Details for: ACAN

Gene ID: 176

Symbol: ACAN

Ensembl ID: ENSG00000157766

Description: aggrecan

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 33.3665
    Cell Significance Index: -5.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.5012
    Cell Significance Index: -5.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3818
    Cell Significance Index: 33.4700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.6203
    Cell Significance Index: 5.6300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5093
    Cell Significance Index: 7.8800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5024
    Cell Significance Index: 7.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4687
    Cell Significance Index: 12.5600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4250
    Cell Significance Index: 3.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3803
    Cell Significance Index: 8.3300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.2572
    Cell Significance Index: 1.5100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2430
    Cell Significance Index: 3.0700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2130
    Cell Significance Index: 1.8100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1690
    Cell Significance Index: 1.0500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0990
    Cell Significance Index: 2.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0731
    Cell Significance Index: 1.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0372
    Cell Significance Index: 0.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0224
    Cell Significance Index: 15.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0065
    Cell Significance Index: 0.1100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0064
    Cell Significance Index: 0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0042
    Cell Significance Index: 0.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0033
    Cell Significance Index: -0.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0048
    Cell Significance Index: -6.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0064
    Cell Significance Index: -2.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0065
    Cell Significance Index: -4.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0077
    Cell Significance Index: -5.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0091
    Cell Significance Index: -0.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0096
    Cell Significance Index: -5.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0104
    Cell Significance Index: -5.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0106
    Cell Significance Index: -4.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0116
    Cell Significance Index: -3.3500
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0122
    Cell Significance Index: -0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0162
    Cell Significance Index: -3.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0223
    Cell Significance Index: -4.0200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0237
    Cell Significance Index: -0.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0255
    Cell Significance Index: -3.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0286
    Cell Significance Index: -6.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0290
    Cell Significance Index: -3.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0295
    Cell Significance Index: -5.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0356
    Cell Significance Index: -4.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0356
    Cell Significance Index: -4.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0374
    Cell Significance Index: -3.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0377
    Cell Significance Index: -0.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0383
    Cell Significance Index: -5.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0485
    Cell Significance Index: -5.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0516
    Cell Significance Index: -5.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0537
    Cell Significance Index: -1.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0562
    Cell Significance Index: -3.5400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0584
    Cell Significance Index: -0.8300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0594
    Cell Significance Index: -0.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0627
    Cell Significance Index: -2.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0657
    Cell Significance Index: -4.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0665
    Cell Significance Index: -4.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0693
    Cell Significance Index: -3.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0697
    Cell Significance Index: -5.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0727
    Cell Significance Index: -3.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0728
    Cell Significance Index: -3.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0763
    Cell Significance Index: -4.6900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0776
    Cell Significance Index: -1.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0781
    Cell Significance Index: -5.0400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0791
    Cell Significance Index: -0.8600
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.0821
    Cell Significance Index: -0.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0830
    Cell Significance Index: -3.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0875
    Cell Significance Index: -4.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0880
    Cell Significance Index: -4.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0973
    Cell Significance Index: -3.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1004
    Cell Significance Index: -1.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1072
    Cell Significance Index: -5.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1082
    Cell Significance Index: -2.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1094
    Cell Significance Index: -4.8400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1133
    Cell Significance Index: -1.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1183
    Cell Significance Index: -4.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1265
    Cell Significance Index: -4.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1324
    Cell Significance Index: -4.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1390
    Cell Significance Index: -4.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1473
    Cell Significance Index: -4.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1521
    Cell Significance Index: -4.4800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1632
    Cell Significance Index: -1.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1674
    Cell Significance Index: -4.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1684
    Cell Significance Index: -4.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1696
    Cell Significance Index: -3.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1700
    Cell Significance Index: -4.8500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1746
    Cell Significance Index: -3.6500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1753
    Cell Significance Index: -1.6900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1761
    Cell Significance Index: -5.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1773
    Cell Significance Index: -3.8300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1781
    Cell Significance Index: -1.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1816
    Cell Significance Index: -6.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1849
    Cell Significance Index: -2.1000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1874
    Cell Significance Index: -1.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1888
    Cell Significance Index: -4.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1903
    Cell Significance Index: -3.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1953
    Cell Significance Index: -4.9900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1962
    Cell Significance Index: -5.0000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1971
    Cell Significance Index: -2.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1997
    Cell Significance Index: -4.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** Aggrecan is a large, negatively charged proteoglycan composed of a core protein (PGCA_HUMAN) and a long chain of glycosaminoglycans (GAGs), including hyaluronic acid and keratan sulfate. 2. **Expression:** Aggrecan is widely expressed in various tissues, including cartilage, bone, and the central nervous system. 3. **Function:** Aggrecan regulates cell adhesion, migration, and differentiation by binding to hyaluronic acid and keratan sulfate, thereby influencing ECM organization and tissue function. **Pathways and Functions:** 1. **ECM organization:** Aggrecan plays a crucial role in maintaining the structure and function of the ECM by regulating cell adhesion, migration, and differentiation. 2. **Immune regulation:** Aggrecan has been implicated in immune regulation, particularly in the context of autoimmune diseases and cancer. It modulates the activity of immune cells, such as T cells and macrophages, and regulates the production of pro-inflammatory cytokines. 3. **Glycosylation:** Aggrecan is involved in glycosylation processes, including the synthesis and degradation of glycosaminoglycans. 4. **Cell signaling:** Aggrecan interacts with various signaling molecules, including growth factors and cytokines, to regulate cell behavior and tissue function. **Clinical Significance:** 1. **Autoimmune diseases:** Aggrecan has been implicated in various autoimmune diseases, including rheumatoid arthritis, osteoarthritis, and multiple sclerosis. Dysregulation of aggrecan expression and function contributes to disease pathogenesis. 2. **Cancer:** Aggrecan has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer. It promotes tumor growth, metastasis, and immune evasion. 3. **Neurological disorders:** Aggrecan has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. It regulates synaptic plasticity and neuronal survival. 4. **Wound healing:** Aggrecan plays a crucial role in wound healing, regulating the production of growth factors and cytokines that promote tissue repair. In conclusion, aggrecan (ACAN) is a multifunctional proteoglycan that plays a critical role in maintaining tissue structure and function, regulating immune responses, and influencing disease pathogenesis. Further research is needed to fully elucidate the mechanisms underlying aggrecan's roles in human disease and to develop novel therapeutic strategies targeting this protein.

