Genular: Defining Cellular Identity and Function

Details for: Foxk1

Gene ID: 17425

Symbol: Foxk1

Ensembl ID: ENSMUSG00000056493

Description: forkhead box K1

Associated with

Deubiquitination
(R-MMU-5688426)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Uch proteinases
(R-MMU-5689603)
14-3-3 protein binding
(GO:0071889)
Canonical glycolysis
(GO:0061621)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Intracellular glucose homeostasis
(GO:0001678)
Multicellular organism development
(GO:0007275)
Muscle organ development
(GO:0007517)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of dna-templated transcription
(GO:0045892)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of glucose metabolic process
(GO:0010906)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to starvation
(GO:0042594)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription cis-regulatory region binding
(GO:0000976)

Other Information

Proteins

FOXK1_MOUSE

Genular Protein ID: 166578501

Symbol: FOXK1_MOUSE

Name: N/A

UniProtKB Accession Codes:

P42128 O35939 Q3UHI6 Q3UN67

Database IDs:

Citations:

PubMed ID: 8007964

Title: Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes.

PubMed ID: 8007964

DOI: 10.1128/mcb.14.7.4596-4605.1994

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9271401

Title: Transient expression of a winged-helix protein, MNF-beta, during myogenesis.

PubMed ID: 9271401

DOI: 10.1128/mcb.17.9.5236

PubMed ID: 10620510

Title: The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian Sin3B.

PubMed ID: 10620510

DOI: 10.1042/bj3450335

PubMed ID: 10792059

Title: Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF.

PubMed ID: 10792059

DOI: 10.1073/pnas.100501197

PubMed ID: 12446708

Title: Absence of p21CIP rescues myogenic progenitor cell proliferative and regenerative capacity in Foxk1 null mice.

PubMed ID: 12446708

DOI: 10.1074/jbc.m209200200

PubMed ID: 16376864

Title: Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain.

PubMed ID: 16376864

DOI: 10.1016/j.brainres.2005.11.022

PubMed ID: 17363903

Title: Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells.

PubMed ID: 17363903

DOI: 10.1038/sj.emboj.7601635

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20013826

Title: Fhl2 interacts with Foxk1 and corepresses Foxo4 activity in myogenic progenitors.

PubMed ID: 20013826

DOI: 10.1002/stem.274

PubMed ID: 22956541

Title: Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2.

PubMed ID: 22956541

DOI: 10.1242/jcs.105239

PubMed ID: 22476904

Title: Sin3 interacts with Foxk1 and regulates myogenic progenitors.

PubMed ID: 22476904

DOI: 10.1007/s11010-012-1302-2

PubMed ID: 23714736

Title: The transcription factor Foxk1 is expressed in developing and adult mouse neuroretina.

PubMed ID: 23714736

DOI: 10.1016/j.gep.2013.05.003

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25402684

Title: Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs.

PubMed ID: 25402684

DOI: 10.1038/ncb3062

PubMed ID: 29861159

Title: mTORC1 promotes metabolic reprogramming by the suppression of GSK3-dependent foxk1 phosphorylation.

PubMed ID: 29861159

DOI: 10.1016/j.molcel.2018.04.024

PubMed ID: 30700909

Title: FOXK1 and FOXK2 regulate aerobic glycolysis.

PubMed ID: 30700909

DOI: 10.1038/s41586-019-0900-5

PubMed ID: 12449423

Title: 1H, 15N and 13C resonance assignments for the DNA-binding domain of myocyte nuclear factor (Foxk1).

PubMed ID: 12449423

DOI: 10.1023/a:1020616926152

Sequence Information:

Length: 719
Mass: 74920
Checksum: 0A0D3049B7846328
Sequence:

MAEVGEDSGA RALLALRSAP CSPVLCAAAA AAAFPATTSP PPPAQPPPGP PALPAEPGPG 
PVPSTVATAT TTAPALVAAA AASVRQSPGP ALARLEGREF EFLMRQPSVT IGRNSSQGSV 
DLSMGLSSFI SRRHLQLSFQ EPHFYLRCLG KNGVFVDGAF QRRGAPALQL PQQCTFRFPS 
TAIKIQFTSL YHKEEAPASP LRPLYPQISP LKIHIPEPDL RSLVSPIPSP TGTISVPNSC 
PASPRGAGSS SYRFVQNVTS DLQLAAEFAA KAASEQQADA SGGDSPKDES KPPYSYAQLI 
VQAISSAQDR QLTLSGIYAH ITKHYPYYRT ADKGWQNSIR HNLSLNRYFI KVPRSQEEPG 
KGSFWRIDPA SEAKLVEQAF RKRRQRGVSC FRTPFGPLSS RSAPASPTHP GLMSPRSSGL 
QTPECLSREG SPIPHDPDLG SKLASVPEYR YSQSAPGSPV SAQPVIMAVP PRPSNLVAKP 
VAYMPASIVT SQQPSGHAIH VVQQAPTVTM VRVVTTSANS ANGYILASQG STGTSHDTAG 
TAVLDLGNEA RGLEEKPTIA FATIPAASRV IQTVASQMAP GVPGHTVTIL QPATPVTIGQ 
HHLPVRAVTQ NGKHAVPTNS LTGNAYALSS PLQLLAAQAS SSTPVVITRV CEVGPEEPAA 
AVSVAANAAP TPAASTTTSA SSSGEPEVKR SRVEEPGGTA TTQPTAMAAT GPQGPGTGE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Foxk1

Associated with

Other Information

Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. PubMed ID: 8007964

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Transient expression of a winged-helix protein, MNF-beta, during myogenesis. PubMed ID: 9271401

The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian Sin3B. PubMed ID: 10620510

Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. PubMed ID: 10792059

Absence of p21CIP rescues myogenic progenitor cell proliferative and regenerative capacity in Foxk1 null mice. PubMed ID: 12446708

Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain. PubMed ID: 16376864

Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells. PubMed ID: 17363903

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Fhl2 interacts with Foxk1 and corepresses Foxo4 activity in myogenic progenitors. PubMed ID: 20013826

Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2. PubMed ID: 22956541

Sin3 interacts with Foxk1 and regulates myogenic progenitors. PubMed ID: 22476904

The transcription factor Foxk1 is expressed in developing and adult mouse neuroretina. PubMed ID: 23714736

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs. PubMed ID: 25402684

mTORC1 promotes metabolic reprogramming by the suppression of GSK3-dependent foxk1 phosphorylation. PubMed ID: 29861159

FOXK1 and FOXK2 regulate aerobic glycolysis. PubMed ID: 30700909

1H, 15N and 13C resonance assignments for the DNA-binding domain of myocyte nuclear factor (Foxk1). PubMed ID: 12449423