGDGYP 
FDGKDGLLAH AFPPGAGVQG DAHFDDDELW SLGKGVVIPT YYGNSNGAPC HFPFTFEGRS 
YSACTTDGRN DGTPWCSTTA DYDKDGKFGF CPSERLYTEH GNGEGKPCVF PFIFEGRSYS 
ACTTKGRSDG YRWCATTANY DQDKLYGFCP TRVDATVVGG NSAGELCVFP FVFLGKQYSS 
CTSDGRRDGR LWCATTSNFD TDKKWGFCPD QGYSLFLVAA HEFGHALGLD HSSVPEALMY 
PLYSYLEGFP LNKDDIDGIQ YLYGRGSKPD PRPPATTTTE PQPTAPPTMC PTIPPTAYPT 
VGPTVGPTGA PSPGPTSSPS PGPTGAPSPG PTAPPTAGSS EASTESLSPA DNPCNVDVFD 
AIAEIQGALH FFKDGWYWKF LNHRGSPLQG PFLTARTWPA LPATLDSAFE DPQTKRVFFF 
SGRQMWVYTG KTVLGPRSLD KLGLGPEVTH VSGLLPRRLG KALLFSKGRV WRFDLKSQKV 
DPQSVIRVDK EFSGVPWNSH DIFQYQDKAY FCHGKFFWRV SFQNEVNKVD HEVNQVDDVG 
YVTYDLLQCP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mmp9

Associated with

Other Information

Molecular cloning and expression of the mouse 105-kDa gelatinase cDNA. PubMed ID: 8382489

Cloning and expression of the cDNA encoding mouse neutrophil gelatinase: demonstration of coordinate secondary granule protein gene expression during terminal neutrophil maturation. PubMed ID: 8219207

Mouse gelatinase B. cDNA cloning, regulation of expression and glycosylation in WEHI-3 macrophages and gene organisation. PubMed ID: 8243459

High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development. PubMed ID: 8132709

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Production of matrix metalloproteinases in response to mycobacterial infection. PubMed ID: 11500442

The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. PubMed ID: 19893577

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has chemotactic activity. PubMed ID: 23142597

Anti-inflammatory actions of soluble ninjurin-1 ameliorate atherosclerosis. PubMed ID: 32883094