Genular Protein ID: 3653008861

Symbol: PGCA_HUMAN

Name: Aggrecan core protein

UniProtKB Accession Codes:

P16112 B9EK55 E7ENV9 E7EX88 H0YM81 Q13650 Q9UCD3 Q9UCP4 Q9UCP5 Q9UDE0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 6 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 10 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 7 RefSeq 3 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1985970

Title: Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.

PubMed ID: 1985970

DOI: 10.1016/s0021-9258(17)35257-2

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7574678

Title: Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid.

PubMed ID: 7574678

DOI: 10.1006/abbi.1995.1431

PubMed ID: 1569188

Title: The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.

PubMed ID: 1569188

DOI: 10.1172/jci115742

PubMed ID: 7524681

Title: Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes.

PubMed ID: 7524681

DOI: 10.1016/0167-4781(94)90220-8

PubMed ID: 8216415

Title: The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis.

PubMed ID: 8216415

DOI: 10.1002/art.1780360906

PubMed ID: 7827755

Title: Length variation in the keratan sulfate domain of mammalian aggrecan.

PubMed ID: 7827755

DOI: 10.1016/0945-053x(94)90198-8

PubMed ID: 8611178

Title: Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage.

PubMed ID: 8611178

DOI: 10.1042/bj3130933

PubMed ID: 2789216

Title: A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain.

PubMed ID: 2789216

DOI: 10.1016/s0021-9258(18)71537-8

PubMed ID: 16080123

Title: A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis.

PubMed ID: 16080123

DOI: 10.1086/444401

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17588949

Title: Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan.

PubMed ID: 17588949

DOI: 10.1074/jbc.m611390200

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

PubMed ID: 19110214

Title: A recessive skeletal dysplasia, SEMD aggrecan type, results from a missense mutation affecting the C-type lectin domain of aggrecan.

PubMed ID: 19110214

DOI: 10.1016/j.ajhg.2008.12.001

PubMed ID: 20137779

Title: A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans.

PubMed ID: 20137779

DOI: 10.1016/j.ajhg.2009.12.018

Sequence Information:

