Genular: Defining Cellular Identity and Function

Details for: Mre11a

Gene ID: 17535

Symbol: Mre11a

Ensembl ID: ENSMUSG00000031928

Description: MRE11A homolog A, double strand break repair nuclease

Associated with

Cell cycle
(R-MMU-1640170)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Cytosolic sensors of pathogen-associated dna
(R-MMU-1834949)
Dna damage/telomere stress induced senescence
(R-MMU-2559586)
Dna double-strand break repair
(R-MMU-5693532)
Dna double strand break response
(R-MMU-5693606)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdr through homologous recombination (hrr)
(R-MMU-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Hdr through mmej (alt-nhej)
(R-MMU-5685939)
Hdr through single strand annealing (ssa)
(R-MMU-5685938)
Homologous dna pairing and strand exchange
(R-MMU-5693579)
Homology directed repair
(R-MMU-5693538)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Nonhomologous end-joining (nhej)
(R-MMU-5693571)
Presynaptic phase of homologous dna pairing and strand exchange
(R-MMU-5693616)
Processing of dna double-strand break ends
(R-MMU-5693607)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-MMU-5693565)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Resolution of d-loop structures
(R-MMU-5693537)
Resolution of d-loop structures through holliday junction intermediates
(R-MMU-5693568)
Rna polymerase ii transcription
(R-MMU-73857)
Sensing of dna double strand breaks
(R-MMU-5693548)
Transcriptional regulation by tp53
(R-MMU-3700989)
3'-5'-dna exonuclease activity
(GO:0008296)
3'-5' exonuclease activity
(GO:0008408)
5'-3' exonuclease activity
(GO:0008409)
Brca1-c complex
(GO:0070533)
Cell population proliferation
(GO:0008283)
Chromatin
(GO:0000785)
Chromosomal region
(GO:0098687)
Chromosome
(GO:0005694)
Chromosome, telomeric region
(GO:0000781)
Chromosome organization
(GO:0051276)
Condensed nuclear chromosome
(GO:0000794)
Cytoplasm
(GO:0005737)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna double-strand break processing
(GO:0000729)
Dna duplex unwinding
(GO:0032508)
Dna endonuclease activity
(GO:0004520)
Dna helicase activity
(GO:0003678)
Dna repair
(GO:0006281)
Dna strand resection involved in replication fork processing
(GO:0110025)
Double-strand break repair
(GO:0006302)
Double-strand break repair via homologous recombination
(GO:0000724)
Double-strand break repair via nonhomologous end joining
(GO:0006303)
Endonuclease activity
(GO:0004519)
Exonuclease activity
(GO:0004527)
Homologous chromosome pairing at meiosis
(GO:0007129)
Homologous recombination
(GO:0035825)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Manganese ion binding
(GO:0030145)
Meiotic cell cycle
(GO:0051321)
Meiotic dna double-strand break formation
(GO:0042138)
Mitochondrial double-strand break repair via homologous recombination
(GO:0097552)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Mitotic g2/m transition checkpoint
(GO:0044818)
Mitotic intra-s dna damage checkpoint signaling
(GO:0031573)
Mre11 complex
(GO:0030870)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of viral entry into host cell
(GO:0046597)
Nuclease activity
(GO:0004518)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Pml body
(GO:0016605)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of protein autophosphorylation
(GO:0031954)
Positive regulation of telomere maintenance
(GO:0032206)
Protein binding
(GO:0005515)
Replication fork
(GO:0005657)
Single-stranded dna endodeoxyribonuclease activity
(GO:0000014)
Sister chromatid cohesion
(GO:0007062)
Site of double-strand break
(GO:0035861)
Telomere maintenance
(GO:0000723)
Telomeric 3' overhang formation
(GO:0031860)

Other Information

Proteins

Genular Protein ID: 4228077298

Symbol: MRE11_MOUSE

Name: Double-strand break repair protein MRE11

UniProtKB Accession Codes:

Q61216 Q62430

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 30017584

Title: MRI is a DNA damage response adaptor during classical non-homologous end joining.

PubMed ID: 30017584

DOI: 10.1016/j.molcel.2018.06.018

Sequence Information:

Length: 706
Mass: 80223
Checksum: 0F12F51902FC179A
Sequence:

MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD 
LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEVISDQSVN FGFSKFPWVN YQDGNLNISI 
PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG 
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGNTNFIP EQFLDDFIDL 
VIWGHEHECK IGPIKNEQQL FYVSQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMQKLP 
LRTVRRFFIE DVVLANHPNL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPGK 
PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGMLITK 
PASEGATLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE 
KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSETSTSA 
FSAEDLSFDT SEQTANDSDD SLSAVPSRGR GRGRGRRGAR GQSSAPRGGS QRGRDTGLEI 
TTRGRSSKAT SSTSRNMSII DAFRSTRQQP SRNVAPKNYS ETIEVDDSDE DDIFPTNSRA 
DQRWSGTTSS KRMSQSQTAK GVDFESDEDD DDDPFMSSSC PRRNRR

Genular Protein ID: 995530459

Symbol: Q3TU24_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TU24

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 237
Mass: 26765
Checksum: C03B182848D2B01F
Sequence:

AIEELVKYQL EKTQRFLKER HIDALEDKID EEVRRFRESR QRNTNEEDDE VREAMSRARA 
LRSQSETSTS AFSAEDLSFD TSEQTANDSD DSLSAVPSRG RGRGRGRRGA RGQSSAPRGG 
SQRGRDTGLE ITTRGRSSKA TSSTSRNMSI IDAFRSTRQQ PSRNVAPKNY SETIEVDDSD 
EDDIFPTNSR ADQRWSGTTS SKRMSQSQTA KGVDFESDED DDDDPFMSSS CPRRNRR

Genular Protein ID: 2059476194

Symbol: Q8BRV3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BRV3

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 513
Mass: 58975
Checksum: 9A7CFE63D0FF5161
Sequence:

MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD 
LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEVISDQSVN FGFSKFPWVN YQDGNLNISI 
PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG 
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGNTNFIP EQFLDDFIDL 
VIWGHEHECK IGPIKNEQQL FYVSQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMQKLP 
LRTVRRFFIE DVVLANHPNL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPGK 
PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGMLITK 
PASEGATLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE 
KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mre11a

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

MRI is a DNA damage response adaptor during classical non-homologous end joining. PubMed ID: 30017584

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Database document:

PubMed ID: 15489334

PubMed ID: 17242355

PubMed ID: 21183079

PubMed ID: 30017584

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073