Genular: Defining Cellular Identity and Function

Details for: Gbp4

Gene ID: 17472

Symbol: Gbp4

Ensembl ID: ENSMUSG00000079363

Description: guanylate binding protein 4

Associated with

Cellular response to type ii interferon
(GO:0071346)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Defense response to gram-positive bacterium
(GO:0050830)
Defense response to protozoan
(GO:0042832)
Golgi apparatus
(GO:0005794)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Membrane
(GO:0016020)
Negative regulation of interferon-alpha production
(GO:0032687)
Negative regulation of protein import into nucleus
(GO:0042308)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of defense response to virus
(GO:0050688)
Ubiquitin-protein transferase inhibitor activity
(GO:0055105)

Other Information

Proteins

Guanylate-binding protein 4

Genular Protein ID: 3447777041

Symbol: GBP4_MOUSE

Name: Guanylate-binding protein 4

UniProtKB Accession Codes:

A4UUI3 A0A0G2JDT5 A0A0G2JEJ5 A0A0G2JGT4 B9EJ74 Q61594

Database IDs:

Citations:

PubMed ID: 18025219

Title: Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.

PubMed ID: 18025219

DOI: 10.4049/jimmunol.179.11.7729

PubMed ID: 1753106

Title: Identification and characterization of a new gene family induced during macrophage activation.

PubMed ID: 1753106

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22095711

Title: Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7.

PubMed ID: 22095711

DOI: 10.4049/jimmunol.1003691

Sequence Information:

Length: 631
Mass: 72042
Checksum: F726003F758997D6
Sequence:

MTQPQMAPIC LVENHNEQLS VNQEAIEILD KISQPVVVVA IVGWSHTGKS YLMNCLAGQN 
HVSGTLPTSQ RFPSGLHRAV SDQGHLDVVH APPHQARALV LLDTEGLGDV EKGDPKNDLW 
IFALSVLLSS TFVYNSMNTI NHQALEQLHY VTELTELIRA KSSPNPHGIK NSTEFVSFFP 
DFVWTVRDFM LELKLNGEDI TSDEYLENAL KLIPGNNPRI QASNSARECI RRFFPNRKCF 
VFEWPTHDIE LIKQLETISE DQLDPTFKES AMAFASYIFT YAKIKTLREG IKVTGNGLGT 
LVTTYVDAIN SGAVPCLDDA VTTLAQRENS VAVQKAASHY SEQMAQRLSL PTDTIQELLD 
VHAACEKEAM AVFMEHSFKD ENQQFLKKLV ELLREKNGLF LLKNEEASDK YCQEELDRLS 
KDLMDNISTF SVPGGHRLYM DMREKIEHDY WQVPRKGVKA SEVFQNFLQS QAIIESSILQ 
ADTALTAGQK AIAEKHTKKE AAEKEQDLLR QKQKEHQEYM EAQEKRNKEN LEQLRRKLEQ 
EREQLIKDHN MMLEKLTKEQ KTFREEGYKT QAEELRREIH QLGHNIKEMK QNGDSLVESI 
LRSWFSFISP PSESEKAISS VLSLLRKKDR L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gbp4

Associated with

Other Information

Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. PubMed ID: 18025219

Identification and characterization of a new gene family induced during macrophage activation. PubMed ID: 1753106

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303