  • Length: 2530
  • Mass: 261329
  • Checksum: 3C809F6DE829956B
  • Sequence:
    • MTTLLWVFVT LRVITAAVTV ETSDHDNSLS VSIPQPSPLR VLLGTSLTIP CYFIDPMHPV 
TTAPSTAPLA PRIKWSRVSK EKEVVLLVAT EGRVRVNSAY QDKVSLPNYP AIPSDATLEV 
QSLRSNDSGV YRCEVMHGIE DSEATLEVVV KGIVFHYRAI STRYTLDFDR AQRACLQNSA 
IIATPEQLQA AYEDGFHQCD AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE 
TYDVYCFAEE MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QAGMDMCSAG 
WLADRSVRYP ISKARPNCGG NLLGVRTVYV HANQTGYPDP SSRYDAICYT GEDFVDIPEN 
FFGVGGEEDI TVQTVTWPDM ELPLPRNITE GEARGSVILT VKPIFEVSPS PLEPEEPFTF 
APEIGATAFA EVENETGEAT RPWGFPTPGL GPATAFTSED LVVQVTAVPG QPHLPGGVVF 
HYRPGPTRYS LTFEEAQQAC LRTGAVIASP EQLQAAYEAG YEQCDAGWLR DQTVRYPIVS 
PRTPCVGDKD SSPGVRTYGV RPSTETYDVY CFVDRLEGEV FFATRLEQFT FQEALEFCES 
HNATLATTGQ LYAAWSRGLD KCYAGWLADG SLRYPIVTPR PACGGDKPGV RTVYLYPNQT 
GLPDPLSRHH AFCFRGISAV PSPGEEEGGT PTSPSGVEEW IVTQVVPGVA AVPVEEETTA 
VPSGETTAIL EFTTEPENQT EWEPAYTPVG TSPLPGILPT WPPTGAATEE STEGPSATEV 
PSASEEPSPS EVPFPSEEPS PSEEPFPSVR PFPSVELFPS EEPFPSKEPS PSEEPSASEE 
PYTPSPPVPS WTELPSSGEE SGAPDVSGDF TGSGDVSGHL DFSGQLSGDR ASGLPSGDLD 
SSGLTSTVGS GLPVESGLPS GDEERIEWPS TPTVGELPSG AEILEGSASG VGDLSGLPSG 
EVLETSASGV GDLSGLPSGE VLETTAPGVE DISGLPSGEV LETTAPGVED ISGLPSGEVL 
ETTAPGVEDI SGLPSGEVLE TTAPGVEDIS GLPSGEVLET TAPGVEDISG LPSGEVLETT 
APGVEDISGL PSGEVLETAA PGVEDISGLP SGEVLETAAP GVEDISGLPS GEVLETAAPG 
VEDISGLPSG EVLETAAPGV EDISGLPSGE VLETAAPGVE DISGLPSGEV LETAAPGVED 
ISGLPSGEVL ETAAPGVEDI SGLPSGEVLE TAAPGVEDIS GLPSGEVLET AAPGVEDISG 
LPSGEVLETA APGVEDISGL PSGEVLETAA PGVEDISGLP SGEVLETAAP GVEDISGLPS 
GEVLETAAPG VEDISGLPSG EVLETAAPGV EDISGLPSGE VLETAAPGVE DISGLPSGEV 
LETAAPGVED ISGLPSGEVL ETTAPGVEEI SGLPSGEVLE TTAPGVDEIS GLPSGEVLET 
TAPGVEEISG LPSGEVLETS TSAVGDLSGL PSGGEVLEIS VSGVEDISGL PSGEVVETSA 
SGIEDVSELP SGEGLETSAS GVEDLSRLPS GEEVLEISAS GFGDLSGLPS GGEGLETSAS 
EVGTDLSGLP SGREGLETSA SGAEDLSGLP SGKEDLVGSA SGDLDLGKLP SGTLGSGQAP 
ETSGLPSGFS GEYSGVDLGS GPPSGLPDFS GLPSGFPTVS LVDSTLVEVV TASTASELEG 
RGTIGISGAG EISGLPSSEL DISGRASGLP SGTELSGQAS GSPDVSGEIP GLFGVSGQPS 
GFPDTSGETS GVTELSGLSS GQPGISGEAS GVLYGTSQPF GITDLSGETS GVPDLSGQPS 
GLPGFSGATS GVPDLVSGTT SGSGESSGIT FVDTSLVEVA PTTFKEEEGL GSVELSGLPS 
GEADLSGKSG MVDVSGQFSG TVDSSGFTSQ TPEFSGLPSG IAEVSGESSR AEIGSSLPSG 
AYYGSGTPSS FPTVSLVDRT LVESVTQAPT AQEAGEGPSG ILELSGAHSG APDMSGEHSG 
FLDLSGLQSG LIEPSGEPPG TPYFSGDFAS TTNVSGESSV AMGTSGEASG LPEVTLITSE 
FVEGVTEPTI SQELGQRPPV THTPQLFESS GKVSTAGDIS GATPVLPGSG VEVSSVPESS 
SETSAYPEAG FGASAAPEAS REDSGSPDLS ETTSAFHEAN LERSSGLGVS GSTLTFQEGE 
ASAAPEVSGE STTTSDVGTE APGLPSATPT ASGDRTEISG DLSGHTSQLG VVISTSIPES 
EWTQQTQRPA ETHLEIESSS LLYSGEETHT VETATSPTDA SIPASPEWKR ESESTAAAPA 
RSCAEEPCGA GTCKETEGHV ICLCPPGYTG EHCNIDQEVC EEGWNKYQGH CYRHFPDRET 
WVDAERRCRE QQSHLSSIVT PEEQEFVNNN AQDYQWIGLN DRTIEGDFRW SDGHPMQFEN 
WRPNQPDNFF AAGEDCVVMI WHEKGEWNDV PCNYHLPFTC KKGTVACGEP PVVEHARTFG 
QKKDRYEINS LVRYQCTEGF VQRHMPTIRC QPSGHWEEPQ ITCTDPTTYK RRLQKRSSRH 
PRRSRPSTAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.