Genular: Defining Cellular Identity and Function

Details for: Grap2

Gene ID: 17444

Symbol: Grap2

Ensembl ID: ENSMUSG00000042351

Description: GRB2-related adaptor protein 2

Associated with

Adaptive immune system
(R-MMU-1280218)
Cd28 co-stimulation
(R-MMU-389356)
Costimulation by the cd28 family
(R-MMU-388841)
Cytokine signaling in immune system
(R-MMU-1280215)
Dap12 interactions
(R-MMU-2172127)
Dap12 signaling
(R-MMU-2424491)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated ca+2 mobilization
(R-MMU-2871809)
Fceri mediated mapk activation
(R-MMU-2871796)
Flt3 signaling
(R-MMU-9607240)
Generation of second messenger molecules
(R-MMU-202433)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by scf-kit
(R-MMU-1433557)
Tcr signaling
(R-MMU-202403)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endosome
(GO:0005768)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphotyrosine residue binding
(GO:0001784)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of mapk cascade
(GO:0043408)
Signal transduction
(GO:0007165)

Other Information

Proteins

GRB2-related adaptor protein 2

Genular Protein ID: 2808041695

Symbol: GRAP2_MOUSE

Name: GRB2-related adaptor protein 2

UniProtKB Accession Codes:

O89100

Database IDs:

Citations:

PubMed ID: 9857184

Title: Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development.

PubMed ID: 9857184

DOI: 10.1093/emboj/17.24.7273

PubMed ID: 9872323

Title: Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.

PubMed ID: 9872323

DOI: 10.1038/sj.onc.1202337

PubMed ID: 10209041

Title: GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation.

PubMed ID: 10209041

DOI: 10.1084/jem.189.8.1243

PubMed ID: 10820259

Title: GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28.

PubMed ID: 10820259

DOI: 10.4049/jimmunol.164.11.5805

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14610044

Title: LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.

PubMed ID: 14610044

DOI: 10.1084/jem.20030232

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 322
Mass: 36810
Checksum: 736311D0640CD3D0
Sequence:

MEATAKFDFM ASGEDELSFR TGDILKILSN QEEWLKAELG SQEGYVPKNF IDIEFPEWFH 
EGLSRHQAEN LLMGKDIGFF IIRASQSSPG DFSISVRHED DVQHFKVMRD TKGNYFLWTE 
KFPSLNKLVD YYRTTSISKQ KQVFLRDGTQ DQGHRGNSLD RRSQGGPHPS GTVGEEIRPS 
VNRKLSDHLP LGPQQFHPHQ QPSPQFTPGP QPPQQQRYLQ HFHQDRRGGS LDINDGHCGL 
GSEVNATLMH RRHTDPVQLQ AAGRVRWARA LYDFEALEED ELGFRSGEVV EVLDSSNPSW 
WTGRLHNKLG LFPANYVAPM MR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Grap2

Associated with

Other Information

Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development. PubMed ID: 9857184

Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc. PubMed ID: 9872323

GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation. PubMed ID: 10209041

GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28. PubMed ID: 10820259

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation. PubMed ID: 14610044

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079